STRINGSTRING
GRIN3A GRIN3A FARP1 FARP1 DVL1 DVL1 PPP1R9B PPP1R9B ABI2 ABI2 MAP1S MAP1S EPHB3 EPHB3 SLC11A2 SLC11A2 ENSPTRP00000070863 ENSPTRP00000070863 MEF2A MEF2A ENSPTRP00000070307 ENSPTRP00000070307 ITGB1 ITGB1 MINK1 MINK1 FAT3 FAT3 TAOK2 TAOK2 PHACTR1 PHACTR1 PPP3CA PPP3CA DCDC2 DCDC2 DCX DCX CTNND2 CTNND2 DTNBP1 DTNBP1 LST1 LST1 SHANK1 SHANK1 IQSEC1 IQSEC1 KLHL5 KLHL5 BAIAP2 BAIAP2 TMEM106B TMEM106B WNT7A WNT7A ACTL6B-2 ACTL6B-2 SHANK3 SHANK3 CK820_G0054728 CK820_G0054728 ENSPTRP00000063424 ENSPTRP00000063424 DOCK10 DOCK10 PAK3 PAK3 MCF2 MCF2 SLC9A6 SLC9A6 TMEFF1 TMEFF1 SYNGAP1 SYNGAP1 KLF7 KLF7 BBS4 BBS4 RELN RELN EPHB1 EPHB1 ARC ARC EPHB2 EPHB2 DAB1 DAB1 MAP1A MAP1A SRGAP2 SRGAP2 HDAC2 HDAC2 MAPK8IP2 MAPK8IP2 VLDLR VLDLR FLRT1 FLRT1 CRKL CRKL ABI1 ABI1 IGSF9 IGSF9 MAP2 MAP2 KLHL4 KLHL4 HDAC6 HDAC6 ABITRAM ABITRAM SDC2 SDC2 GPR37 GPR37 WASL WASL ACTL6B ACTL6B SEMA3A SEMA3A TPBG TPBG SLC25A46 SLC25A46 MAP1B MAP1B UBA6 UBA6 PAK2 PAK2 ARF4 ARF4 SULT4A1 SULT4A1 DIP2A DIP2A DSCAM DSCAM SS18L1 SS18L1 BMP7 BMP7 BTBD3 BTBD3 NCK2 NCK2 KIDINS220 KIDINS220 NTN5 NTN5 NKPD1 NKPD1 IGF2BP1 IGF2BP1 NTN1 NTN1 DLG4 DLG4 SCARF1 SCARF1 NTN3 NTN3 CHRNA7 CHRNA7 STRN STRN SLITRK5 SLITRK5 CD3E CD3E MAP6 MAP6 BBS1 BBS1 PRMT3 PRMT3 PRKG1 PRKG1 NRP1 NRP1 LAMC2 LAMC2 LRP8 LRP8 ELAVL4 ELAVL4 RERE RERE APP APP ENSPTRP00000093022 ENSPTRP00000093022 TULP1 TULP1 CK820_G0027442 CK820_G0027442 PTEN PTEN PAK4 PAK4 ENSPTRP00000089450 ENSPTRP00000089450 NFATC4 NFATC4 KLHL1 KLHL1 ZNF365 ZNF365 HPRT1 HPRT1 CK820_G0014959 CK820_G0014959 TRAPPC4 TRAPPC4 CELSR2 CELSR2 DCLK1 DCLK1 CRK CRK PICALM PICALM LRP4 LRP4 MECP2 MECP2 PTN PTN CDK5 CDK5 CAMK2A CAMK2A FEZF2 FEZF2 SLC12A5 SLC12A5 GHRL GHRL CDC42 CDC42 FYN FYN ENSPTRP00000077189 ENSPTRP00000077189 GRIP1 GRIP1 MPDZ MPDZ CTNNA2 CTNNA2 PREX2 PREX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRIN3AGRIN3A isoform 1. (1115 aa)
FARP1FERM, ARH/RhoGEF and pleckstrin domain protein 1. (1076 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...] (743 aa)
PPP1R9BProtein phosphatase 1, regulatory (Inhibitor) subunit 9B. (817 aa)
ABI2Abl interactor 2. (513 aa)
MAP1SMAP1S isoform 1. (1063 aa)
EPHB3EPHB3 isoform 1. (1031 aa)
SLC11A2SLC11A2 isoform 1. (590 aa)
ENSPTRP00000070863annotation not available (261 aa)
MEF2AMyocyte enhancer factor 2A. (507 aa)
ENSPTRP00000070307annotation not available (237 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
MINK1Misshapen-like kinase 1. (1333 aa)
FAT3FAT3 isoform 2. (4612 aa)
TAOK2TAOK2 isoform 1. (1235 aa)
PHACTR1Phosphatase and actin regulator. (649 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
DCDC2Doublecortin domain containing 2. (476 aa)
DCXDCX isoform 5. (420 aa)
CTNND2CTNND2 isoform 2. (1250 aa)
DTNBP1Dystrobrevin binding protein 1. (351 aa)
LST1Leukocyte specific transcript 1. (104 aa)
SHANK1SHANK1 isoform 3. (2161 aa)
IQSEC1IQ motif and Sec7 domain 1. (1114 aa)
KLHL5Kelch like family member 5. (757 aa)
BAIAP2BAI1 associated protein 2. (553 aa)
TMEM106BTransmembrane protein 106B. (279 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
ACTL6B-2Actin like 6B. (426 aa)
SHANK3SHANK3 isoform 2. (1744 aa)
CK820_G0054728MECP2 isoform 14. (493 aa)
ENSPTRP00000063424annotation not available (1563 aa)
DOCK10Dedicator of cytokinesis 10; Belongs to the DOCK family. (2193 aa)
PAK3Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...] (580 aa)
MCF2MCF2 isoform 7. (1044 aa)
SLC9A6Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (701 aa)
TMEFF1Transmembrane protein with EGF like and two follistatin like domains 1. (454 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1345 aa)
KLF7Kruppel-like factor 7 (Ubiquitous). (302 aa)
BBS4Bardet-Biedl syndrome 4. (519 aa)
RELNRELN isoform 3. (3460 aa)
EPHB1EPH receptor B1. (984 aa)
ARCActivity-regulated cytoskeleton-associated protein. (396 aa)
EPHB2EPH receptor B2. (1055 aa)
DAB1DAB adaptor protein 1. (588 aa)
MAP1AMicrotubule associated protein 1A. (3041 aa)
SRGAP2SRGAP2 isoform 1. (1071 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
MAPK8IP2MAPK8IP2 isoform 2. (824 aa)
VLDLRVery low density lipoprotein receptor. (874 aa)
FLRT1Fibronectin leucine rich transmembrane protein 1. (674 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
ABI1Abl interactor 1. (508 aa)
IGSF9Immunoglobulin superfamily member 9. (1179 aa)
MAP2Microtubule-associated protein. (1827 aa)
KLHL4Kelch like family member 4. (718 aa)
HDAC6Histone deacetylase 6. (146 aa)
ABITRAMFAM206A isoform 2. (181 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
GPR37G protein-coupled receptor 37. (613 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
ACTL6BACTL6B isoform 1; Belongs to the actin family. (426 aa)
SEMA3ASEMA3A isoform 1; Belongs to the semaphorin family. (771 aa)
TPBGTrophoblast glycoprotein. (420 aa)
SLC25A46Solute carrier family 25, member 46; Belongs to the mitochondrial carrier (TC 2.A.29) family. (418 aa)
MAP1BMicrotubule associated protein 1B. (2468 aa)
UBA6Ubiquitin-like modifier-activating enzyme 6. (1052 aa)
PAK2Non-specific serine/threonine protein kinase. (476 aa)
ARF4ADP-ribosylation factor 4; Belongs to the small GTPase superfamily. Arf family. (180 aa)
SULT4A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (284 aa)
DIP2ADIP2 disco-interacting protein 2 homolog A. (1571 aa)
DSCAMDS cell adhesion molecule. (2012 aa)
SS18L1Synovial sarcoma translocation gene on chromosome 18-like 1. (396 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
BTBD3BTB (POZ) domain containing 3. (522 aa)
NCK2Cytoplasmic protein. (380 aa)
KIDINS220Kinase D interacting substrate 220. (1771 aa)
NTN5NTN5 isoform 1. (489 aa)
NKPD1NTPase KAP family P-loop domain containing 1. (612 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (577 aa)
NTN1NTN1 isoform 1. (604 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
SCARF1Scavenger receptor class F, member 1. (830 aa)
NTN3NTN3 isoform 1. (580 aa)
CHRNA7CHRNA7 isoform 7. (511 aa)
STRNStriatin, calmodulin binding protein. (780 aa)
SLITRK5SLIT and NTRK like family member 5. (958 aa)
CD3ECD3E isoform 2. (207 aa)
MAP6Microtubule associated protein 6. (815 aa)
BBS1Bardet-Biedl syndrome 1 protein isoform X1. (593 aa)
PRMT3Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (531 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
LAMC2LAMC2 isoform 1. (1193 aa)
LRP8LDL receptor related protein 8. (960 aa)
ELAVL4ELAV-like protein; Belongs to the RRM elav family. (402 aa)
REREArginine-glutamic acid dipeptide (RE) repeats. (1566 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (771 aa)
ENSPTRP00000093022annotation not available (563 aa)
TULP1Tubby-like protein; Belongs to the TUB family. (542 aa)
CK820_G0027442SULT4A1 isoform 3. (75 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PAK4Non-specific serine/threonine protein kinase. (593 aa)
ENSPTRP00000089450annotation not available (303 aa)
NFATC4Nuclear factor of activated T cells 4. (933 aa)
KLHL1Kelch like family member 1. (748 aa)
ZNF365Zinc finger protein 365. (407 aa)
HPRT1Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). (218 aa)
CK820_G0014959KLF7 isoform 7. (258 aa)
TRAPPC4Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (257 aa)
CELSR2CELSR2 isoform 1; Belongs to the G-protein coupled receptor 2 family. (2925 aa)
DCLK1Doublecortin like kinase 1. (740 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (674 aa)
LRP4Low density lipoprotein receptor-related protein 4. (1906 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
PTNPTN isoform 2. (172 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
FEZF2FEZ family zinc finger 2. (463 aa)
SLC12A5Solute carrier family 12 member 5. (1139 aa)
GHRLGHRL isoform 10. (117 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
FYNTyrosine-protein kinase. (537 aa)
ENSPTRP00000077189annotation not available (276 aa)
GRIP1Glutamate receptor interacting protein 1. (1128 aa)
MPDZMultiple PDZ domain crumbs cell polarity complex component. (2084 aa)
CTNNA2CTNNA2 isoform 11. (953 aa)
PREX2Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1620 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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