39 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	KDM2B	Lysine (K)-specific demethylase 2B. (1336 aa)
	EN1	Homeobox protein engrailed-like. (396 aa)
	ATP6AP2	ATPase, H+ transporting, lysosomal accessory protein 2. (350 aa)
	SOX17	SOX17 isoform 1. (416 aa)
	SMO	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	GLI3	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
	WDR19	WD repeat domain 19. (1342 aa)
	ARL13B	ADP ribosylation factor like GTPase 13B. (428 aa)
	GBX2	Gastrulation brain homeobox 2. (348 aa)
	FKBP8	Peptidylprolyl isomerase. (413 aa)
	TMEM107	Transmembrane protein 107. (146 aa)
	RPGRIP1L	RPGRIP1L isoform 4. (1269 aa)
	IFT140	Intraflagellar transport 140 homolog. (1471 aa)
	GSC	Homeobox protein goosecoid; Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity); Belongs to the paired homeobox family. Bicoid subfamily. (257 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	TBC1D32	TBC1D32 isoform 4. (1298 aa)
	PTCH1	PTCH1 isoform 8. (1428 aa)
	ENSPTRP00000087502	annotation not available (347 aa)
	ENSPTRP00000086171	annotation not available (421 aa)
	ENSPTRP00000085013	annotation not available (166 aa)
	SSBP3	Single stranded DNA binding protein 3. (388 aa)
	LOC737148	Single-stranded DNA-binding protein 3 pseudogene. (331 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	SUFU	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
	RNF220	Ring finger protein 220. (566 aa)
	DZIP1L	DAZ interacting zinc finger protein 1 like. (767 aa)
	TULP3	TULP3 isoform 3; Belongs to the TUB family. (501 aa)
	SMO-2	Smoothened, frizzled class receptor. (786 aa)
	TMEM107-2	Transmembrane protein 107. (140 aa)
	PAX6	PAX6 isoform 13. (436 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	FOXA1	FOXA1 isoform 1. (471 aa)
	ENSPTRP00000061866	annotation not available (267 aa)
	TCTN1	Tectonic family member 1. (592 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARL13B	GLI3	ENSPTRP00000026120	ENSPTRP00000032656	ADP ribosylation factor like GTPase 13B.	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	0.463
ARL13B	IFT140	ENSPTRP00000026120	ENSPTRP00000012987	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 140 homolog.	0.465
ARL13B	PTCH1	ENSPTRP00000026120	ENSPTRP00000087586	ADP ribosylation factor like GTPase 13B.	PTCH1 isoform 8.	0.459
ARL13B	RPGRIP1L	ENSPTRP00000026120	ENSPTRP00000013851	ADP ribosylation factor like GTPase 13B.	RPGRIP1L isoform 4.	0.685
ARL13B	SHH	ENSPTRP00000026120	ENSPTRP00000075730	ADP ribosylation factor like GTPase 13B.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.612
ARL13B	SMO	ENSPTRP00000026120	ENSPTRP00000033707	ADP ribosylation factor like GTPase 13B.	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.467
ARL13B	SMO-2	ENSPTRP00000026120	ENSPTRP00000067533	ADP ribosylation factor like GTPase 13B.	Smoothened, frizzled class receptor.	0.467
ARL13B	TCTN1	ENSPTRP00000026120	ENSPTRP00000056716	ADP ribosylation factor like GTPase 13B.	Tectonic family member 1.	0.543
ARL13B	TULP3	ENSPTRP00000026120	ENSPTRP00000067647	ADP ribosylation factor like GTPase 13B.	TULP3 isoform 3; Belongs to the TUB family.	0.477
BMP4	FGF8	ENSPTRP00000010780	ENSPTRP00000075677	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.724
BMP4	PAX6	ENSPTRP00000010780	ENSPTRP00000065705	Bone morphogenetic protein 4.	PAX6 isoform 13.	0.475
BMP4	PTCH1	ENSPTRP00000010780	ENSPTRP00000087586	Bone morphogenetic protein 4.	PTCH1 isoform 8.	0.454
BMP4	SHH	ENSPTRP00000010780	ENSPTRP00000075730	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.720
BMP4	SOX17	ENSPTRP00000010780	ENSPTRP00000034688	Bone morphogenetic protein 4.	SOX17 isoform 1.	0.523
BMP4	WNT3A	ENSPTRP00000010780	ENSPTRP00000051074	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.708
BMP4-2	FGF8	ENSPTRP00000080656	ENSPTRP00000075677	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.724
BMP4-2	PAX6	ENSPTRP00000080656	ENSPTRP00000065705	Bone morphogenetic protein 4.	PAX6 isoform 13.	0.475
BMP4-2	PTCH1	ENSPTRP00000080656	ENSPTRP00000087586	Bone morphogenetic protein 4.	PTCH1 isoform 8.	0.454
BMP4-2	SHH	ENSPTRP00000080656	ENSPTRP00000075730	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.720
BMP4-2	SOX17	ENSPTRP00000080656	ENSPTRP00000034688	Bone morphogenetic protein 4.	SOX17 isoform 1.	0.523