STRINGSTRING
TYRP1 TYRP1 ENSPTRP00000093849 ENSPTRP00000093849 CTSK CTSK FAH FAH DDC DDC SNCA SNCA BCL2 BCL2 PMEL PMEL NR4A2 NR4A2 CGA CGA RTL4 RTL4 TPH2 TPH2 MOXD1 MOXD1 OCA2 OCA2 HPRT1 HPRT1 LOC747294 LOC747294 SNCAIP SNCAIP LOC454364 LOC454364 DAO DAO TRPC1 TRPC1 LOC101058512 LOC101058512 DIO2 DIO2 DCT DCT IYD IYD LOC107971060 LOC107971060 TPH1 TPH1 DDT DDT TPO TPO LRTOMT LRTOMT AOC2-2 AOC2-2 SLC45A2 SLC45A2 CPQ CPQ DRD2 DRD2 DDTL DDTL DRD1 DRD1 DUOX1 DUOX1 GATA3 GATA3 ATP7A ATP7A ENSPTRP00000063164 ENSPTRP00000063164 GCNT4 GCNT4 MFSD12 MFSD12 GCH1 GCH1 GRIN2A GRIN2A SULT1A2 SULT1A2 HAND2 HAND2 BTBD9 BTBD9 SLC1A1 SLC1A1 FOXE1 FOXE1 MTPN MTPN SULT1A1 SULT1A1 SLC16A2 SLC16A2 CITED1 CITED1 MAOB MAOB MAOA MAOA DBH DBH TG TG CTSB CTSB GPR37 GPR37 PRKN PRKN SLC16A10 SLC16A10 SNCB SNCB RNF180 RNF180 HTR1A HTR1A SRD5A1 SRD5A1 SLC6A3 SLC6A3 EDNRA EDNRA SULT1B1 SULT1B1 COMT COMT EPAS1 EPAS1 SULT2A1 SULT2A1 SLC5A5 SLC5A5 AOC2 AOC2 PNMT PNMT MED1 MED1 CTNS CTNS CRYM CRYM HDC HDC SLC24A5 SLC24A5 DUOX2 DUOX2 KL KL PAH PAH PDE1B PDE1B TYR TYR TH TH DRD4 DRD4 CYP2E1 CYP2E1 TGFB2 TGFB2 NPR1 NPR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TYRP1TYRP1 isoform 6. (578 aa)
ENSPTRP00000093849annotation not available (285 aa)
CTSKCTSK isoform 2; Belongs to the peptidase C1 family. (343 aa)
FAHFumarylacetoacetase. (427 aa)
DDCDopa decarboxylase. (489 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
PMELPMEL isoform 1. (705 aa)
NR4A2Nuclear receptor subfamily 4, group A, member 2. (598 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (147 aa)
RTL4Retrotransposon Gag like 4. (310 aa)
TPH2Tryptophan hydroxylase 2. (490 aa)
MOXD1MOXD1 isoform 1. (613 aa)
OCA2OCA2 isoform 2. (838 aa)
HPRT1Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). (218 aa)
LOC747294D-dopachrome decarboxylase. (147 aa)
SNCAIPSNCAIP isoform 11. (1007 aa)
LOC454364Sulfotransferase; Belongs to the sulfotransferase 1 family. (295 aa)
DAOD-amino acid oxidase. (347 aa)
TRPC1TRPC1 isoform 3; Belongs to the transient receptor (TC 1.A.4) family. (795 aa)
LOC101058512LOW QUALITY PROTEIN: sulfotransferase 1 family member D1-like. (259 aa)
DIO2Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (145 aa)
DCTDopachrome tautomerase. (552 aa)
IYDIodotyrosine deiodinase. (293 aa)
LOC107971060SRD5A1 isoform 2. (141 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
DDTDDT isoform 2. (166 aa)
TPOTPO isoform 5. (847 aa)
LRTOMTTransmembrane O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function (By similarity). Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity (By similarity). (291 aa)
AOC2-2Amine oxidase. (756 aa)
SLC45A2Solute carrier family 45 member 2. (530 aa)
CPQPlasma glutamate carboxypeptidase. (471 aa)
DRD2D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (490 aa)
DDTLDDT isoform 5. (134 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
DUOX1DUOX1 isoform 1. (1551 aa)
GATA3GATA binding protein 3. (444 aa)
ATP7AATPase, Cu++ transporting, alpha polypeptide. (1500 aa)
ENSPTRP00000063164annotation not available (1061 aa)
GCNT4Glucosaminyl (N-acetyl) transferase 4. (453 aa)
MFSD12Major facilitator superfamily domain containing 12. (480 aa)
GCH1GTP cyclohydrolase 1. (250 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kineti [...] (1471 aa)
SULT1A2Sulfotransferase; Belongs to the sulfotransferase 1 family. (295 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
BTBD9BTB (POZ) domain containing 9. (612 aa)
SLC1A1Amino acid transporter. (524 aa)
FOXE1FOXE1 isoform 1. (371 aa)
MTPNMTPN isoform 1. (118 aa)
SULT1A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (295 aa)
SLC16A2Solute carrier family 16, member 2 (Monocarboxylic acid transporter 8). (537 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
MAOBAmine oxidase. (520 aa)
MAOAAmine oxidase. (527 aa)
DBHDopamine beta-hydroxylase. (617 aa)
TGTG isoform 3. (2766 aa)
CTSBCTSB isoform 10; Belongs to the peptidase C1 family. (339 aa)
GPR37G protein-coupled receptor 37. (613 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
SLC16A10SLC16A10 isoform 2. (515 aa)
SNCBBeta-synuclein; Belongs to the synuclein family. (134 aa)
RNF180Ring finger protein 180. (592 aa)
HTR1A5-hydroxytryptamine receptor 1A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second [...] (422 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (259 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SULT1B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (296 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (271 aa)
EPAS1Endothelial PAS domain protein 1. (870 aa)
SULT2A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (285 aa)
SLC5A5Solute carrier family 5 member 5; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (643 aa)
AOC2Amine oxidase copper containing 2. (756 aa)
PNMTPhenylethanolamine N-methyltransferase. (282 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
CTNSCystinosin, lysosomal cystine transporter. (400 aa)
CRYMCRYM isoform 3. (314 aa)
HDCHistidine decarboxylase. (662 aa)
SLC24A5Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (500 aa)
DUOX2DUOX2 isoform 1. (1548 aa)
KLKL isoform 1. (1012 aa)
PAHPhenylalanine hydroxylase. (452 aa)
PDE1BPhosphodiesterase. (536 aa)
TYRTYR isoform 1. (529 aa)
THTyrosine hydroxylase. (528 aa)
DRD4DRD4 isoform 1; Belongs to the G-protein coupled receptor 1 family. (415 aa)
CYP2E1Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. (531 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NPR1Guanylate cyclase. (1061 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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