STRINGSTRING
ATP1A2 ATP1A2 ENSPTRP00000082446 ENSPTRP00000082446 CRK CRK KIRREL3 KIRREL3 NHLH2 NHLH2 TBX3 TBX3 ENSPTRP00000085036 ENSPTRP00000085036 MDK MDK SRD5A2 SRD5A2 ENSPTRP00000085189 ENSPTRP00000085189 LOC459638 LOC459638 ENSPTRP00000086358 ENSPTRP00000086358 PHLPP2 PHLPP2 CDK5R2 CDK5R2 ENSPTRP00000088754 ENSPTRP00000088754 ENSPTRP00000088766 ENSPTRP00000088766 PLXNA1 PLXNA1 ENSPTRP00000089256 ENSPTRP00000089256 ENSPTRP00000089450 ENSPTRP00000089450 EZH2-2 EZH2-2 ENSPTRP00000090501 ENSPTRP00000090501 PTEN PTEN NR2E1-2 NR2E1-2 SOX3 SOX3 NDNF NDNF BAX BAX ENSPTRP00000093022 ENSPTRP00000093022 ZIC1 ZIC1 ID4 ID4 NF2 NF2 HTR5A-2 HTR5A-2 NKX2-1 NKX2-1 NR2E1 NR2E1 PPP1R9B PPP1R9B DCX DCX SMO-2 SMO-2 TMEM108 TMEM108 FGF13 FGF13 LOC748850 LOC748850 ZIC3 ZIC3 SEMA3E SEMA3E DRD1 DRD1 ENSPTRP00000065099 ENSPTRP00000065099 ENSPTRP00000065012 ENSPTRP00000065012 CNTNAP2 CNTNAP2 TSC1 TSC1 BBS4 BBS4 RELN RELN RARA RARA CDK5R1 CDK5R1 DAB1 DAB1 HSD3B2 HSD3B2 BCAN BCAN PROX1 PROX1 WNT3A WNT3A SCT SCT TENT2 TENT2 TSKU TSKU CRKL CRKL TBR1 TBR1 CTNNB1 CTNNB1 MFSD2A MFSD2A DLX1 DLX1 PLXNA3 PLXNA3 NKX2-6 NKX2-6 HTR5A HTR5A SMO SMO CDK6 CDK6 OGDH OGDH GLI3 GLI3 NEUROD6 NEUROD6 MAS1 MAS1 SRF SRF ATAT1 ATAT1 OTP OTP SRD5A1 SRD5A1 ANXA3 ANXA3 UBA6 UBA6 EPHA5 EPHA5 EIF2B5 EIF2B5 SLC32A1 SLC32A1 XRN2 XRN2 MKKS MKKS NRP2 NRP2 DLX2 DLX2 RAB3GAP1 RAB3GAP1 ALK ALK PTPRS PTPRS SEMA6B SEMA6B RAX RAX EZH1 EZH1 HAP1 HAP1 NF1 NF1 YWHAE YWHAE BBS2 BBS2 ALDH1A3 ALDH1A3 IGF1R IGF1R FOXB1 FOXB1 GSX1 GSX1 LHX5 LHX5 KCNA1 KCNA1 FEZ1 FEZ1 BBS1 BBS1 FGFR2 FGFR2 EMX2 EMX2 NRP1 NRP1 BTG2 BTG2 KIF14 KIF14 ARPC5 ARPC5 LMX1A LMX1A HSD3B1 HSD3B1 LRP8 LRP8 ENSPTRP00000075494 ENSPTRP00000075494 ATP2B4 ATP2B4 HDAC1 HDAC1 NEFL NEFL UQCRQ UQCRQ EZH2 EZH2 ENSPTRP00000078003 ENSPTRP00000078003 PAFAH1B1 PAFAH1B1 LOC107971060 LOC107971060 ENSPTRP00000078419 ENSPTRP00000078419 LOC107974864 LOC107974864 LEF1 LEF1 FEZF2 FEZF2 DCLK2 DCLK2 ENSPTRP00000080117 ENSPTRP00000080117 CDK5 CDK5 FAM205A FAM205A GSK3B GSK3B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
ENSPTRP00000082446annotation not available (194 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
KIRREL3Kirre like nephrin family adhesion molecule 3. (787 aa)
NHLH2Nescient helix-loop-helix 2. (135 aa)
TBX3T-box transcription factor 3. (743 aa)
ENSPTRP00000085036annotation not available (435 aa)
MDKMidkine (Neurite growth-promoting factor 2). (143 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
ENSPTRP00000085189annotation not available (1896 aa)
LOC45963814-3-3 protein epsilon-like. (255 aa)
ENSPTRP00000086358annotation not available (72 aa)
PHLPP2PHLPP2 isoform 2. (1358 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (367 aa)
ENSPTRP00000088754annotation not available (350 aa)
ENSPTRP00000088766annotation not available (199 aa)
PLXNA1PLXNA1 isoform 1. (1915 aa)
ENSPTRP00000089256annotation not available (359 aa)
ENSPTRP00000089450annotation not available (303 aa)
EZH2-2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
ENSPTRP00000090501annotation not available (192 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
NR2E1-2Nuclear receptor subfamily 2 group E member 1. (385 aa)
SOX3SRY-box transcription factor 3. (446 aa)
NDNFNDNF isoform 1. (568 aa)
BAXBAX isoform 7. (123 aa)
ENSPTRP00000093022annotation not available (563 aa)
ZIC1Zic family member 1. (447 aa)
ID4Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein. (161 aa)
NF2Neurofibromin 2 (Merlin). (595 aa)
HTR5A-25-hydroxytryptamine receptor 5A. (357 aa)
NKX2-1NKX2-1 isoform 1. (401 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (422 aa)
PPP1R9BProtein phosphatase 1, regulatory (Inhibitor) subunit 9B. (817 aa)
DCXDCX isoform 5. (420 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
TMEM108Transmembrane protein 108. (575 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
LOC748850HDAC2 isoform 9. (445 aa)
ZIC3Zic family member 3. (466 aa)
SEMA3ESEMA3E isoform 1; Belongs to the semaphorin family. (775 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
ENSPTRP00000065099annotation not available (337 aa)
ENSPTRP00000065012annotation not available (108 aa)
CNTNAP2Contactin associated protein like 2. (1331 aa)
TSC1TSC complex subunit 1. (1164 aa)
BBS4Bardet-Biedl syndrome 4. (519 aa)
RELNRELN isoform 3. (3460 aa)
RARARARA isoform 4. (624 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
DAB1DAB adaptor protein 1. (588 aa)
HSD3B2Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family. (372 aa)
BCANBCAN isoform 2. (907 aa)
PROX1Prospero homeobox 1. (737 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
SCTSCT isoform 1. (125 aa)
TENT2PAPD4 isoform 1. (484 aa)
TSKUTsukushi, small leucine rich proteoglycan. (353 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
TBR1T-box brain transcription factor 1. (682 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (530 aa)
DLX1Distal-less homeobox 1. (255 aa)
PLXNA3PLXNA3 isoform 1. (1871 aa)
NKX2-6NKX2-6 isoform 1. (301 aa)
HTR5A5-hydroxytryptamine receptor 5A. (357 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
OGDHOxoglutarate dehydrogenase. (1038 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
NEUROD6Neurogenic differentiation factor. (337 aa)
MAS1MAS1 isoform 1; Belongs to the G-protein coupled receptor 1 family. (325 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
ATAT1Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (423 aa)
OTPOrthopedia homeobox. (325 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (259 aa)
ANXA3Annexin. (323 aa)
UBA6Ubiquitin-like modifier-activating enzyme 6. (1052 aa)
EPHA5EPH receptor A5. (1038 aa)
EIF2B5Eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa. (721 aa)
SLC32A1Solute carrier family 32 member 1. (525 aa)
XRN25'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (950 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
DLX2Distal-less homeobox 2. (328 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (988 aa)
ALKTyrosine-protein kinase receptor. (1620 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1948 aa)
SEMA6BSema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6B; Belongs to the semaphorin family. (888 aa)
RAXRetina and anterior neural fold homeobox. (346 aa)
EZH1Enhancer of zeste 1 polycomb repressive complex 2 subunit. (747 aa)
HAP1HAP1 isoform 2. (667 aa)
NF1Neurofibromin 1. (2839 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; Belongs to the 14-3-3 family. (255 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
ALDH1A3Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
FOXB1FOXB1 isoform 3. (325 aa)
GSX1GSX1 isoform 1. (264 aa)
LHX5LHX5 isoform 2. (402 aa)
KCNA1Potassium voltage-gated channel, shaker-related subfamily, member 1 (Episodic ataxia with myokymia); Belongs to the potassium channel family. (495 aa)
FEZ1Fasciculation and elongation protein zeta 1 (Zygin I). (392 aa)
BBS1Bardet-Biedl syndrome 1 protein isoform X1. (593 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
EMX2Empty spiracles homeobox 2. (252 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
BTG2BTG anti-proliferation factor 2. (158 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1648 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
LMX1ALIM homeobox transcription factor 1 alpha. (382 aa)
HSD3B1Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. (373 aa)
LRP8LDL receptor related protein 8. (960 aa)
ENSPTRP00000075494annotation not available (194 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (543 aa)
UQCRQUbiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa. (82 aa)
EZH2Enhancer of zeste homolog 2. (754 aa)
ENSPTRP00000078003annotation not available (847 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (413 aa)
LOC107971060SRD5A1 isoform 2. (141 aa)
ENSPTRP00000078419annotation not available (329 aa)
LOC107974864Cytochrome b-c1 complex subunit 8. (82 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
FEZF2FEZ family zinc finger 2. (463 aa)
DCLK2DCLK2 isoform 5. (783 aa)
ENSPTRP00000080117annotation not available (567 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
FAM205AFAM205A isoform 1. (1298 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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