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ITGAV ITGAV IFNGR1 IFNGR1 XCR1 XCR1 ACKR2 ACKR2 SPINT3 SPINT3 CCR7 CCR7 VASN VASN IFNAR2 IFNAR2 CXCR6 CXCR6 CD4 CD4 A2M A2M SCUBE3 SCUBE3 CX3CR1 CX3CR1 COMP COMP LEPR LEPR TRIM16 TRIM16 IL20RA IL20RA ENSPTRP00000062048 ENSPTRP00000062048 IFNAR2-2 IFNAR2-2 ENSPTRP00000064416 ENSPTRP00000064416 IL6ST IL6ST CRLF2 CRLF2 TNFRSF1A TNFRSF1A LOC459462 LOC459462 TGFBR3 TGFBR3 THBS1 THBS1 SOSTDC1 SOSTDC1 PLP2 PLP2 LRRC32 LRRC32 NBL1 NBL1 CHRDL2 CHRDL2 IL23R IL23R ENSPTRP00000070902 ENSPTRP00000070902 WFIKKN1 WFIKKN1 ENSPTRP00000071805 ENSPTRP00000071805 IL27RA IL27RA CXCR5 CXCR5 TGFBR1 TGFBR1 GHR GHR CXCR4 CXCR4 CD36 CD36 IL1R1 IL1R1 IL36RN IL36RN CD109 CD109 TGFBR2 TGFBR2 ACVR1 ACVR1 CXCR2 CXCR2 ENSPTRP00000077294 ENSPTRP00000077294 CCR1 CCR1 CK820_G0056611 CK820_G0056611 PARK7 PARK7 LIFR LIFR IL13RA2-2 IL13RA2-2 ENSPTRP00000079019 ENSPTRP00000079019 IL1RN IL1RN CSF1R CSF1R CHRDL1 CHRDL1 ENSPTRP00000083435 ENSPTRP00000083435 GBP1 GBP1 GDF5 GDF5 IFNAR1 IFNAR1 IL2RB IL2RB IL5RA IL5RA CCR4 CCR4 CCR9 CCR9 CCR2 CCR2 CCR5 CCR5 IL20RB IL20RB IL12A IL12A NRROS NRROS KIT KIT BMPR1B BMPR1B PRLR PRLR OSMR OSMR IL31RA IL31RA IL10RA IL10RA ENSPTRP00000085116 ENSPTRP00000085116 WFIKKN2 WFIKKN2 HJV HJV CHRD CHRD ACKR4 ACKR4 KCP KCP SOSTDC1-2 SOSTDC1-2 TGFB3 TGFB3 IL12B IL12B ENSPTRP00000012851 ENSPTRP00000012851 TRIM16-2 TRIM16-2 TCAP TCAP CCR10 CCR10 IL17F IL17F BMPER BMPER SOST SOST NOG NOG TMC8 TMC8 TWSG1 TWSG1 ELANE ELANE EBI3 EBI3 ZFP36 ZFP36 LTBP4 LTBP4 NLRP7 NLRP7 IL1R2 IL1R2 IL18R1 IL18R1 ACVRL1 ACVRL1 NRP2 NRP2 CXCR1 CXCR1 ACKR3 ACKR3 TNFRSF11A TNFRSF11A LOC466759 LOC466759 GREM2 GREM2 PXDN PXDN TNFRSF9 TNFRSF9 NLRP7-2 NLRP7-2 IL22RA2 IL22RA2 CER1 CER1 CNTFR CNTFR ENG ENG TRAF2 TRAF2 CXCR3 CXCR3 IL13RA2 IL13RA2 IL13RA1 IL13RA1 CCR3 CCR3 CSF2RA CSF2RA TNFRSF14 TNFRSF14 TNFRSF1B TNFRSF1B PDPN PDPN IL22RA1 IL22RA1 CSF3R CSF3R IL12RB2 IL12RB2 HAX1 HAX1 IL6R IL6R ACKR1 ACKR1 KLHL20 KLHL20 IL2RA IL2RA UCMA UCMA NRP1 NRP1 BMPR1A BMPR1A LTBP3 LTBP3 IL18BP IL18BP FZD4 FZD4 COPS5 COPS5 CCRL2 CCRL2 IL12RB1 IL12RB1 LTBP1 LTBP1 HYAL2 HYAL2 IL2RG IL2RG TSKU TSKU CD74 CD74 BMPR2 BMPR2 CRLF1 CRLF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGAVIntegrin, alpha V (Vitronectin receptor, alpha polypeptide, antigen CD51); Belongs to the integrin alpha chain family. (1048 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
XCR1X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
ACKR2Atypical chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (384 aa)
SPINT3Serine peptidase inhibitor, Kunitz type 3. (89 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
VASNVASN isoform 1. (673 aa)
IFNAR2Interferon alpha/beta receptor 2 isoform X4. (519 aa)
CXCR6C-X-C chemokine receptor type 6; Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1. (342 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
A2MAlpha-2-macroglobulin. (1474 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (993 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (387 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
LEPRLeptin receptor. (1165 aa)
TRIM16T0195358 isoform 1. (564 aa)
IL20RAInterleukin 20 receptor subunit alpha. (553 aa)
ENSPTRP00000062048annotation not available (257 aa)
IFNAR2-2Interferon alpha and beta receptor subunit 2. (519 aa)
ENSPTRP00000064416annotation not available (502 aa)
IL6STInterleukin 6 signal transducer (Gp130, oncostatin M receptor). (918 aa)
CRLF2CRLF2 isoform 1. (372 aa)
TNFRSF1ATumor necrosis factor receptor superfamily, member 1A. (455 aa)
LOC459462Uncharacterized protein. (328 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
THBS1Thrombospondin 1. (1173 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
PLP2Proteolipid protein 2 (Colonic epithelium-enriched). (156 aa)
LRRC32Leucine rich repeat containing 32. (662 aa)
NBL1Neuroblastoma suppressor of tumorigenicity 1. (216 aa)
CHRDL2CHRDL2 isoform 2. (452 aa)
IL23RIL23R isoform 1. (629 aa)
ENSPTRP00000070902annotation not available (168 aa)
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (548 aa)
ENSPTRP00000071805annotation not available (188 aa)
IL27RAInterleukin 27 receptor subunit alpha. (554 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
GHRGrowth hormone receptor. (645 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (423 aa)
CD36CD36 molecule (Thrombospondin receptor); Belongs to the CD36 family. (472 aa)
IL1R1Interleukin 1 receptor, type I. (569 aa)
IL36RNInterleukin-1. (155 aa)
CD109CD109 isoform 3. (1446 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
CXCR2C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). (360 aa)
ENSPTRP00000077294annotation not available (558 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CK820_G0056611IL3RA isoform 1. (278 aa)
PARK7PARK7 isoform 1. (189 aa)
LIFRLeukemia inhibitory factor receptor alpha. (1097 aa)
IL13RA2-2Interleukin 13 receptor subunit alpha 2. (380 aa)
ENSPTRP00000079019annotation not available (165 aa)
IL1RNInterleukin-1. (180 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
CHRDL1CHRDL1 isoform 3. (458 aa)
ENSPTRP00000083435annotation not available (291 aa)
GBP1Guanylate binding protein 1. (594 aa)
GDF5GDF5 isoform 1. (501 aa)
IFNAR1Interferon (Alpha, beta and omega) receptor 1. (558 aa)
IL2RBInterleukin-2 receptor subunit beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). (551 aa)
IL5RAInterleukin 5 receptor subunit alpha. (423 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
IL20RBInterleukin 20 receptor subunit beta. (311 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (622 aa)
OSMROncostatin M receptor. (979 aa)
IL31RAInterleukin 31 receptor A. (764 aa)
IL10RAInterleukin 10 receptor subunit alpha. (578 aa)
ENSPTRP00000085116annotation not available (227 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (576 aa)
HJVHFE2 isoform 1. (426 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (955 aa)
ACKR4Chemokine (C-C motif) receptor-like 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
KCPKielin cysteine rich BMP regulator. (1628 aa)
SOSTDC1-2Sclerostin domain containing 1. (206 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
ENSPTRP00000012851annotation not available (343 aa)
TRIM16-2Tripartite motif containing 16. (560 aa)
TCAPTCAP isoform 1. (167 aa)
CCR10C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (362 aa)
IL17FIL17F isoform 1. (199 aa)
BMPERBMP binding endothelial regulator. (685 aa)
SOSTSOST isoform 1. (213 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TMC8Transmembrane channel-like protein. (726 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
ELANEElastase, neutrophil expressed. (267 aa)
EBI3Epstein-Barr virus induced 3. (229 aa)
ZFP36Zinc finger protein 36, C3H type, homolog. (332 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1622 aa)
NLRP7NLRP7 isoform 2. (1037 aa)
IL1R2Interleukin 1 receptor type 2. (398 aa)
IL18R1Uncharacterized protein. (440 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
CXCR1C-X-C chemokine receptor type 1; Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. (350 aa)
ACKR3Chemokine (C-X-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family. (362 aa)
TNFRSF11ATNF receptor superfamily member 11a. (617 aa)
LOC466759COP9 signalosome complex subunit 5 pseudogene. (334 aa)
GREM2Gremlin. (168 aa)
PXDNPeroxidasin homolog. (1479 aa)
TNFRSF9TNF receptor superfamily member 9. (255 aa)
NLRP7-2Uncharacterized protein. (1097 aa)
IL22RA2Interleukin 22 receptor subunit alpha 2. (263 aa)
CER1CER1 isoform 1. (267 aa)
CNTFRCNTFR isoform 1. (372 aa)
ENGENG isoform 1. (658 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (393 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (429 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
CSF2RACSF2RA isoform 11. (215 aa)
TNFRSF14Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator). (283 aa)
TNFRSF1BTumor necrosis factor receptor superfamily, member 1B. (461 aa)
PDPNPDPN isoform 3. (238 aa)
IL22RA1Interleukin 22 receptor subunit alpha 1. (574 aa)
CSF3RCSF3R isoform 3. (836 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (862 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
IL6RInterleukin 6 receptor. (442 aa)
ACKR1Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...] (336 aa)
KLHL20Kelch like family member 20. (609 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (272 aa)
UCMAUCMA isoform 1. (138 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1297 aa)
IL18BPInterleukin 18 binding protein. (194 aa)
FZD4FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
COPS5COP9 constitutive photomorphogenic homolog subunit 5. (334 aa)
CCRL2C-C motif chemokine receptor like 2; Belongs to the G-protein coupled receptor 1 family. (356 aa)
IL12RB1IL12RB1 isoform 1. (662 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1719 aa)
HYAL2Hyaluronidase. (473 aa)
IL2RGIL2RG isoform 1. (369 aa)
TSKUTsukushi, small leucine rich proteoglycan. (353 aa)
CD74CD74 isoform 5. (296 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
CRLF1Cytokine receptor like factor 1. (459 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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