STRINGSTRING
DBX1 DBX1 PAX6 PAX6 LHX3 LHX3 SOX1 SOX1 RELN RELN TCTN1 TCTN1 LHX1 LHX1 GATA2 GATA2 DAB1 DAB1 SOX4 SOX4 LBX1 LBX1 VLDLR VLDLR PHOX2A PHOX2A MNX1 MNX1 MDGA2 MDGA2 GLI2 GLI2 ZC4H2 ZC4H2 DMRT3 DMRT3 GBX1 GBX1 GLI3 GLI3 TBX20 TBX20 OLIG3 OLIG3 ABT1 ABT1 ISL1 ISL1 NKX2-2 NKX2-2 HOXD10 HOXD10 DCTN1 DCTN1 ISL2 ISL2 FOXN4 FOXN4 HOXC10 HOXC10 SCYL1 SCYL1 LHX4 LHX4 LMO4 LMO4 LRP8 LRP8 SCYL3 SCYL3 PTCH1 PTCH1 VSTM5 VSTM5 ENSPTRP00000079007 ENSPTRP00000079007 ASCL1 ASCL1 DYNC2H1 DYNC2H1 SHH SHH CLN8 CLN8 SUFU SUFU IFT172 IFT172 DLL4 DLL4 OLIG2 OLIG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DBX1Developing brain homeobox 1. (345 aa)
PAX6PAX6 isoform 13. (436 aa)
LHX3LHX3 isoform 2. (402 aa)
SOX1SOX1 isoform 1. (391 aa)
RELNRELN isoform 3. (3460 aa)
TCTN1Tectonic family member 1. (592 aa)
LHX1LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
GATA2GATA binding protein 2. (480 aa)
DAB1DAB adaptor protein 1. (588 aa)
SOX4Transcription factor SOX. (474 aa)
LBX1Ladybird homeobox 1. (281 aa)
VLDLRVery low density lipoprotein receptor. (874 aa)
PHOX2APaired like homeobox 2A. (284 aa)
MNX1Motor neuron and pancreas homeobox 1. (398 aa)
MDGA2MAM domain containing glycosylphosphatidylinositol anchor 2. (1025 aa)
GLI2GLI family zinc finger 2. (1587 aa)
ZC4H2Zinc finger, C4H2 domain containing. (224 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (472 aa)
GBX1Gastrulation brain homeobox 1. (363 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
TBX20T-box transcription factor 20. (447 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
ABT1Activator of basal transcription 1. (272 aa)
ISL1ISL LIM homeobox 1. (349 aa)
NKX2-2NKX2-2 isoform 1. (273 aa)
HOXD10Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (410 aa)
DCTN1T0125321 isoform 1. (1278 aa)
ISL2ISL LIM homeobox 2. (359 aa)
FOXN4FOXN4 isoform 2. (517 aa)
HOXC10Homeobox protein Hox-C10. (342 aa)
SCYL1SCY1 like pseudokinase 1. (808 aa)
LHX4LHX4 isoform 1. (390 aa)
LMO4LIM domain only 4. (165 aa)
LRP8LDL receptor related protein 8. (960 aa)
SCYL3SCY1 like pseudokinase 3. (742 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
VSTM5V-set and transmembrane domain containing 5. (200 aa)
ENSPTRP00000079007annotation not available (323 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
DYNC2H1DYNC2H1 isoform 4. (4314 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
CLN8Ceroid-lipofuscinosis neuronal protein 8. (286 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
IFT172Intraflagellar transport 172 homolog. (1767 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
OLIG2OLIG2 isoform 1. (323 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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