| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANGPTL3 | APOE | ENSPTRP00000001403 | ENSPTRP00000054411 | Angiopoietin like 3. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.468 |
| APOE | ANGPTL3 | ENSPTRP00000054411 | ENSPTRP00000001403 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | Angiopoietin like 3. | 0.468 |
| APOE | CD36 | ENSPTRP00000054411 | ENSPTRP00000074671 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family. | 0.616 |
| APOE | DGAT1 | ENSPTRP00000054411 | ENSPTRP00000035395 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | O-acyltransferase. | 0.444 |
| APOE | IL1B | ENSPTRP00000054411 | ENSPTRP00000021191 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.678 |
| APOE | SOAT1 | ENSPTRP00000054411 | ENSPTRP00000078753 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | O-acyltransferase. | 0.430 |
| APOE | TNF | ENSPTRP00000054411 | ENSPTRP00000069905 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.654 |
| AUP1 | DGAT2 | ENSPTRP00000020760 | ENSPTRP00000007025 | AUP1 lipid droplet regulating VLDL assembly factor. | Diacylglycerol O-acyltransferase 2. | 0.448 |
| BSCL2 | DGAT1 | ENSPTRP00000085384 | ENSPTRP00000035395 | Berardinelli-Seip congenital lipodystrophy 2 (Seipin). | O-acyltransferase. | 0.416 |
| BSCL2 | DGAT2 | ENSPTRP00000085384 | ENSPTRP00000007025 | Berardinelli-Seip congenital lipodystrophy 2 (Seipin). | Diacylglycerol O-acyltransferase 2. | 0.438 |
| BSCL2 | FITM2 | ENSPTRP00000085384 | ENSPTRP00000023218 | Berardinelli-Seip congenital lipodystrophy 2 (Seipin). | Fat storage-inducing transmembrane protein 2. | 0.543 |
| BSCL2 | TMEM159 | ENSPTRP00000085384 | ENSPTRP00000059928 | Berardinelli-Seip congenital lipodystrophy 2 (Seipin). | Transmembrane protein 159. | 0.654 |
| CD36 | APOE | ENSPTRP00000074671 | ENSPTRP00000054411 | CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.616 |
| CD36 | DGAT1 | ENSPTRP00000074671 | ENSPTRP00000035395 | CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family. | O-acyltransferase. | 0.669 |
| CD36 | DGAT2 | ENSPTRP00000074671 | ENSPTRP00000007025 | CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family. | Diacylglycerol O-acyltransferase 2. | 0.506 |
| CD36 | IL1B | ENSPTRP00000074671 | ENSPTRP00000021191 | CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.582 |
| CD36 | PLIN2 | ENSPTRP00000074671 | ENSPTRP00000035582 | CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family. | Perilipin; Belongs to the perilipin family. | 0.491 |
| CD36 | PNPLA2 | ENSPTRP00000074671 | ENSPTRP00000005535 | CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family. | Patatin like phospholipase domain containing 2. | 0.560 |
| CD36 | TNF | ENSPTRP00000074671 | ENSPTRP00000069905 | CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.592 |
| CDS1 | CDS2 | ENSPTRP00000060905 | ENSPTRP00000052392 | Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. | Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. | 0.944 |