STRINGSTRING
SLC26A3 SLC26A3 PTAFR PTAFR HSPA5 HSPA5 CASQ2 CASQ2 HMGCS2 HMGCS2 HCN3 HCN3 PTGS2 PTGS2 ADSS2 ADSS2 FOSL1 FOSL1 P2RY2 P2RY2 P2RY6 P2RY6 PANX1 PANX1 BIRC2 BIRC2 FDX1 FDX1 RAPGEF3 RAPGEF3 WNT10B WNT10B GPD1 GPD1 ATF1 ATF1 MMP19 MMP19 LOC744940 LOC744940 P2RX4 P2RX4 AKAP6 AKAP6 DUOX2 DUOX2 AQP9 AQP9 HCN4 HCN4 CIB2 CIB2 AQP8 AQP8 TRPV1 TRPV1 P2RX1 P2RX1 SLC6A4 SLC6A4 COL1A1 COL1A1 AANAT AANAT GATA6 GATA6 BSG BSG TMEM38A TMEM38A SLC5A5 SLC5A5 TRPM4 TRPM4 CYP1B1 CYP1B1 IL1B IL1B IGFBP5 IGFBP5 OXT OXT THBD THBD P2RX6 P2RX6 ADORA2A ADORA2A PDXP PDXP ITPR2 ITPR2 SLC6A1 SLC6A1 SLC26A6 SLC26A6 XRN1 XRN1 P2RY1 P2RY1 ADIPOQ ADIPOQ PKD2 PKD2 SLC6A3 SLC6A3 SRD5A1 SRD5A1 HCN1 HCN1 NDUFS4 NDUFS4 CRHBP CRHBP CDO1 CDO1 BCKDHB BCKDHB NT5E NT5E AKAP7 AKAP7 AQP1 AQP1 CFTR CFTR PAX4 PAX4 STC1 STC1 PTK2B PTK2B PLAT PLAT PENK PENK ASS1 ASS1 CITED1 CITED1 INPP5K INPP5K DMTN DMTN CARM1 CARM1 PDE3A PDE3A PIK3CG PIK3CG PDE2A PDE2A AKAP9 AKAP9 PRKAA1 PRKAA1 KCNJ11 KCNJ11 P2RY11 P2RY11 ENPP1 ENPP1 HDAC2 HDAC2 P2RX7 P2RX7 ASPH ASPH P2RX5 P2RX5 TRPC3 TRPC3 PKLR PKLR CK820_G0015936 CK820_G0015936 P2RY4 P2RY4 AREG AREG ZFP36L1 ZFP36L1 P2RX3 P2RX3 ENSPTRP00000061732 ENSPTRP00000061732 ENSPTRP00000062039 ENSPTRP00000062039 CK820_G0021700 CK820_G0021700 CK820_G0042363 CK820_G0042363 KDM1A KDM1A SLC8A1 SLC8A1 PER1 PER1 RYR2 RYR2 AKAP9-2 AKAP9-2 DUOX1 DUOX1 SDC1 SDC1 ENSPTRP00000066774 ENSPTRP00000066774 CHEK1 CHEK1 PDE4D PDE4D TRPM2 TRPM2 LOC457015 LOC457015 ENSPTRP00000068916 ENSPTRP00000068916 RAP1B RAP1B LOC461877 LOC461877 LOC100609621 LOC100609621 ENSPTRP00000071015 ENSPTRP00000071015 CREB1 CREB1 ENSPTRP00000073414 ENSPTRP00000073414 ADA ADA RAPGEF1 RAPGEF1 ENSPTRP00000074534 ENSPTRP00000074534 CACNA1S CACNA1S SREBF1 SREBF1 ENSPTRP00000076429 ENSPTRP00000076429 PPARG PPARG PPARGC1B PPARGC1B HSP90B1 HSP90B1 LOC107971060 LOC107971060 FOS FOS RAPGEF2 RAPGEF2 CK820_G0013720 CK820_G0013720 PFKFB1 PFKFB1 CNGA3 CNGA3 RPLP0 RPLP0 DGKQ DGKQ P2RX2 P2RX2 ENSPTRP00000083520 ENSPTRP00000083520 PNPT1 PNPT1 ABCC9 ABCC9 RAP1A RAP1A ENSPTRP00000085296 ENSPTRP00000085296 FOSB FOSB SELENON SELENON GATA1 GATA1 CPS1 CPS1 WT1 WT1 KCNQ1 KCNQ1 HCN2 HCN2 TMEM38B TMEM38B EEF2K EEF2K ENSPTRP00000089993 ENSPTRP00000089993 SSH1 SSH1 TAF1 TAF1 CK820_G0030361 CK820_G0030361 CREM CREM INHBB INHBB STAT1 STAT1 RPLP0-2 RPLP0-2 RYR3 RYR3 ENSPTRP00000091352 ENSPTRP00000091352 ENSPTRP00000092145 ENSPTRP00000092145 RYR1 RYR1 EZR EZR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC26A3Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (762 aa)
PTAFRPlatelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa)
HSPA5Heat shock 70kDa protein 5 (Glucose-regulated protein, 78kDa); Belongs to the heat shock protein 70 family. (654 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
HCN3Hyperpolarization activated cyclic nucleotide gated potassium channel 3. (774 aa)
PTGS2Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase). (604 aa)
ADSS2ADSS isoform 1. (456 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
P2RY2Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. (377 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
PANX1Pannexin; Structural component of the gap junctions and the hemichannels. (426 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
FDX1FDX1 isoform 1. (184 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
ATF1Activating transcription factor 1. (270 aa)
MMP19Matrix metallopeptidase 19. (505 aa)
LOC74494060S acidic ribosomal protein P0-like. (315 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (346 aa)
AKAP6A-kinase anchoring protein 6. (2319 aa)
DUOX2DUOX2 isoform 1. (1548 aa)
AQP9AQP9 isoform 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (295 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1203 aa)
CIB2Calcium and integrin binding family member 2. (187 aa)
AQP8AQP8 isoform 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (261 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
AANATSerotonin N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin (By similarity); Belongs to the acetyltransferase family. AANAT subfamily. (207 aa)
GATA6GATA binding protein 6. (594 aa)
BSGBSG isoform 8. (383 aa)
TMEM38ATransmembrane protein 38A. (299 aa)
SLC5A5Solute carrier family 5 member 5; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (643 aa)
TRPM4Transient receptor potential cation channel, subfamily M, member 4. (1306 aa)
CYP1B1Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (543 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (272 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
THBDTHBD isoform 1. (631 aa)
P2RX6P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (441 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
PDXPPyridoxal (Pyridoxine, vitamin B6) phosphatase; Belongs to the HAD-like hydrolase superfamily. (296 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (599 aa)
SLC26A6Solute carrier family 26, member 6. (761 aa)
XRN15'-3' exoribonuclease 1. (1706 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (968 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (259 aa)
HCN1HCN1 isoform 1. (886 aa)
NDUFS4NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (175 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
CDO1Cysteine dioxygenase. (200 aa)
BCKDHBBCKDHB isoform 1. (378 aa)
NT5E5'-nucleotidase, ecto (CD73); Belongs to the 5'-nucleotidase family. (574 aa)
AKAP7A-kinase anchoring protein 7. (348 aa)
AQP1Aquaporin-1 isoform X2. (269 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1480 aa)
PAX4PAX4 isoform 1. (351 aa)
STC1Stanniocalcin 1. (247 aa)
PTK2BPTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (649 aa)
PENKPENK isoform 3. (267 aa)
ASS1Argininosuccinate synthetase 1. (412 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (448 aa)
DMTNDematin actin binding protein. (405 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (608 aa)
PDE3APhosphodiesterase. (1141 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
PDE2APhosphodiesterase. (941 aa)
AKAP9A kinase (PRKA) anchor protein (Yotiao) 9. (3908 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
P2RY11Purinergic receptor P2Y11. (374 aa)
ENPP1ENPP1 isoform 1. (925 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
ASPHASPH isoform 1. (762 aa)
P2RX5P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (431 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (921 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
CK820_G0015936C12orf76 isoform 1. (107 aa)
P2RY4Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. (365 aa)
AREGAREG isoform 2. (274 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
ENSPTRP00000061732annotation not available (285 aa)
ENSPTRP00000062039annotation not available (397 aa)
CK820_G0021700RPLP0 isoform 4. (308 aa)
CK820_G0042363TRPM4 isoform 1. (1251 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
PER1Period circadian regulator 1. (1290 aa)
RYR2RYR2 isoform 1. (4941 aa)
AKAP9-2A-kinase anchoring protein 9. (3896 aa)
DUOX1DUOX1 isoform 1. (1551 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
ENSPTRP00000066774annotation not available (175 aa)
CHEK1CHEK1 isoform 10. (485 aa)
PDE4DPhosphodiesterase. (809 aa)
TRPM2TRPM2 isoform 4. (1393 aa)
LOC457015LOW QUALITY PROTEIN: endoplasmin-like. (448 aa)
ENSPTRP00000068916annotation not available (99 aa)
RAP1BRas-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
LOC461877Argininosuccinate synthase pseudogene. (389 aa)
LOC100609621Argininosuccinate synthase pseudogene. (245 aa)
ENSPTRP00000071015annotation not available (408 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ENSPTRP00000073414annotation not available (393 aa)
ADAAdenosine deaminase. (412 aa)
RAPGEF1RAPGEF1 isoform 5. (1065 aa)
ENSPTRP00000074534annotation not available (441 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
SREBF1SREBF1 isoform 6. (1177 aa)
ENSPTRP00000076429annotation not available (110 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
PPARGC1BPPARGC1B isoform 2. (1023 aa)
HSP90B1Heat shock protein 90 beta family member 1. (814 aa)
LOC107971060SRD5A1 isoform 2. (141 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
RAPGEF2RAPGEF2 isoform 2. (1701 aa)
CK820_G0013720HCN2 isoform 1. (847 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa)
CNGA3Cyclic nucleotide gated channel subunit alpha 3. (698 aa)
RPLP060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (317 aa)
DGKQDiacylglycerol kinase. (952 aa)
P2RX2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (497 aa)
ENSPTRP00000083520annotation not available (273 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (784 aa)
ABCC9ATP-binding cassette, sub-family C (CFTR/MRP), member 9. (1549 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
ENSPTRP00000085296Uncharacterized protein LOC107966511 isoform X1. (87 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
SELENONT0161445 isoform 2. (581 aa)
GATA1GATA binding protein 1. (413 aa)
CPS1Carbamoyl-phosphate synthase 1, mitochondrial. (1507 aa)
WT1WT1 transcription factor. (514 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (775 aa)
TMEM38BTransmembrane protein 38B. (297 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
ENSPTRP00000089993annotation not available (58 aa)
SSH1Slingshot homolog 1. (1062 aa)
TAF1Transcription initiation factor TFIID subunit. (1927 aa)
CK820_G0030361RYR1 isoform 5. (4901 aa)
CREMcAMP responsive element modulator. (345 aa)
INHBBInhibin subunit beta B. (407 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
RPLP0-2Ribosomal protein lateral stalk subunit P0. (317 aa)
RYR3Ryanodine receptor 3. (4873 aa)
ENSPTRP00000091352annotation not available (87 aa)
ENSPTRP00000092145annotation not available (318 aa)
RYR1RYR1 isoform 3. (5037 aa)
EZREZR isoform 1. (671 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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