STRINGSTRING
CRKL CRKL GNPAT GNPAT NCSTN NCSTN ENSPTRP00000092702 ENSPTRP00000092702 ENSPTRP00000092364 ENSPTRP00000092364 TRNP1 TRNP1 EZH2-2 EZH2-2 ENSPTRP00000089450 ENSPTRP00000089450 NEUROD2 NEUROD2 NAV2 NAV2 OPHN1 OPHN1 KLHL1 KLHL1 CDK5R2 CDK5R2 PTBP2 PTBP2 ZNF365 ZNF365 RORA RORA SDF4 SDF4 ENSPTRP00000086358 ENSPTRP00000086358 B4GALT2 B4GALT2 ENSPTRP00000085189 ENSPTRP00000085189 MDK MDK CRK CRK PTF1A PTF1A GART-2 GART-2 GRID2 GRID2 SSTR2 SSTR2 MECP2 MECP2 FAM205A FAM205A ENSPTRP00000081136 ENSPTRP00000081136 SEZ6L2 SEZ6L2 CDK5 CDK5 ENSPTRP00000080117 ENSPTRP00000080117 LOC107974864 LOC107974864 ARCN1 ARCN1 GLI1 GLI1 ENSPTRP00000078003 ENSPTRP00000078003 EZH2 EZH2 ENSPTRP00000077211 ENSPTRP00000077211 ENSPTRP00000077189 ENSPTRP00000077189 UQCRQ UQCRQ CNTN1 CNTN1 ENSPTRP00000074763 ENSPTRP00000074763 PTPN11-2 PTPN11-2 NRXN1 NRXN1 ABL1 ABL1 ENSPTRP00000070863 ENSPTRP00000070863 ENSPTRP00000070307 ENSPTRP00000070307 SCN5A SCN5A SSTR3 SSTR3 AGTPBP1 AGTPBP1 SSTR1 SSTR1 WHRN WHRN SMO-2 SMO-2 ENSPTRP00000067174 ENSPTRP00000067174 MYO16 MYO16 KLHL5 KLHL5 FOXC1 FOXC1 WNT7A WNT7A ATP7A ATP7A CK820_G0054728 CK820_G0054728 LPAR1 LPAR1 LOC100609513 LOC100609513 CLP1 CLP1 CK820_G0012168 CK820_G0012168 PTPN11 PTPN11 LHX1 LHX1 AARS1 AARS1 CDK5R1 CDK5R1 DAB1 DAB1 PROX1 PROX1 EN1 EN1 CEND1 CEND1 GART GART MTPN MTPN COQ8B COQ8B GDF10 GDF10 ATIC ATIC SPTBN2 SPTBN2 NLGN4X NLGN4X GLI2 GLI2 LDB1 LDB1 KLHL4 KLHL4 SMO SMO OGDH OGDH DLL1 DLL1 DIXDC1 DIXDC1 PDSS2 PDSS2 AIF1 AIF1 SLC25A46 SLC25A46 CPLANE1 CPLANE1 HNRNPD HNRNPD TTLL1 TTLL1 CBS CBS NANOS1 NANOS1 ATRN ATRN GBX2 GBX2 SERPINE2 SERPINE2 TTC21B TTC21B SEMA4C SEMA4C PTPRS PTPRS NAGLU NAGLU HAP1 HAP1 SEZ6 SEZ6 TP53 TP53 RPGRIP1L RPGRIP1L CBLN1 CBLN1 ABAT ABAT IGF1R IGF1R HERC1 HERC1 TTBK2 TTBK2 CKB CKB PSEN1 PSEN1 LHX5 LHX5 FAIM2 FAIM2 WNT1 WNT1 CD3E CD3E FZD4 FZD4 KCNC1 KCNC1 KNDC1 KNDC1 KIF14 KIF14 LMX1A LMX1A HSPA5 HSPA5 RERE RERE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
GNPATDihydroxyacetone phosphate acyltransferase. (691 aa)
NCSTNNCSTN isoform 1. (721 aa)
ENSPTRP00000092702annotation not available (482 aa)
ENSPTRP00000092364annotation not available (574 aa)
TRNP1TMF1-regulated nuclear protein 1. (227 aa)
EZH2-2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
ENSPTRP00000089450annotation not available (303 aa)
NEUROD2Neurogenic differentiation factor. (382 aa)
NAV2Neuron navigator 2. (2488 aa)
OPHN1Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre- synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). (810 aa)
KLHL1Kelch like family member 1. (748 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (367 aa)
PTBP2Polypyrimidine tract binding protein 2. (543 aa)
ZNF365Zinc finger protein 365. (407 aa)
RORARAR-related orphan receptor A. (555 aa)
SDF4Stromal cell derived factor 4. (407 aa)
ENSPTRP00000086358annotation not available (72 aa)
B4GALT2B4GALT2 isoform 6. (398 aa)
ENSPTRP00000085189annotation not available (1896 aa)
MDKMidkine (Neurite growth-promoting factor 2). (143 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
PTF1APancreas associated transcription factor 1a. (328 aa)
GART-2annotation not available (1010 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (1007 aa)
SSTR2Somatostatin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
FAM205AFAM205A isoform 1. (1298 aa)
ENSPTRP00000081136LOW QUALITY PROTEIN: uncharacterized protein LOC100614654. (148 aa)
SEZ6L2Seizure related 6 homolog-like 2. (923 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
ENSPTRP00000080117annotation not available (567 aa)
LOC107974864Cytochrome b-c1 complex subunit 8. (82 aa)
ARCN1Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (552 aa)
GLI1GLI family zinc finger 1. (1106 aa)
ENSPTRP00000078003annotation not available (847 aa)
EZH2Enhancer of zeste homolog 2. (754 aa)
ENSPTRP00000077211annotation not available (269 aa)
ENSPTRP00000077189annotation not available (276 aa)
UQCRQUbiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa. (82 aa)
CNTN1CNTN1 isoform 1. (1028 aa)
ENSPTRP00000074763annotation not available (520 aa)
PTPN11-2Protein tyrosine phosphatase non-receptor type 11. (579 aa)
NRXN1NRXN1 isoform 9. (1547 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
ENSPTRP00000070863annotation not available (261 aa)
ENSPTRP00000070307annotation not available (237 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (418 aa)
AGTPBP1ATP/GTP binding protein 1. (1290 aa)
SSTR1Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (391 aa)
WHRNWHRN isoform 2. (907 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
ENSPTRP00000067174annotation not available (502 aa)
MYO16MYO16 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1903 aa)
KLHL5Kelch like family member 5. (757 aa)
FOXC1FOXC1 isoform 1. (550 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
ATP7AATPase, Cu++ transporting, alpha polypeptide. (1500 aa)
CK820_G0054728MECP2 isoform 14. (493 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
LOC10060951378 kDa glucose-regulated protein pseudogene. (617 aa)
CLP1Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (425 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
LHX1LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
AARS1Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
DAB1DAB adaptor protein 1. (588 aa)
PROX1Prospero homeobox 1. (737 aa)
EN1Homeobox protein engrailed-like. (396 aa)
CEND1Cell cycle exit and neuronal differentiation 1. (149 aa)
GARTTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa)
MTPNMTPN isoform 1. (118 aa)
COQ8BAarF domain containing kinase 4. (544 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
ATIC5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (592 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2390 aa)
NLGN4XNeuroligin 4 X-linked. (817 aa)
GLI2GLI family zinc finger 2. (1587 aa)
LDB1LIM domain binding 1. (411 aa)
KLHL4Kelch like family member 4. (718 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
OGDHOxoglutarate dehydrogenase. (1038 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
DIXDC1DIX domain containing 1. (683 aa)
PDSS2Prenyl (Decaprenyl) diphosphate synthase, subunit 2; Belongs to the FPP/GGPP synthase family. (399 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
SLC25A46Solute carrier family 25, member 46; Belongs to the mitochondrial carrier (TC 2.A.29) family. (418 aa)
CPLANE1Ciliogenesis and planar polarity effector 1. (3197 aa)
HNRNPDHNRNPD isoform 1. (356 aa)
TTLL1Tubulin tyrosine ligase-like family, member 1. (404 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (551 aa)
NANOS1Nanos C2HC-type zinc finger 1; Belongs to the nanos family. (290 aa)
ATRNATRN isoform 1. (1429 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
TTC21BTetratricopeptide repeat domain 21B. (1316 aa)
SEMA4CSEMA4C isoform 2; Belongs to the semaphorin family. (833 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1948 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (743 aa)
HAP1HAP1 isoform 2. (667 aa)
SEZ6Seizure related 6 homolog. (994 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
RPGRIP1LRPGRIP1L isoform 4. (1269 aa)
CBLN1Cerebellin 1 precursor. (193 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (515 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
HERC1Hect (Homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1. (4861 aa)
TTBK2TTBK2 isoform 2; Belongs to the intermediate filament family. (1649 aa)
CKBCreatine kinase, brain; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
LHX5LHX5 isoform 2. (402 aa)
FAIM2FAIM2 isoform 2; Belongs to the BI1 family. (316 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
CD3ECD3E isoform 2. (207 aa)
FZD4FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
KCNC1Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family. (585 aa)
KNDC1KNDC1 isoform 1. (1672 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1648 aa)
LMX1ALIM homeobox transcription factor 1 alpha. (382 aa)
HSPA5Heat shock 70kDa protein 5 (Glucose-regulated protein, 78kDa); Belongs to the heat shock protein 70 family. (654 aa)
REREArginine-glutamic acid dipeptide (RE) repeats. (1566 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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