STRINGSTRING
AIF1 AIF1 ENSPTRP00000093848 ENSPTRP00000093848 ENSPTRP00000092937 ENSPTRP00000092937 ENSPTRP00000092800 ENSPTRP00000092800 BCL2 BCL2 ENSPTRP00000087944 ENSPTRP00000087944 ENSPTRP00000087426 ENSPTRP00000087426 MDK MDK NR4A3 NR4A3 CRK CRK CCL5 CCL5 ITGA2 ITGA2 SEMA6D SEMA6D ENSPTRP00000080971 ENSPTRP00000080971 PDGFRB PDGFRB PDGFD PDGFD SRC SRC DOCK4 DOCK4 ENSPTRP00000072607 ENSPTRP00000072607 DOCK7 DOCK7 DOCK5 DOCK5 ITGB3 ITGB3 IGF1 IGF1 XBP1 XBP1 ATP7A ATP7A LPAR1 LPAR1 TERT TERT HAS2 HAS2 FOXO4 FOXO4 CCN4 CCN4 TERT-2 TERT-2 PDGFB PDGFB ADAMTS1 ADAMTS1 IGFBP5 IGFBP5 CYP1B1 CYP1B1 RPS6KB1 RPS6KB1 FGF9 FGF9 S100A11 S100A11 DDR2 DDR2 NRP1 NRP1 P2RY6 P2RY6 IL18 IL18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AIF1Allograft inflammatory factor 1. (147 aa)
ENSPTRP00000093848annotation not available (96 aa)
ENSPTRP00000092937annotation not available (104 aa)
ENSPTRP00000092800annotation not available (96 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
ENSPTRP00000087944annotation not available (102 aa)
ENSPTRP00000087426annotation not available (104 aa)
MDKMidkine (Neurite growth-promoting factor 2). (143 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
CCL5C-C motif chemokine. (91 aa)
ITGA2Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Belongs to the integrin alpha chain family. (1183 aa)
SEMA6DSema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6D; Belongs to the semaphorin family. (1086 aa)
ENSPTRP00000080971annotation not available (104 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
SRCTyrosine-protein kinase. (542 aa)
DOCK4DOCK4 isoform 6; Belongs to the DOCK family. (2011 aa)
ENSPTRP00000072607annotation not available (104 aa)
DOCK7Dedicator of cytokinesis 7; Belongs to the DOCK family. (2129 aa)
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1881 aa)
ITGB3Integrin beta-3 isoform X2. (837 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
XBP1XBP1 isoform 4. (381 aa)
ATP7AATPase, Cu++ transporting, alpha polypeptide. (1500 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
TERTTelomerase reverse transcriptase. (360 aa)
HAS2Hyaluronan synthase 2. (554 aa)
FOXO4Forkhead box O4. (505 aa)
CCN4WISP1 isoform 1. (367 aa)
TERT-2Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (762 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif, 1. (967 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (272 aa)
CYP1B1Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (543 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
S100A11Protein S100; Belongs to the S-100 family. (105 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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