STRINGSTRING
CSNK2A1 CSNK2A1 PKM PKM ENSPTRP00000089676 ENSPTRP00000089676 CAMK2D CAMK2D CAD CAD TSSK4 TSSK4 ROCK1 ROCK1 AKT1 AKT1 GSK3B GSK3B CIT CIT CDK5 CDK5 CAMK2A CAMK2A PKN1 PKN1 UMOD UMOD WNK1 WNK1 CDC42BPA CDC42BPA ACVR1 ACVR1 TNKS TNKS TGFBR2 TGFBR2 MAP3K12 MAP3K12 TTBK1 TTBK1 TGFBR1 TGFBR1 MARK2 MARK2 MAPK10 MAPK10 LMTK2 LMTK2 CHEK1 CHEK1 DYRK2 DYRK2 DYRK1B DYRK1B ATF2 ATF2 LOC104002294 LOC104002294 ROCK2 ROCK2 CSNK2A2 CSNK2A2 CDK5R1 CDK5R1 CDK1 CDK1 PRKDC PRKDC MAPK8 MAPK8 WNK3 WNK3 HIPK2 HIPK2 TTK TTK PRKCD PRKCD DCAF1 DCAF1 OXSR1 OXSR1 MAPK1 MAPK1 DYRK1A DYRK1A MYLK2 MYLK2 CLK1 CLK1 STK39 STK39 PRKD2 PRKD2 GSK3A GSK3A HIPK4 HIPK4 MAP3K10 MAP3K10 BCL2 BCL2 PDPK1 PDPK1 TAF1 TAF1 SBK1 SBK1 VRK1 VRK1 LMTK2-2 LMTK2-2 PRKACA PRKACA STK11 STK11 PRKCA PRKCA NLK NLK HASPIN HASPIN PRKCB PRKCB CDC42BPB CDC42BPB PRKD1 PRKD1 TBK1 TBK1 ACVR1B ACVR1B LRRK2 LRRK2 DYRK4 DYRK4 GRK2 GRK2 HIPK3 HIPK3 DYRK3 DYRK3 HIPK1 HIPK1 MTOR MTOR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CSNK2A1Casein kinase 2, alpha 1 polypeptide; Belongs to the protein kinase superfamily. (391 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
ENSPTRP00000089676annotation not available (850 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (446 aa)
CADCarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2229 aa)
TSSK4Testis specific serine kinase 4; Belongs to the protein kinase superfamily. (328 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2078 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
PKN1PKN1 isoform 2. (948 aa)
UMODUMOD isoform 1. (690 aa)
WNK1WNK1 isoform 4. (2833 aa)
CDC42BPANon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1735 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (893 aa)
TTBK1Tau tubulin kinase 1. (1321 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
MARK2Non-specific serine/threonine protein kinase. (668 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
LMTK2Lemur tyrosine kinase 2. (1503 aa)
CHEK1CHEK1 isoform 10. (485 aa)
DYRK2Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2. (601 aa)
DYRK1BDual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B. (629 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
LOC104002294LOW QUALITY PROTEIN: pyruvate kinase PKM-like. (501 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
CSNK2A2Casein kinase 2, alpha prime polypeptide; Belongs to the protein kinase superfamily. (350 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
PRKDCProtein kinase, DNA-activated, catalytic polypeptide; Belongs to the PI3/PI4-kinase family. (4128 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
WNK3WNK3 isoform 5. (1797 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
TTKTTK protein kinase. (856 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
DCAF1Vpr (HIV-1) binding protein. (1507 aa)
OXSR1Oxidative stress responsive kinase 1. (527 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
DYRK1ADual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A. (763 aa)
MYLK2MYLK2 isoform 1. (596 aa)
CLK1CDC like kinase 1. (526 aa)
STK39Serine threonine kinase 39. (545 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
GSK3AGlycogen synthase kinase 3 alpha. (483 aa)
HIPK4Homeodomain interacting protein kinase 4. (616 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (954 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
PDPK13-phosphoinositide dependent protein kinase-1. (542 aa)
TAF1Transcription initiation factor TFIID subunit. (1927 aa)
SBK1Serine/threonine-protein kinase SBK1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (419 aa)
VRK1VRK serine/threonine kinase 1; Belongs to the protein kinase superfamily. (420 aa)
LMTK2-2Lemur tyrosine kinase 2. (1503 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (307 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
HASPINHASPIN isoform 1. (798 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CDC42BPBCDC42 binding protein kinase beta (DMPK-like); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1593 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (873 aa)
TBK1TANK-binding kinase 1. (729 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (546 aa)
LRRK2Leucine-rich repeat kinase 2. (2527 aa)
DYRK4T0131183 isoform 1. (634 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
HIPK3Homeodomain interacting protein kinase 3. (1215 aa)
DYRK3Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3. (588 aa)
HIPK1HIPK1 isoform 10. (1210 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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