STRINGSTRING
RASA3 RASA3 HOMER2 HOMER2 TRPV1 TRPV1 MAPK7 MAPK7 CCR10 CCR10 SAMD14 SAMD14 AZU1 AZU1 MCOLN1 MCOLN1 PRKACA PRKACA ADGRL1 ADGRL1 TMEM38A TMEM38A CALM3 CALM3 HRC HRC TRPM4 TRPM4 FKBP1B FKBP1B HPCAL1 HPCAL1 EIF2AK3 EIF2AK3 ZAP70 ZAP70 CXCR1 CXCR1 HTR2B HTR2B NMUR1 NMUR1 ACKR3 ACKR3 PLCG1 PLCG1 ITPR2 ITPR2 ITPR1 ITPR1 CCR4 CCR4 CCR9 CCR9 CCR2 CCR2 CCR5 CCR5 KDR KDR PKD2 PKD2 NMUR2 NMUR2 TENM2 TENM2 EDN1 EDN1 ITPR3 ITPR3 LAT2 LAT2 BHLHA15 BHLHA15 FIS1 FIS1 DEFB1 DEFB1 NR5A1 NR5A1 CXCR3 CXCR3 BTK BTK DMTN DMTN GRIN1 GRIN1 TRPM5 TRPM5 CCL20 CCL20 CCRL2 CCRL2 ANK2 ANK2 TRPA1 TRPA1 NFATC2 NFATC2 CLIC2 CLIC2 PRKAA1 PRKAA1 TNNI3 TNNI3 P2RY11 P2RY11 XCR1 XCR1 ACKR2 ACKR2 MCOLN2 MCOLN2 POMC POMC PTGFR PTGFR SPHK1 SPHK1 CCR7 CCR7 ASPH ASPH CXCR6 CXCR6 CD4 CD4 PLCE1 PLCE1 GRIN2A GRIN2A CK820_G0015936 CK820_G0015936 LAT LAT CCL3 CCL3 CX3CR1 CX3CR1 SGCD SGCD LOC749464 LOC749464 AVPR1A AVPR1A ENSPTRP00000061732 ENSPTRP00000061732 CK820_G0042363 CK820_G0042363 ENSPTRP00000062183 ENSPTRP00000062183 TPCN2 TPCN2 GSTO1 GSTO1 SELE SELE PPP1R9A PPP1R9A AGTR1 AGTR1 SLC8A1 SLC8A1 GRIN2D GRIN2D RYR2 RYR2 PPP3CB PPP3CB ADGRB2 ADGRB2 NFATC1 NFATC1 RCAN3 RCAN3 CLIC2-2 CLIC2-2 NCALD NCALD SLC9A1 SLC9A1 PPP3CA PPP3CA TRPM2 TRPM2 DMPK DMPK DMD DMD BHLHA15-2 BHLHA15-2 CK820_G0010776 CK820_G0010776 TREML1 TREML1 GRIN2C GRIN2C ENSPTRP00000072507 ENSPTRP00000072507 RYR1 RYR1 BCAP31 BCAP31 RYR3 RYR3 CK820_G0030361 CK820_G0030361 ENSPTRP00000090392 ENSPTRP00000090392 PDPK1 PDPK1 NFATC4 NFATC4 CAMK2D CAMK2D TMEM38B TMEM38B RCAN1 RCAN1 NFATC3 NFATC3 ACKR4 ACKR4 FIS1-2 FIS1-2 LOC454364 LOC454364 NFAT5 NFAT5 DMD-2 DMD-2 GPR143 GPR143 SAMD3 SAMD3 CALM1 CALM1 ENSPTRP00000082718 ENSPTRP00000082718 RCAN2 RCAN2 ATP1A2 ATP1A2 MCTP2 MCTP2 ZMPSTE24 ZMPSTE24 LOC745935 LOC745935 CCR1 CCR1 IRGM IRGM MCU MCU PLCG2 PLCG2 PLN PLN CXCR2 CXCR2 MCTP1 MCTP1 PRNP PRNP TRPM8 TRPM8 SYK SYK CXCR4 CXCR4 PPP3CC PPP3CC ADA ADA PPP1R9B PPP1R9B CXCR5 CXCR5 MTOR MTOR HPCA HPCA EDN2 EDN2 MCOLN3 MCOLN3 VCAM1 VCAM1 CASQ2 CASQ2 CASQ1 CASQ1 ATP1B1 ATP1B1 SELP SELP PTPRC PTPRC NR5A2 NR5A2 CHRM3 CHRM3 PTPRJ PTPRJ PTGDR2 PTGDR2 TBC1D10C TBC1D10C GRM5 GRM5 CD3E CD3E CACNA1C CACNA1C GRIN2B GRIN2B LRRK2 LRRK2 LACRT LACRT ATP2A2 ATP2A2 TPCN1 TPCN1 KSR2 KSR2 P2RX4 P2RX4 CAMKK2 CAMKK2 TNFSF11 TNFSF11 EDNRB EDNRB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RASA3RAS p21 protein activator 3. (740 aa)
HOMER2Homer scaffold protein 2. (356 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa)
CCR10C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (362 aa)
SAMD14SAMD14 isoform 1. (445 aa)
AZU1AZU1 isoform 1. (253 aa)
MCOLN1MCOLN1 isoform 1. (601 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
ADGRL1Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family. (1477 aa)
TMEM38ATransmembrane protein 38A. (299 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
HRCHRC isoform 2. (693 aa)
TRPM4Transient receptor potential cation channel, subfamily M, member 4. (1306 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
HPCAL1Hippocalcin-like protein 1. (193 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3. (1116 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
CXCR1C-X-C chemokine receptor type 1; Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. (350 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
NMUR1Neuromedin U receptor 1; Belongs to the G-protein coupled receptor 1 family. (426 aa)
ACKR3Chemokine (C-X-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family. (362 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
ITPR1ITPR1 isoform 3. (2700 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (968 aa)
NMUR2Neuromedin U receptor 2; Belongs to the G-protein coupled receptor 1 family. (415 aa)
TENM2Teneurin transmembrane protein 2. (2774 aa)
EDN1EDN1 isoform 1. (212 aa)
ITPR3ITPR3 isoform 1. (2677 aa)
LAT2Linker for activation of T cells family member 2. (243 aa)
BHLHA15Basic helix-loop-helix family member a15. (189 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
DEFB1Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. (68 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
BTKBTK isoform 2. (693 aa)
DMTNDematin actin binding protein. (405 aa)
GRIN1Glutamate receptor, ionotropic, N-methyl D-aspartate 1. (845 aa)
TRPM5Transient receptor potential cation channel subfamily M member 5. (1172 aa)
CCL20C-C motif chemokine. (96 aa)
CCRL2C-C motif chemokine receptor like 2; Belongs to the G-protein coupled receptor 1 family. (356 aa)
ANK2ANK2 isoform 1. (3957 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1119 aa)
NFATC2NFATC2 isoform 4. (938 aa)
CLIC2Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (247 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
TNNI3TNNI3 isoform 2. (169 aa)
P2RY11Purinergic receptor P2Y11. (374 aa)
XCR1X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
ACKR2Atypical chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (384 aa)
MCOLN2MCOLN2 isoform 1. (566 aa)
POMCProopiomelanocortin. (268 aa)
PTGFRProstaglandin F receptor (FP); Belongs to the G-protein coupled receptor 1 family. (359 aa)
SPHK1Sphingosine kinase 1. (470 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
ASPHASPH isoform 1. (762 aa)
CXCR6C-X-C chemokine receptor type 6; Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1. (342 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
PLCE1Phosphoinositide phospholipase C. (2301 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kineti [...] (1471 aa)
CK820_G0015936C12orf76 isoform 1. (107 aa)
LATLinker for activation of T cells. (268 aa)
CCL3C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (92 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (387 aa)
SGCDSarcoglycan, delta (35kDa dystrophin-associated glycoprotein). (290 aa)
LOC749464Phospholipase A2. (781 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
ENSPTRP00000061732annotation not available (285 aa)
CK820_G0042363TRPM4 isoform 1. (1251 aa)
ENSPTRP00000062183annotation not available (243 aa)
TPCN2Two pore segment channel 2. (752 aa)
GSTO1Glutathione S-transferase omega 1. (241 aa)
SELESELE isoform 1. (612 aa)
PPP1R9AProtein phosphatase 1 regulatory subunit 9A. (1373 aa)
AGTR1Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system (By similarity); Belongs to the G-protein coupled receptor 1 family. (394 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
GRIN2DGRIN2D isoform 1. (1265 aa)
RYR2RYR2 isoform 1. (4941 aa)
PPP3CBSerine/threonine-protein phosphatase. (526 aa)
ADGRB2Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1585 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1. (853 aa)
RCAN3RCAN family member 3. (218 aa)
CLIC2-2Chloride intracellular channel 2. (247 aa)
NCALDNeurocalcin delta. (193 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
TRPM2TRPM2 isoform 4. (1393 aa)
DMPKDystrophia myotonica-protein kinase. (639 aa)
DMDDMD isoform 3. (3685 aa)
BHLHA15-2Basic helix-loop-helix family member a15. (189 aa)
CK820_G0010776TRPM8 isoform 5. (1112 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (311 aa)
GRIN2CGRIN2C isoform 4. (1240 aa)
ENSPTRP00000072507annotation not available (659 aa)
RYR1RYR1 isoform 3. (5037 aa)
BCAP31BCAP31 isoform 3. (246 aa)
RYR3Ryanodine receptor 3. (4873 aa)
CK820_G0030361RYR1 isoform 5. (4901 aa)
ENSPTRP00000090392annotation not available (93 aa)
PDPK13-phosphoinositide dependent protein kinase-1. (542 aa)
NFATC4Nuclear factor of activated T cells 4. (933 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (446 aa)
TMEM38BTransmembrane protein 38B. (297 aa)
RCAN1RCAN1 isoform 6. (276 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3. (1075 aa)
ACKR4Chemokine (C-C motif) receptor-like 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
FIS1-2Fission, mitochondrial 1. (152 aa)
LOC454364Sulfotransferase; Belongs to the sulfotransferase 1 family. (295 aa)
NFAT5Nuclear factor of activated T-cells 5, tonicity-responsive. (1548 aa)
DMD-2Dystrophin. (643 aa)
GPR143G protein-coupled receptor 143. (404 aa)
SAMD3Sterile alpha motif domain containing 3. (542 aa)
CALM1CALM1 isoform 3; Belongs to the calmodulin family. (150 aa)
ENSPTRP00000082718annotation not available (235 aa)
RCAN2Calcipressin-2; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity). (243 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
MCTP2Multiple C2 and transmembrane domain containing 2. (934 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
LOC745935C-C motif chemokine. (87 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
IRGMImmunity-related GTPase M. (214 aa)
MCUCoiled-coil domain containing 109A. (352 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
CXCR2C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). (360 aa)
MCTP1MCTP1 isoform 1. (997 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (253 aa)
TRPM8TRPM8 isoform 2. (1104 aa)
SYKTyrosine-protein kinase. (635 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (423 aa)
PPP3CCSerine/threonine-protein phosphatase. (521 aa)
ADAAdenosine deaminase. (412 aa)
PPP1R9BProtein phosphatase 1, regulatory (Inhibitor) subunit 9B. (817 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
HPCAHPCA isoform 3. (193 aa)
EDN2EDN2 isoform 1. (178 aa)
MCOLN3MCOLN3 isoform 1. (553 aa)
VCAM1Vascular cell adhesion molecule 1. (650 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (396 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). (303 aa)
SELPSELP isoform 2. (830 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1306 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (541 aa)
CHRM3Muscarinic acetylcholine receptor M3; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). (590 aa)
PTPRJPTPRJ isoform 4. (1312 aa)
PTGDR2Prostaglandin D2 receptor 2; Belongs to the G-protein coupled receptor 1 family. (396 aa)
TBC1D10CTBC1 domain family member 10C. (446 aa)
GRM5Glutamate metabotropic receptor 5. (1210 aa)
CD3ECD3E isoform 2. (207 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
LRRK2Leucine-rich repeat kinase 2. (2527 aa)
LACRTLACRT isoform 3. (137 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
TPCN1TPCN1 isoform 2. (888 aa)
KSR2Kinase suppressor of ras 2. (950 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (346 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2, beta. (588 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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