16 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CASQ1	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (396 aa)
	SCN4A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1836 aa)
	KCNJ2	Potassium inwardly-rectifying channel, subfamily J, member 2. (427 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	NR4A1	Nuclear receptor subfamily 4 group A member 1. (652 aa)
	KBTBD13	Kelch repeat and BTB domain containing 13. (458 aa)
	GSTO1	Glutathione S-transferase omega 1. (241 aa)
	DMPK	Dystrophia myotonica-protein kinase. (639 aa)
	DMD	DMD isoform 3. (3685 aa)
	STRIT1	Small transmembrane regulator of ion transport 1. (35 aa)
	MYH7	Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
	ENSPTRP00000082718	annotation not available (235 aa)
	ATP2A1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1068 aa)
	DMD-2	Dystrophin. (643 aa)
	ACTN3	Actinin alpha 3 (gene/pseudogene). (944 aa)
	SLC8A3	Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN3	ATP2A1	ENSPTRP00000086020	ENSPTRP00000082742	Actinin alpha 3 (gene/pseudogene).	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.490
ACTN3	CASQ1	ENSPTRP00000086020	ENSPTRP00000002593	Actinin alpha 3 (gene/pseudogene).	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.619
ACTN3	KBTBD13	ENSPTRP00000086020	ENSPTRP00000060856	Actinin alpha 3 (gene/pseudogene).	Kelch repeat and BTB domain containing 13.	0.417
ACTN3	MYH7	ENSPTRP00000086020	ENSPTRP00000081675	Actinin alpha 3 (gene/pseudogene).	Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.575
ATP2A1	ACTN3	ENSPTRP00000082742	ENSPTRP00000086020	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Actinin alpha 3 (gene/pseudogene).	0.490
ATP2A1	CASQ1	ENSPTRP00000082742	ENSPTRP00000002593	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.666
ATP2A1	DMPK	ENSPTRP00000082742	ENSPTRP00000068273	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Dystrophia myotonica-protein kinase.	0.585
ATP2A1	MYH7	ENSPTRP00000082742	ENSPTRP00000081675	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.532
CASQ1	ACTN3	ENSPTRP00000002593	ENSPTRP00000086020	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Actinin alpha 3 (gene/pseudogene).	0.619
CASQ1	ATP2A1	ENSPTRP00000002593	ENSPTRP00000082742	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.666
CASQ1	MYH7	ENSPTRP00000002593	ENSPTRP00000081675	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.422
CAV3	DMD	ENSPTRP00000025136	ENSPTRP00000069572	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	DMD isoform 3.	0.629
CAV3	DMD-2	ENSPTRP00000025136	ENSPTRP00000084655	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Dystrophin.	0.629
CAV3	KCNJ2	ENSPTRP00000025136	ENSPTRP00000016291	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Potassium inwardly-rectifying channel, subfamily J, member 2.	0.677
CAV3	SCN4A	ENSPTRP00000025136	ENSPTRP00000016195	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.403
DMD	CAV3	ENSPTRP00000069572	ENSPTRP00000025136	DMD isoform 3.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.629
DMD	MYH7	ENSPTRP00000069572	ENSPTRP00000081675	DMD isoform 3.	Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.544
DMD-2	CAV3	ENSPTRP00000084655	ENSPTRP00000025136	Dystrophin.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.629
DMD-2	MYH7	ENSPTRP00000084655	ENSPTRP00000081675	Dystrophin.	Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.544
DMPK	ATP2A1	ENSPTRP00000068273	ENSPTRP00000082742	Dystrophia myotonica-protein kinase.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.585