STRINGSTRING
TNNI3 TNNI3 NOX4 NOX4 PRKAR1A PRKAR1A IFRD1 IFRD1 AKAP13 AKAP13 TPM1 TPM1 LRRC10 LRRC10 GJB6 GJB6 MSC MSC TAZ TAZ NOTCH1 NOTCH1 ENG ENG PGM5 PGM5 FOXH1 FOXH1 PLEC PLEC EYA1 EYA1 CHD7 CHD7 NKX2-6 NKX2-6 SGCZ SGCZ WNT2 WNT2 MYL10 MYL10 SEMA3C SEMA3C MYL7 MYL7 TBX20 TBX20 HEY2 HEY2 ATG5 ATG5 BVES BVES TBX18 TBX18 BMP5 BMP5 SRF SRF DSP DSP NKX2-5 NKX2-5 HAND1 HAND1 PTCD2 PTCD2 ISL1 ISL1 SORBS2 SORBS2 EDNRA EDNRA SMAD1 SMAD1 SGCB SGCB VWA5B2 VWA5B2 DIPK2A DIPK2A HEG1 HEG1 ADAMTS9 ADAMTS9 TNNC1 TNNC1 MYL3 MYL3 CAV3 CAV3 CXADR CXADR BMP7 BMP7 MYLK2 MYLK2 BMP2 BMP2 TTN TTN LRP2 LRP2 ID2 ID2 PPP1R13L PPP1R13L TGFB1 TGFB1 CALR CALR SIRT6 SIRT6 ALPK2 ALPK2 SMAD4 SMAD4 SMAD7 SMAD7 DSG2 DSG2 GATA6 GATA6 TBX2 TBX2 NOG NOG TCAP TCAP MED1 MED1 MYOCD MYOCD MAP2K4 MAP2K4 ZFPM1 ZFPM1 NDRG4 NDRG4 IRX3 IRX3 MYLK3 MYLK3 MESP1 MESP1 HCN4 HCN4 ALDH1A2 ALDH1A2 ASB2 ASB2 BMP4 BMP4 SAV1 SAV1 SGCG SGCG FGF9 FGF9 ARID2 ARID2 PKP2 PKP2 VWA5A VWA5A TENM4 TENM4 MYBPC3 MYBPC3 CSRP3 CSRP3 FGFR2 FGFR2 NRAP NRAP ANKRD1 ANKRD1 BMPR1A BMPR1A NEBL NEBL TGFB2 TGFB2 TNNI1 TNNI1 LMNA LMNA POU4F1 POU4F1 VWA5B1 VWA5B1 NPPB NPPB NPPA NPPA MTOR MTOR NPRL3 NPRL3 BMP10 BMP10 CDC42 CDC42 IFT20 IFT20 MYL10-2 MYL10-2 PDLIM5 PDLIM5 PLN PLN GATA4 GATA4 NOTCH2 NOTCH2 ACVR1 ACVR1 SHH SHH ZFPM2 ZFPM2 GATA5 GATA5 MAPK11 MAPK11 TGFBR1 TGFBR1 NEB NEB ENSPTRP00000072925 ENSPTRP00000072925 ENSPTRP00000071968 ENSPTRP00000071968 ENSPTRP00000071419 ENSPTRP00000071419 TNNT2 TNNT2 CBY1 CBY1 MEF2A MEF2A DLL4 DLL4 ITGB1 ITGB1 SCN5A SCN5A HEY1 HEY1 TBX5 TBX5 LRRC10B LRRC10B MYO18B MYO18B PRMT1 PRMT1 JARID2 JARID2 SLC9A1 SLC9A1 LOC736481 LOC736481 ENSPTRP00000066578 ENSPTRP00000066578 ZIC3 ZIC3 TGFBR3 TGFBR3 HOPX HOPX CACNA1G CACNA1G ENSPTRP00000065655 ENSPTRP00000065655 C10H10orf113 C10H10orf113 FOXC1 FOXC1 RYR2 RYR2 ENSPTRP00000064416 ENSPTRP00000064416 SLC8A1 SLC8A1 MYH11 MYH11 CXADR-2 CXADR-2 TSC1 TSC1 ALPK3 ALPK3 EGLN1 EGLN1 S1PR1 S1PR1 KDM6B KDM6B SGCD SGCD TREX1 TREX1 OBSL1 OBSL1 MAML1 MAML1 IFRD2 IFRD2 FOXC2 FOXC2 RARA RARA FOXH1-2 FOXH1-2 ENSPTRP00000093588 ENSPTRP00000093588 ENSPTRP00000093210 ENSPTRP00000093210 LOC100612629 LOC100612629 ENSPTRP00000093022 ENSPTRP00000093022 ENSPTRP00000092784 ENSPTRP00000092784 EYA2 EYA2 NRG1 NRG1 ADPRHL1 ADPRHL1 SHOX2 SHOX2 CK820_G0054677 CK820_G0054677 PTEN PTEN MEF2C MEF2C MYH6 MYH6 COL11A1 COL11A1 WNT8A WNT8A WT1 WT1 GJA5 GJA5 FHL2 FHL2 WNT5A WNT5A HNRNPU HNRNPU TBX3 TBX3 ADRA1A ADRA1A ENSPTRP00000084126 ENSPTRP00000084126 RARB RARB MYH7 MYH7 BMP4-2 BMP4-2 GJC1 GJC1 ZMPSTE24 ZMPSTE24 SMAD5 SMAD5 PDGFRB PDGFRB FHOD3 FHOD3 ACTN2 ACTN2 MYL2 MYL2 RBPJ RBPJ ACADM ACADM PROX1 PROX1 WNT3A WNT3A CDK1 CDK1 XIRP2 XIRP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNNI3TNNI3 isoform 2. (169 aa)
NOX4NADPH oxidase 4. (578 aa)
PRKAR1AProtein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1). (381 aa)
IFRD1Interferon-related developmental regulator 1. (452 aa)
AKAP13A-kinase anchoring protein 13. (2813 aa)
TPM1TPM1 isoform 3; Belongs to the tropomyosin family. (326 aa)
LRRC10Leucine rich repeat containing 10. (277 aa)
GJB6Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (228 aa)
MSCMSC isoform 1. (295 aa)
TAZTafazzin; Some isoforms may be involved in cardiolipin metabolism; Belongs to the taffazin family. (286 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ENGENG isoform 1. (658 aa)
PGM5Uncharacterized protein; Belongs to the phosphohexose mutase family. (567 aa)
FOXH1FOXH1 isoform 1. (365 aa)
PLECPLEC isoform 2. (4684 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
CHD7CHD7 isoform 1. (2997 aa)
NKX2-6NKX2-6 isoform 1. (301 aa)
SGCZSarcoglycan zeta. (312 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
MYL10ADCY7 isoform 13. (226 aa)
SEMA3CSEMA3C isoform 1; Belongs to the semaphorin family. (751 aa)
MYL7Myosin light chain 7. (175 aa)
TBX20T-box transcription factor 20. (447 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
BVESBlood vessel epicardial substance. (360 aa)
TBX18T-box transcription factor 18. (607 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
DSPDSP isoform 1. (2871 aa)
NKX2-5NKX2-5 isoform 1. (325 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
PTCD2Pentatricopeptide repeat domain 2. (388 aa)
ISL1ISL LIM homeobox 1. (349 aa)
SORBS2Sorbin and SH3 domain containing 2. (1202 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SMAD1Mothers against decapentaplegic homolog. (469 aa)
SGCBSarcoglycan beta. (320 aa)
VWA5B2VWA5B2 isoform 1. (1253 aa)
DIPK2AChromosome 3 open reading frame 58. (430 aa)
HEG1HEG1 isoform 1. (1381 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1935 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
MYL3Myosin, light chain 3, alkali ventricular, skeletal, slow. (224 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
CXADRCXADR Ig-like cell adhesion molecule. (365 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
MYLK2MYLK2 isoform 1. (596 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
TTNTTN isoform 3. (32000 aa)
LRP2LRP2 isoform 1. (4655 aa)
ID2Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein. (134 aa)
PPP1R13LProtein phosphatase 1 regulatory subunit 13 like. (828 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CALRCalreticulin. (414 aa)
SIRT6SIRT6 isoform 1. (355 aa)
ALPK2ALPK2 isoform 1. (2171 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
DSG2DSG2 isoform 1. (1118 aa)
GATA6GATA binding protein 6. (594 aa)
TBX2T-box transcription factor 2. (712 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TCAPTCAP isoform 1. (167 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
MYOCDMYOCD isoform 2. (986 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
ZFPM1ZFPM1 isoform 1. (974 aa)
NDRG4NDRG family member 4. (226 aa)
IRX3Iroquois homeobox 3. (500 aa)
MYLK3MYLK3 isoform 1. (819 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (268 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1203 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (635 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
SGCGSarcoglycan, gamma (35kDa dystrophin-associated glycoprotein). (291 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ARID2AT-rich interaction domain 2. (1835 aa)
PKP2PKP2 isoform 1. (837 aa)
VWA5AVon Willebrand factor A domain containing 5A. (785 aa)
TENM4Teneurin transmembrane protein 4. (2769 aa)
MYBPC3Myosin binding protein C, cardiac. (1274 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
NRAPNRAP isoform 1. (1730 aa)
ANKRD1Ankyrin repeat domain 1 (Cardiac muscle). (319 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NEBLNEBL isoform 5. (1014 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TNNI1Troponin I type 1 (Skeletal, slow). (187 aa)
LMNALMNA isoform 8; Belongs to the intermediate filament family. (664 aa)
POU4F1POU domain protein. (350 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1215 aa)
NPPBNatriuretic peptide B. (134 aa)
NPPANatriuretic peptide A. (153 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
NPRL3Nitrogen permease regulator-like 3. (556 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
IFT20IFT20 isoform 5. (164 aa)
MYL10-2MYL10 isoform 1. (226 aa)
PDLIM5PDLIM5 isoform 14. (625 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
GATA4GATA binding protein 4. (443 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
ZFPM2ZFPM2 isoform 3. (1151 aa)
GATA5GATA binding protein 5. (397 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
NEBNEB isoform 5. (8417 aa)
ENSPTRP00000072925annotation not available (372 aa)
ENSPTRP00000071968annotation not available (115 aa)
ENSPTRP00000071419annotation not available (371 aa)
TNNT2Troponin T type 2 (Cardiac). (298 aa)
CBY1Chibby family member 1, beta catenin antagonist. (169 aa)
MEF2AMyocyte enhancer factor 2A. (507 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
TBX5T-box transcription factor 5. (518 aa)
LRRC10BLeucine rich repeat containing 10B. (292 aa)
MYO18BMYO18B isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2550 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1246 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
LOC736481Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (400 aa)
ENSPTRP00000066578annotation not available (310 aa)
ZIC3Zic family member 3. (466 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
HOPXHOPX isoform 3. (112 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
ENSPTRP00000065655annotation not available (349 aa)
C10H10orf113C10orf113 isoform 2. (79 aa)
FOXC1FOXC1 isoform 1. (550 aa)
RYR2RYR2 isoform 1. (4941 aa)
ENSPTRP00000064416annotation not available (502 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
MYH11MYH11 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2009 aa)
CXADR-2CXADR Ig-like cell adhesion molecule. (188 aa)
TSC1TSC complex subunit 1. (1164 aa)
ALPK3ALPK3 isoform 1. (1901 aa)
EGLN1EGLN1 isoform 1. (426 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
KDM6BLysine demethylase 6B. (1679 aa)
SGCDSarcoglycan, delta (35kDa dystrophin-associated glycoprotein). (290 aa)
TREX1Three prime repair exonuclease 1. (369 aa)
OBSL1OBSL1 isoform 6. (1895 aa)
MAML1MAML1 isoform 1. (1016 aa)
IFRD2Interferon-related developmental regulator 2. (510 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
RARARARA isoform 4. (624 aa)
FOXH1-2Forkhead box H1. (365 aa)
ENSPTRP00000093588annotation not available (361 aa)
ENSPTRP00000093210annotation not available (261 aa)
LOC100612629Protein arginine N-methyltransferase 1 pseudogene. (325 aa)
ENSPTRP00000093022annotation not available (563 aa)
ENSPTRP00000092784annotation not available (75 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (538 aa)
NRG1NRG1 isoform 3. (713 aa)
ADPRHL1ADPRHL1 isoform 2. (1673 aa)
SHOX2SHOX2 isoform 2. (343 aa)
CK820_G0054677NPRL3 isoform 10. (74 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
MYH6MYH6 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2050 aa)
COL11A1Collagen type XI alpha 1 chain. (1818 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
WT1WT1 transcription factor. (514 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
FHL2FHL2 isoform 4. (389 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U (Scaffold attachment factor A). (825 aa)
TBX3T-box transcription factor 3. (743 aa)
ADRA1AAdrenoceptor alpha 1A. (495 aa)
ENSPTRP00000084126annotation not available (117 aa)
RARBRetinoic acid receptor, beta. (448 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
GJC1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
FHOD3Formin homology 2 domain containing 3. (1622 aa)
ACTN2ACTN2 isoform 2. (894 aa)
MYL2Myosin, light chain 2, regulatory, cardiac, slow. (166 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
ACADMMedium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). (412 aa)
PROX1Prospero homeobox 1. (737 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
XIRP2XIRP2 isoform 3. (3549 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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