(57 nodes) Cyclin-dependent protein serine/threonine kinase regulator activity network (Pan troglodytes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Your Input:
	CCNE2	CCNE2 isoform 1; Belongs to the cyclin family. (404 aa)
	CDKN2C	Cyclin-dependent kinase inhibitor 2C (P18, inhibits CDK4). (168 aa)
	CKS1B	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	CCNJ	CCNJ isoform 2; Belongs to the cyclin family. (383 aa)
	CCND2	CCND2 isoform 1; Belongs to the cyclin family. (289 aa)
	CDKN1B	Cyclin-dependent kinase inhibitor 1B (P27, Kip1). (198 aa)
	CCNT1	Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of SIV infection, binds to the nuclear transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing [...] (725 aa)
	CCNB2	CCNB2 isoform 1; Belongs to the cyclin family. (398 aa)
	HEXIM2	Hexamthylene bis-acetamide inducible 2. (286 aa)
	CDKN2D	Cyclin dependent kinase inhibitor 2D. (166 aa)
	CNTD2	Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (307 aa)
	DRICH1	DRICH1 isoform 1. (227 aa)
	KAT2B	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
	CCNL1	CCNL1 isoform 3; Belongs to the cyclin family. (526 aa)
	CCNI	CCNI isoform 1; Belongs to the cyclin family. (377 aa)
	CCNG2	CCNG2 isoform 1; Belongs to the cyclin family. (344 aa)
	CCNA2	CCNA2 isoform 1; Belongs to the cyclin family. (432 aa)
	CCNO	CCNO isoform 2; Belongs to the cyclin family. (350 aa)
	CCNB1	CCNB1 isoform 1; Belongs to the cyclin family. (433 aa)
	CCNJL	CCNJL isoform 1; Belongs to the cyclin family. (435 aa)
	CCNG1	CCNG1 isoform 2; Belongs to the cyclin family. (295 aa)
	CCNC	CCNC isoform 1; Belongs to the cyclin family. (283 aa)
	CKS2	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	CDK4	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
	CCNT2	CCNT2 isoform 4; Belongs to the cyclin family. (730 aa)
	CCNL2	CCNL2 isoform 3; Belongs to the cyclin family. (521 aa)
	CNPPD1	Cyclin Pas1/PHO80 domain containing 1. (410 aa)
	LOC739971	Cyclin-Y-like protein 2. (358 aa)
	CCNI2	Cyclin I family member 2; Belongs to the cyclin family. (385 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator. (307 aa)
	CASP3	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
	CCNF	CCNF isoform 1; Belongs to the cyclin family. (786 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa)
	ENSPTRP00000061568	annotation not available (353 aa)
	CCNK	CCNK isoform 2; Belongs to the cyclin family. (572 aa)
	CCNB3	CCNB3 isoform 4; Belongs to the cyclin family. (1396 aa)
	CCND3	CCND3 isoform 1; Belongs to the cyclin family. (292 aa)
	HEXIM1	Hexamethylene bis-acetamide inducible 1. (359 aa)
	ENSPTRP00000069619	annotation not available (333 aa)
	CCNA1	CCNA1 isoform 3; Belongs to the cyclin family. (421 aa)
	INCA1	INCA1 isoform 3. (236 aa)
	CCNQ	Family with sequence similarity 58, member A; Belongs to the cyclin family. (248 aa)
	ENSPTRP00000075658	annotation not available (79 aa)
	CCNY	CCNY isoform 4; Belongs to the cyclin family. (383 aa)
	CDKN2A	Cyclin-dependent kinase inhibitor 2A (Melanoma, p16, inhibits CDK4). (173 aa)
	CCNYL1	CCNYL1 isoform 3; Belongs to the cyclin family. (359 aa)
	ENSPTRP00000078561	annotation not available (79 aa)
	ENSPTRP00000080848	annotation not available (88 aa)
	SOWAHB	Sosondowah ankyrin repeat domain family member B. (793 aa)
	CDKN2B	Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4). (138 aa)
	CCND1	CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
	CCNE1	CCNE1 isoform 1; Belongs to the cyclin family. (411 aa)
	CDK5R2	Cyclin-dependent kinase 5 activator. (367 aa)
	CDKN1C	CDKN1C isoform 1. (288 aa)
	ENSPTRP00000091457	annotation not available (64 aa)
	CCNH	CCNH isoform 1; Belongs to the cyclin family. (325 aa)
	MNAT1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	CCNA1	ENSPTRP00000054330	ENSPTRP00000070605	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	CCNA1 isoform 3; Belongs to the cyclin family.	0.546
CASP3	CCNA2	ENSPTRP00000054330	ENSPTRP00000028181	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	CCNA2 isoform 1; Belongs to the cyclin family.	0.550
CASP3	CCNB1	ENSPTRP00000054330	ENSPTRP00000029014	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	CCNB1 isoform 1; Belongs to the cyclin family.	0.680
CASP3	CCNB2	ENSPTRP00000054330	ENSPTRP00000012178	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	CCNB2 isoform 1; Belongs to the cyclin family.	0.458
CASP3	CCND1	ENSPTRP00000054330	ENSPTRP00000086048	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	CCND1 isoform 1; Belongs to the cyclin family.	0.661
CASP3	CCNE1	ENSPTRP00000054330	ENSPTRP00000087725	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	CCNE1 isoform 1; Belongs to the cyclin family.	0.417
CASP3	CCNL2	ENSPTRP00000054330	ENSPTRP00000041901	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	CCNL2 isoform 3; Belongs to the cyclin family.	0.470
CASP3	CDK4	ENSPTRP00000054330	ENSPTRP00000039845	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.	0.661
CASP3	CDKN1A	ENSPTRP00000054330	ENSPTRP00000060292	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Cyclin-dependent kinase inhibitor 1A (P21, Cip1).	0.991
CASP3	CDKN1B	ENSPTRP00000054330	ENSPTRP00000008044	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Cyclin-dependent kinase inhibitor 1B (P27, Kip1).	0.674
CASP3	CDKN1C	ENSPTRP00000054330	ENSPTRP00000090407	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	CDKN1C isoform 1.	0.409
CASP3	CNTD2	ENSPTRP00000054330	ENSPTRP00000018853	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Cyclin N-terminal domain containing 2; Belongs to the cyclin family.	0.458
CASP3	ENSPTRP00000061568	ENSPTRP00000054330	ENSPTRP00000061568	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	annotation not available	0.458
CCNA1	CASP3	ENSPTRP00000070605	ENSPTRP00000054330	CCNA1 isoform 3; Belongs to the cyclin family.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	0.546
CCNA1	CCNA2	ENSPTRP00000070605	ENSPTRP00000028181	CCNA1 isoform 3; Belongs to the cyclin family.	CCNA2 isoform 1; Belongs to the cyclin family.	0.971
CCNA1	CCNB1	ENSPTRP00000070605	ENSPTRP00000029014	CCNA1 isoform 3; Belongs to the cyclin family.	CCNB1 isoform 1; Belongs to the cyclin family.	0.804
CCNA1	CCNB2	ENSPTRP00000070605	ENSPTRP00000012178	CCNA1 isoform 3; Belongs to the cyclin family.	CCNB2 isoform 1; Belongs to the cyclin family.	0.777
CCNA1	CCNB3	ENSPTRP00000070605	ENSPTRP00000065772	CCNA1 isoform 3; Belongs to the cyclin family.	CCNB3 isoform 4; Belongs to the cyclin family.	0.709
CCNA1	CCNC	ENSPTRP00000070605	ENSPTRP00000031501	CCNA1 isoform 3; Belongs to the cyclin family.	CCNC isoform 1; Belongs to the cyclin family.	0.465
CCNA1	CCNE1	ENSPTRP00000070605	ENSPTRP00000087725	CCNA1 isoform 3; Belongs to the cyclin family.	CCNE1 isoform 1; Belongs to the cyclin family.	0.840