(77 nodes) SCF ubiquitin ligase complex network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FBXO2	F-box protein 2. (295 aa)
	FBXO6	F-box only protein 6. (293 aa)
	FBXO42	F-box protein 42. (717 aa)
	CKS1B	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	CACYBP	Calcyclin binding protein. (228 aa)
	TMEM183A	Transmembrane protein 183A. (376 aa)
	FBH1	FBXO18 isoform 3. (1096 aa)
	CUL5	CUL5 isoform 1; Belongs to the cullin family. (780 aa)
	AMN1	Antagonist of mitotic exit network 1 homolog. (258 aa)
	FBXW8	F-box and WD repeat domain containing 8. (597 aa)
	FBXO33	F-box protein 33. (557 aa)
	FBXL16	FBXL16 isoform 1. (479 aa)
	SPSB3	SplA/ryanodine receptor domain and SOCS box containing 3. (355 aa)
	FBXL8	T0157855 isoform 2. (374 aa)
	LRRC29	Leucine-rich repeat-containing protein 29. (214 aa)
	GSE1	GSE1 isoform 7. (1321 aa)
	FBXO39	F-box protein 39. (442 aa)
	FBXL20	F-box and leucine rich repeat protein 20. (438 aa)
	FBXL12	F-box and leucine-rich repeat protein 12. (326 aa)
	FBXO27	F-box protein 27. (283 aa)
	NCCRP1	Non-specific cytotoxic cell receptor protein 1 homolog (zebrafish). (275 aa)
	DAW1	Dynein assembly factor with WD repeats 1. (415 aa)
	FBXO7	F-box protein 7. (522 aa)
	RBX1	Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
	SPSB4	SplA/ryanodine receptor domain and SOCS box containing 4. (273 aa)
	FBXO45	F-box protein 45. (286 aa)
	FBXL5	F-box and leucine-rich repeat protein 5. (691 aa)
	FBXW7	F-box and WD repeat domain containing 7. (707 aa)
	FBXL7	F-box and leucine-rich repeat protein 7. (491 aa)
	SKP2	S-phase kinase-associated protein 2 (P45). (425 aa)
	FBXO4	F-box protein 4. (387 aa)
	FBXO38	F-box protein 38. (1188 aa)
	FBXO9	F-box protein 9. (437 aa)
	FBXL4	F-box and leucine-rich repeat protein 4. (621 aa)
	FBXL18	F-box and leucine-rich repeat protein 18. (721 aa)
	FBXL13	F-box and leucine rich repeat protein 13. (735 aa)
	CUL1	CUL1 isoform 1; Belongs to the cullin family. (776 aa)
	FBXO25	F-box protein 25. (367 aa)
	FBXL6	F-box and leucine-rich repeat protein 6. (539 aa)
	CKS2	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	FBXW5	F-box and WD repeat domain containing 5. (566 aa)
	FBXO31	F-box protein 31. (543 aa)
	FBXL3	F-box and leucine-rich repeat protein 3. (428 aa)
	SPSB1	SplA/ryanodine receptor domain and SOCS box containing 1. (273 aa)
	FBXO44	F-box protein 44. (255 aa)
	USP47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa)
	CCNF	CCNF isoform 1; Belongs to the cyclin family. (786 aa)
	CUL2	CUL2 isoform 8; Belongs to the cullin family. (764 aa)
	FBXO15	FBXO15 isoform 3. (597 aa)
	FBXO32	F-box protein 32. (355 aa)
	ENSPTRP00000064916	annotation not available (631 aa)
	FBXL15	F-box and leucine-rich repeat protein 15. (300 aa)
	ENSPTRP00000071907	annotation not available (164 aa)
	ENSPTRP00000073053	annotation not available (212 aa)
	LOC100614251	F-box/WD repeat-containing protein 4 pseudogene. (342 aa)
	ENSPTRP00000075658	annotation not available (79 aa)
	FBXL19	F-box and leucine rich repeat protein 19. (694 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
	LOC744191	Calcyclin-binding protein pseudogene. (208 aa)
	FBXO48	F-box protein 48. (155 aa)
	FBXW4	F-box and WD repeat domain containing 4. (412 aa)
	FBXW11	F-box and WD repeat domain containing 11. (563 aa)
	FBXL21P	F-box and leucine-rich repeat protein 21. (432 aa)
	ENSPTRP00000078561	annotation not available (79 aa)
	DMAC2	DMAC2 isoform 4. (193 aa)
	FBXL2	F-box and leucine rich repeat protein 2. (472 aa)
	FBXL22	F-box and leucine rich repeat protein 22. (247 aa)
	ENSPTRP00000080848	annotation not available (88 aa)
	ATP5SL	DMAC2 isoform 3. (227 aa)
	FBXL17	F-box and leucine rich repeat protein 17. (715 aa)
	SPSB2	SplA/ryanodine receptor domain and SOCS box containing 2. (263 aa)
	CUL1-2	Cullin 1. (776 aa)
	CUL2-2	Cullin 2. (764 aa)
	FBXO17	F-box only protein 17 isoform X1. (278 aa)
	FBXL14	F-box and leucine-rich repeat protein 14. (418 aa)
	ENSPTRP00000091457	annotation not available (64 aa)
	ENSPTRP00000091943	annotation not available (539 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMN1	CUL1	ENSPTRP00000008227	ENSPTRP00000033967	Antagonist of mitotic exit network 1 homolog.	CUL1 isoform 1; Belongs to the cullin family.	0.449
AMN1	CUL1-2	ENSPTRP00000008227	ENSPTRP00000086353	Antagonist of mitotic exit network 1 homolog.	Cullin 1.	0.449
AMN1	ENSPTRP00000064916	ENSPTRP00000008227	ENSPTRP00000064916	Antagonist of mitotic exit network 1 homolog.	annotation not available	0.449
AMN1	ENSPTRP00000071907	ENSPTRP00000008227	ENSPTRP00000071907	Antagonist of mitotic exit network 1 homolog.	annotation not available	0.588
AMN1	RBX1	ENSPTRP00000008227	ENSPTRP00000024839	Antagonist of mitotic exit network 1 homolog.	Ring-box 1, E3 ubiquitin protein ligase.	0.571
BTRC	CCNF	ENSPTRP00000077054	ENSPTRP00000059162	Beta-transducin repeat containing E3 ubiquitin protein ligase.	CCNF isoform 1; Belongs to the cyclin family.	0.699
BTRC	CUL1	ENSPTRP00000077054	ENSPTRP00000033967	Beta-transducin repeat containing E3 ubiquitin protein ligase.	CUL1 isoform 1; Belongs to the cullin family.	0.996
BTRC	CUL1-2	ENSPTRP00000077054	ENSPTRP00000086353	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Cullin 1.	0.970
BTRC	CUL2	ENSPTRP00000077054	ENSPTRP00000063065	Beta-transducin repeat containing E3 ubiquitin protein ligase.	CUL2 isoform 8; Belongs to the cullin family.	0.456
BTRC	CUL2-2	ENSPTRP00000077054	ENSPTRP00000088790	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Cullin 2.	0.456
BTRC	ENSPTRP00000064916	ENSPTRP00000077054	ENSPTRP00000064916	Beta-transducin repeat containing E3 ubiquitin protein ligase.	annotation not available	0.970
BTRC	ENSPTRP00000071907	ENSPTRP00000077054	ENSPTRP00000071907	Beta-transducin repeat containing E3 ubiquitin protein ligase.	annotation not available	0.980
BTRC	FBXL14	ENSPTRP00000077054	ENSPTRP00000089686	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and leucine-rich repeat protein 14.	0.467
BTRC	FBXL3	ENSPTRP00000077054	ENSPTRP00000043543	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and leucine-rich repeat protein 3.	0.572
BTRC	FBXL4	ENSPTRP00000077054	ENSPTRP00000031493	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and leucine-rich repeat protein 4.	0.465
BTRC	FBXL5	ENSPTRP00000077054	ENSPTRP00000027433	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and leucine-rich repeat protein 5.	0.472
BTRC	FBXL7	ENSPTRP00000077054	ENSPTRP00000028725	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and leucine-rich repeat protein 7.	0.410
BTRC	FBXO2	ENSPTRP00000077054	ENSPTRP00000000286	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box protein 2.	0.964
BTRC	FBXO4	ENSPTRP00000077054	ENSPTRP00000028852	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box protein 4.	0.933
BTRC	FBXO6	ENSPTRP00000077054	ENSPTRP00000000287	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box only protein 6.	0.663