46 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DLX2	Distal-less homeobox 2. (328 aa)
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	NR1D1	Nuclear receptor subfamily 1, group D, member 1. (614 aa)
	TMEM98	Transmembrane protein 98. (226 aa)
	NF1	Neurofibromin 1. (2839 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
	RB1	RB transcriptional corepressor 1. (928 aa)
	RNF10	Ring finger protein 10. (816 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
	NKX6-2	NKX6-2 isoform 1. (276 aa)
	PITX3	Homeobox protein. (302 aa)
	GPR37L1	G protein-coupled receptor 37 like 1. (481 aa)
	SKI	V-ski sarcoma viral oncogene homolog (Avian). (736 aa)
	KDM4A	Lysine (K)-specific demethylase 4A. (1064 aa)
	NR2E1-2	Nuclear receptor subfamily 2 group E member 1. (385 aa)
	SOX11	Transcription factor SOX. (441 aa)
	LIN28A	LIN28A isoform 1. (209 aa)
	DUSP10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (488 aa)
	ENSPTRP00000085820	annotation not available (199 aa)
	CDKN2B	Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4). (138 aa)
	ASCL2	Achaete-scute family bHLH transcription factor 2. (193 aa)
	HES5-2	Hes family bHLH transcription factor 5. (165 aa)
	ENSPTRP00000077268	annotation not available (202 aa)
	LDLR	LDLR isoform 7. (917 aa)
	DAAM2	Dishevelled associated activator of morphogenesis 2. (1077 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (422 aa)
	NF2	Neurofibromin 2 (Merlin). (595 aa)
	ID4	Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein. (161 aa)
	ENSPTRP00000069560	annotation not available (214 aa)
	MBD1	Methyl-CpG binding domain protein 1. (630 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	ATOH1	Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). (356 aa)
	DAB1	DAB adaptor protein 1. (588 aa)
	LINGO1	Leucine rich repeat and Ig domain containing 1. (620 aa)
	ABCC8	ABCC8 isoform 2. (1582 aa)
	DICER1	Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily. (1922 aa)
	CTNNB1	Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
	SOX10	SRY-box transcription factor 10. (466 aa)
	TSPO	Translocator protein. (169 aa)
	HES5	Hes family bHLH transcription factor 5. (165 aa)
	CERS2	LAG1 homolog, ceramide synthase 2. (380 aa)
	DLX1	Distal-less homeobox 1. (255 aa)
	NOTCH1	NOTCH1 isoform 1. (2555 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	NKX6-1	NKX6-1 isoform 2. (367 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCC8	NKX6-1	ENSPTRP00000048225	ENSPTRP00000027895	ABCC8 isoform 2.	NKX6-1 isoform 2.	0.463
ASCL2	ATOH1	ENSPTRP00000080760	ENSPTRP00000053413	Achaete-scute family bHLH transcription factor 2.	Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).	0.427
ASCL2	CTNNB1	ENSPTRP00000080760	ENSPTRP00000044466	Achaete-scute family bHLH transcription factor 2.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.429
ASCL2	HES1	ENSPTRP00000080760	ENSPTRP00000064171	Achaete-scute family bHLH transcription factor 2.	Hes family bHLH transcription factor 1.	0.448
ASCL2	KDM4A	ENSPTRP00000080760	ENSPTRP00000001106	Achaete-scute family bHLH transcription factor 2.	Lysine (K)-specific demethylase 4A.	0.467
ATOH1	ASCL2	ENSPTRP00000053413	ENSPTRP00000080760	Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).	Achaete-scute family bHLH transcription factor 2.	0.427
ATOH1	HES1	ENSPTRP00000053413	ENSPTRP00000064171	Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).	Hes family bHLH transcription factor 1.	0.401
ATOH1	HES5	ENSPTRP00000053413	ENSPTRP00000040760	Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).	Hes family bHLH transcription factor 5.	0.468
ATOH1	HES5-2	ENSPTRP00000053413	ENSPTRP00000080637	Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).	Hes family bHLH transcription factor 5.	0.468
ATOH1	NOTCH1	ENSPTRP00000053413	ENSPTRP00000036924	Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).	NOTCH1 isoform 1.	0.472
CDKN2B	CTNNB1	ENSPTRP00000082876	ENSPTRP00000044466	Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4).	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.404
CDKN2B	HES1	ENSPTRP00000082876	ENSPTRP00000064171	Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4).	Hes family bHLH transcription factor 1.	0.441
CDKN2B	NF1	ENSPTRP00000082876	ENSPTRP00000015312	Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4).	Neurofibromin 1.	0.428
CDKN2B	RB1	ENSPTRP00000082876	ENSPTRP00000009974	Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4).	RB transcriptional corepressor 1.	0.423
CDKN2B	TP53	ENSPTRP00000082876	ENSPTRP00000014836	Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4).	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.833
CTNNB1	ASCL2	ENSPTRP00000044466	ENSPTRP00000080760	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Achaete-scute family bHLH transcription factor 2.	0.429
CTNNB1	CDKN2B	ENSPTRP00000044466	ENSPTRP00000082876	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4).	0.404
CTNNB1	DAAM2	ENSPTRP00000044466	ENSPTRP00000074068	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Dishevelled associated activator of morphogenesis 2.	0.434
CTNNB1	DICER1	ENSPTRP00000044466	ENSPTRP00000046628	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily.	0.462
CTNNB1	NF1	ENSPTRP00000044466	ENSPTRP00000015312	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Neurofibromin 1.	0.418