STRINGSTRING
PLIN5 PLIN5 APOE APOE CDS2 CDS2 ENPP1 ENPP1 PLIN2 PLIN2 ACVR1C ACVR1C FITM2 FITM2 DGAT1 DGAT1 CAV1 CAV1 ANGPTL3 ANGPTL3 PNPLA2 PNPLA2 DGAT2 DGAT2 B4GALNT1 B4GALNT1 CRY1 CRY1 FITM1 FITM1 RNF213 RNF213 CIDEA CIDEA PLIN3 PLIN3 FFAR2 FFAR2 PLA2G4C PLA2G4C AUP1 AUP1 IL1B IL1B HEXB HEXB STAT5B STAT5B CELF6-2 CELF6-2 SMIM22 SMIM22 TNF TNF SQLE SQLE ENSPTRP00000062299 ENSPTRP00000062299 NRIP1 NRIP1 ZFYVE1 ZFYVE1 STARD4 STARD4 SOAT1 SOAT1 CRY2 CRY2 LDAH LDAH CD36 CD36 BSCL2 BSCL2 GM2A GM2A CDS1 CDS1 TMEM159 TMEM159
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLIN5Perilipin-5 isoform X1. (287 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
CDS2Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (445 aa)
ENPP1ENPP1 isoform 1. (925 aa)
PLIN2Perilipin; Belongs to the perilipin family. (445 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
FITM2Fat storage-inducing transmembrane protein 2. (262 aa)
DGAT1O-acyltransferase. (488 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
PNPLA2Patatin like phospholipase domain containing 2. (495 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (388 aa)
B4GALNT1Beta-1,4 N-acetylgalactosaminyltransferase. (533 aa)
CRY1Cryptochrome circadian regulator 1. (586 aa)
FITM1Fat storage-inducing transmembrane protein 1. (292 aa)
RNF213RNF213 isoform 1. (5256 aa)
CIDEACIDEA isoform 1. (253 aa)
PLIN3Perilipin; Belongs to the perilipin family. (468 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (330 aa)
PLA2G4CPhospholipase A2 group IVC. (541 aa)
AUP1AUP1 lipid droplet regulating VLDL assembly factor. (410 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
HEXBBeta-hexosaminidase. (557 aa)
STAT5BSignal transducer and activator of transcription. (772 aa)
CELF6-2CUGBP Elav-like family member 6 isoform X1. (538 aa)
SMIM22Small integral membrane protein 22. (135 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
SQLESqualene epoxidase. (574 aa)
ENSPTRP00000062299annotation not available (99 aa)
NRIP1Nuclear receptor interacting protein 1. (1158 aa)
ZFYVE1Zinc finger FYVE-type containing 1. (789 aa)
STARD4StAR-related lipid transfer (START) domain containing 4. (205 aa)
SOAT1O-acyltransferase. (550 aa)
CRY2Cryptochrome circadian regulator 2. (614 aa)
LDAHLipid droplet associated hydrolase. (370 aa)
CD36CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family. (472 aa)
BSCL2Berardinelli-Seip congenital lipodystrophy 2 (Seipin). (464 aa)
GM2AGM2 ganglioside activator. (194 aa)
CDS1Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (461 aa)
TMEM159Transmembrane protein 159. (185 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: medium (44%) [HD]