STRINGSTRING
HES1 HES1 PHACTR4 PHACTR4 ENSPTRP00000064416 ENSPTRP00000064416 FOXC1 FOXC1 SEMA3E SEMA3E ENSPTRP00000066737 ENSPTRP00000066737 SEMA6A SEMA6A SMO-2 SMO-2 TCOF1 TCOF1 SEMA4A SEMA4A LOC459002 LOC459002 EDN3 EDN3 ACVR1 ACVR1 SEMA4G SEMA4G FAM172A FAM172A CDC42 CDC42 ENSPTRP00000078649 ENSPTRP00000078649 SEMA3F SEMA3F ANXA6 ANXA6 CITED2 CITED2 SEMA6D SEMA6D FBXL17 FBXL17 ENSPTRP00000083815 ENSPTRP00000083815 LOC104003681 LOC104003681 SEMA3B SEMA3B ENSPTRP00000087014 ENSPTRP00000087014 WNT8A WNT8A LAMA5 LAMA5 EFNB1 EFNB1 MEF2C MEF2C SOX11 SOX11 ENSPTRP00000091667 ENSPTRP00000091667 NRG1 NRG1 OVOL2 OVOL2 CDH2 CDH2 ENSPTRP00000074987 ENSPTRP00000074987 SHH SHH PEF1 PEF1 SEMA6C SEMA6C KLHL12 KLHL12 NRP1 NRP1 RET RET BMPR1A BMPR1A CYP26C1 CYP26C1 FGF19 FGF19 FOLR1 FOLR1 LRP6 LRP6 ALX1 ALX1 KITLG KITLG CORO1C CORO1C EDNRB EDNRB HIF1A HIF1A GSC GSC ALDH1A2 ALDH1A2 SEMA7A SEMA7A SEMA4B SEMA4B SOX8 SOX8 SOX9 SOX9 SMAD4 SMAD4 SEMA6B SEMA6B NRTN NRTN RPS7 RPS7 SEMA4C SEMA4C FRZB FRZB NRP2 NRP2 WNT10A WNT10A HTR2B HTR2B GBX2 GBX2 JAG1 JAG1 TBX1 TBX1 MAPK1 MAPK1 SEMA3G SEMA3G KBTBD8 KBTBD8 SEMA5B SEMA5B PHOX2B PHOX2B PITX2 PITX2 EDNRA EDNRA SEMA5A SEMA5A ISL1 ISL1 EDN1 EDN1 SEMA3C SEMA3C SEMA3A SEMA3A SEMA3D SEMA3D SMO SMO SNAI2 SNAI2 RDH10 RDH10 EXT1 EXT1 OTUD5 OTUD5 SOX10 SOX10 FN1 FN1 NOLC1 NOLC1 SEMA4F SEMA4F TWIST1 TWIST1 GDNF GDNF SEMA4D SEMA4D HAND2 HAND2 SFRP1 SFRP1 FOXC2 FOXC2 MAPK3 MAPK3 ENSPTRP00000055426 ENSPTRP00000055426 RADIL RADIL TAPT1 TAPT1 ERBB4 ERBB4 LOC735645 LOC735645 ENSPTRP00000063809 ENSPTRP00000063809
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HES1Hes family bHLH transcription factor 1. (280 aa)
PHACTR4Phosphatase and actin regulator. (712 aa)
ENSPTRP00000064416annotation not available (502 aa)
FOXC1FOXC1 isoform 1. (550 aa)
SEMA3ESEMA3E isoform 1; Belongs to the semaphorin family. (775 aa)
ENSPTRP00000066737annotation not available (186 aa)
SEMA6ASEMA6A isoform 2; Belongs to the semaphorin family. (1047 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
TCOF1TCOF1 isoform 1. (1525 aa)
SEMA4ASEMA4A isoform 10; Belongs to the semaphorin family. (761 aa)
LOC45900240S ribosomal protein S7 pseudogene. (189 aa)
EDN3EDN3 isoform 1. (238 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
SEMA4GSEMA4G isoform 3; Belongs to the semaphorin family. (843 aa)
FAM172AFamily with sequence similarity 172, member A. (433 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
ENSPTRP00000078649annotation not available (188 aa)
SEMA3FSEMA3F isoform 2; Belongs to the semaphorin family. (785 aa)
ANXA6Annexin. (788 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
SEMA6DSema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6D; Belongs to the semaphorin family. (1086 aa)
FBXL17F-box and leucine rich repeat protein 17. (715 aa)
ENSPTRP00000083815annotation not available (125 aa)
LOC104003681Kelch-like protein 12 pseudogene. (535 aa)
SEMA3BSEMA3B isoform 2; Belongs to the semaphorin family. (749 aa)
ENSPTRP00000087014annotation not available (777 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
LAMA5Laminin, alpha 5. (2203 aa)
EFNB1EFNB1 isoform 1; Belongs to the ephrin family. (346 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
SOX11Transcription factor SOX. (441 aa)
ENSPTRP00000091667annotation not available (191 aa)
NRG1NRG1 isoform 3. (713 aa)
OVOL2Ovo like zinc finger 2. (275 aa)
CDH2Cadherin 2, type 1, N-cadherin (Neuronal); Cadherins are calcium-dependent cell adhesion proteins. (914 aa)
ENSPTRP00000074987annotation not available (189 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
PEF1Penta-EF-hand domain containing 1. (284 aa)
SEMA6CSEMA6C isoform 2; Belongs to the semaphorin family. (962 aa)
KLHL12Kelch like family member 12. (568 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FOLR1Folate receptor alpha. (257 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
ALX1ALX homeobox 1. (326 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (527 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
GSCHomeobox protein goosecoid; Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity); Belongs to the paired homeobox family. Bicoid subfamily. (257 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
SEMA7ASEMA7A isoform 1; Belongs to the semaphorin family. (664 aa)
SEMA4BSEMA4B isoform 1; Belongs to the semaphorin family. (836 aa)
SOX8SOX8 isoform 1. (446 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SEMA6BSema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6B; Belongs to the semaphorin family. (888 aa)
NRTNNRTN isoform 1. (197 aa)
RPS740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
SEMA4CSEMA4C isoform 2; Belongs to the semaphorin family. (833 aa)
FRZBFrizzled-related protein. (325 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
TBX1TBX1 isoform 1. (478 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
SEMA3GSEMA3G isoform 2; Belongs to the semaphorin family. (782 aa)
KBTBD8Kelch repeat and BTB domain containing 8. (601 aa)
SEMA5BSEMA5B isoform 1. (1352 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
PITX2Homeobox protein. (324 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SEMA5ASEMA5A isoform 1. (1074 aa)
ISL1ISL LIM homeobox 1. (349 aa)
EDN1EDN1 isoform 1. (212 aa)
SEMA3CSEMA3C isoform 1; Belongs to the semaphorin family. (751 aa)
SEMA3ASEMA3A isoform 1; Belongs to the semaphorin family. (771 aa)
SEMA3DSEMA3D isoform 1; Belongs to the semaphorin family. (777 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
RDH10Retinol dehydrogenase 10 (All-trans); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
OTUD5OTU deubiquitinase 5. (598 aa)
SOX10SRY-box transcription factor 10. (466 aa)
FN1FN1 isoform 1. (2477 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (701 aa)
SEMA4FSEMA4F isoform 1; Belongs to the semaphorin family. (770 aa)
TWIST1TWIST1 isoform 2. (163 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
SEMA4DSEMA4D isoform 13; Belongs to the semaphorin family. (862 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ENSPTRP00000055426annotation not available (200 aa)
RADILRap associating with DIL domain. (1075 aa)
TAPT1Transmembrane anterior posterior transformation 1. (664 aa)
ERBB4Receptor protein-tyrosine kinase. (1386 aa)
LOC73564540S ribosomal protein S7 pseudogene. (177 aa)
ENSPTRP00000063809annotation not available (177 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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