18 items (Pan troglodytes) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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Your Input:
	ASCL1	Achaete-scute family bHLH transcription factor 1. (232 aa)
	TULP3	TULP3 isoform 3; Belongs to the TUB family. (501 aa)
	CHRD	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (955 aa)
	SMO-2	Smoothened, frizzled class receptor. (786 aa)
	LHX3	LHX3 isoform 2. (402 aa)
	SOX1	SOX1 isoform 1. (391 aa)
	GLI2	GLI family zinc finger 2. (1587 aa)
	DMRT3	Doublesex and mab-3 related transcription factor 3. (472 aa)
	SMO	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	GLI3	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
	INTU	Inturned planar cell polarity effector homolog. (911 aa)
	NKX2-2	NKX2-2 isoform 1. (273 aa)
	FOXN4	FOXN4 isoform 2. (517 aa)
	DBX1	Developing brain homeobox 1. (345 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
	SUFU	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	RFX4	Regulatory factor X4. (744 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL1	FOXN4	ENSPTRP00000077846	ENSPTRP00000009196	Achaete-scute family bHLH transcription factor 1.	FOXN4 isoform 2.	0.420
ASCL1	LHX3	ENSPTRP00000077846	ENSPTRP00000063429	Achaete-scute family bHLH transcription factor 1.	LHX3 isoform 2.	0.400
ASCL1	NKX2-2	ENSPTRP00000077846	ENSPTRP00000022825	Achaete-scute family bHLH transcription factor 1.	NKX2-2 isoform 1.	0.685
ASCL1	SHH	ENSPTRP00000077846	ENSPTRP00000075730	Achaete-scute family bHLH transcription factor 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.538
ASCL1	SOX1	ENSPTRP00000077846	ENSPTRP00000061108	Achaete-scute family bHLH transcription factor 1.	SOX1 isoform 1.	0.465
CHRD	SHH	ENSPTRP00000086110	ENSPTRP00000075730	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.409
DBX1	SHH	ENSPTRP00000068188	ENSPTRP00000075730	Developing brain homeobox 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.459
FOXN4	ASCL1	ENSPTRP00000009196	ENSPTRP00000077846	FOXN4 isoform 2.	Achaete-scute family bHLH transcription factor 1.	0.420
GLI2	GLI3	ENSPTRP00000040313	ENSPTRP00000032656	GLI family zinc finger 2.	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	0.987
GLI2	SHH	ENSPTRP00000040313	ENSPTRP00000075730	GLI family zinc finger 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.846
GLI2	SMO	ENSPTRP00000040313	ENSPTRP00000033707	GLI family zinc finger 2.	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.884
GLI2	SMO-2	ENSPTRP00000040313	ENSPTRP00000067533	GLI family zinc finger 2.	Smoothened, frizzled class receptor.	0.869
GLI2	SUFU	ENSPTRP00000040313	ENSPTRP00000073892	GLI family zinc finger 2.	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	0.996
GLI2	TULP3	ENSPTRP00000040313	ENSPTRP00000067647	GLI family zinc finger 2.	TULP3 isoform 3; Belongs to the TUB family.	0.499
GLI3	GLI2	ENSPTRP00000032656	ENSPTRP00000040313	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	GLI family zinc finger 2.	0.987
GLI3	INTU	ENSPTRP00000032656	ENSPTRP00000028215	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	Inturned planar cell polarity effector homolog.	0.424
GLI3	SHH	ENSPTRP00000032656	ENSPTRP00000075730	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.862
GLI3	SMO	ENSPTRP00000032656	ENSPTRP00000033707	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.842
GLI3	SMO-2	ENSPTRP00000032656	ENSPTRP00000067533	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	Smoothened, frizzled class receptor.	0.789
GLI3	SUFU	ENSPTRP00000032656	ENSPTRP00000073892	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	0.997