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SOD1 SOD1 APP APP NCSTN NCSTN ENSPTRP00000093022 ENSPTRP00000093022 NRG1 NRG1 TPPP TPPP SOX11 SOX11 PTEN PTEN ADAM22-2 ADAM22-2 ENSPTRP00000089750 ENSPTRP00000089750 AKT2 AKT2 LAMC3 LAMC3 MXRA8 MXRA8 ROR1 ROR1 CNTN2 CNTN2 MED12 MED12 MDK MDK HDAC11 HDAC11 DMD-2 DMD-2 KRAS KRAS AKT1 AKT1 CSPG5 CSPG5 ITGB4 ITGB4 SH3TC1 SH3TC1 HES5-2 HES5-2 CDK5 CDK5 OLIG1-2 OLIG1-2 ERCC2 ERCC2 ASCL1 ASCL1 ANO1 ANO1 NTRK2 NTRK2 LOC100611979 LOC100611979 SHH SHH TSPAN2 TSPAN2 CNTN1 CNTN1 NSUN5-2 NSUN5-2 ABCA2 ABCA2 ARHGEF10 ARHGEF10 ID4 ID4 LRP1 LRP1 DMD DMD PRDM8 PRDM8 SMO-2 SMO-2 ILK ILK DRD1 DRD1 EIF2B3 EIF2B3 LPAR1 LPAR1 OLIG1 OLIG1 GFAP GFAP C1QA C1QA ADAM22 ADAM22 C5AR1 C5AR1 CNTNAP1 CNTNAP1 POU3F1 POU3F1 SOX4 SOX4 AGER AGER IFNGR1 IFNGR1 CD22-2 CD22-2 DICER1 DICER1 LYN LYN ADGRG6 ADGRG6 PARD3 PARD3 SOX10 SOX10 HES5 HES5 WASF3 WASF3 PLP1 PLP1 ROR2 ROR2 PLEC PLEC NDRG1 NDRG1 CLU CLU SMO SMO CDK6 CDK6 NSUN5 NSUN5 DLL1 DLL1 TREM2 TREM2 SH3TC2 SH3TC2 SLC25A46 SLC25A46 NRROS NRROS EIF2B5 EIF2B5 DAG1 DAG1 LAMB2 LAMB2 PICK1 PICK1 ADORA2A ADORA2A B4GALT5 B4GALT5 NKX2-2 NKX2-2 IL1B IL1B MAL MAL EIF2B4 EIF2B4 TGFB1 TGFB1 PRX PRX SIRT2 SIRT2 LGI4 LGI4 B4GALT6 B4GALT6 GRN GRN NF1 NF1 ASPA ASPA FA2H FA2H MT3 MT3 EIF2B2 EIF2B2 PSEN1 PSEN1 MPP5 MPP5 EIF2B1 EIF2B1 IFNG IFNG TENM4 TENM4 ACY3 ACY3 MYRF MYRF CNTF CNTF NKX6-2 NKX6-2 VIM VIM MYOC MYOC S100A8 S100A8 S100A9 S100A9 PHGDH PHGDH NCMAP NCMAP SKI SKI
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (771 aa)
NCSTNNCSTN isoform 1. (721 aa)
ENSPTRP00000093022annotation not available (563 aa)
NRG1NRG1 isoform 3. (713 aa)
TPPPTubulin polymerization promoting protein. (219 aa)
SOX11Transcription factor SOX. (441 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ADAM22-2ADAM22 isoform 3. (923 aa)
ENSPTRP00000089750annotation not available (448 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LAMC3Laminin subunit gamma 3. (1580 aa)
MXRA8Matrix remodeling associated 8. (446 aa)
ROR1Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (945 aa)
CNTN2CNTN2 isoform 13. (1040 aa)
MED12Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifi [...] (2182 aa)
MDKMidkine (Neurite growth-promoting factor 2). (143 aa)
HDAC11HDAC11 isoform 14. (374 aa)
DMD-2Dystrophin. (643 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
CSPG5Chondroitin sulfate proteoglycan 5. (566 aa)
ITGB4Integrin beta. (1822 aa)
SH3TC1SH3TC1 isoform 2. (1336 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
OLIG1-2OLIG1 isoform 1. (272 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
ANO1Anoctamin. (986 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
LOC100611979Probable 28S rRNA (cytosine-C(5))-methyltransferase. (448 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
TSPAN2Tetraspanin. (228 aa)
CNTN1CNTN1 isoform 1. (1028 aa)
NSUN5-2NOP2/Sun domain family, member 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (466 aa)
ABCA2ABCA2 isoform 8. (2364 aa)
ARHGEF10ARHGEF10 isoform 4. (1416 aa)
ID4Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein. (161 aa)
LRP1LDL receptor related protein 1. (4544 aa)
DMDDMD isoform 3. (3685 aa)
PRDM8PR domain containing 8. (1065 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
ILKIntegrin-linked kinase. (533 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
EIF2B3Eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa. (452 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
OLIG1OLIG1 isoform 2. (272 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (505 aa)
C1QAComplement C1q A chain. (245 aa)
ADAM22ADAM metallopeptidase domain 22. (906 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. (351 aa)
CNTNAP1Contactin associated protein 1. (1384 aa)
POU3F1POU domain protein. (451 aa)
SOX4Transcription factor SOX. (474 aa)
AGERAdvanced glycosylation end-product specific receptor. (420 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
CD22-2B-cell receptor CD22. (626 aa)
DICER1Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily. (1922 aa)
LYNTyrosine-protein kinase. (512 aa)
ADGRG6Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family. (1250 aa)
PARD3PARD3 isoform 2. (1356 aa)
SOX10SRY-box transcription factor 10. (466 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
WASF3WH2 domain-containing protein. (502 aa)
PLP1Proteolipid protein 1. (277 aa)
ROR2Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (943 aa)
PLECPLEC isoform 2. (4684 aa)
NDRG1NDRG1 isoform 2. (394 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
NSUN5NOP2/Sun RNA methyltransferase 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (470 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
SH3TC2SH3TC2 isoform 8. (1288 aa)
SLC25A46Solute carrier family 25, member 46; Belongs to the mitochondrial carrier (TC 2.A.29) family. (418 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
EIF2B5Eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa. (721 aa)
DAG1Dystroglycan 1 (Dystrophin-associated glycoprotein 1). (895 aa)
LAMB2Laminin, beta 2 (Laminin S). (1798 aa)
PICK1Protein interacting with PRKCA 1. (416 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
B4GALT5UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5. (388 aa)
NKX2-2NKX2-2 isoform 1. (273 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
MALMal, T cell differentiation protein. (153 aa)
EIF2B4Eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa; Belongs to the eIF-2B alpha/beta/delta subunits family. (523 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PRXPRX isoform 2. (1371 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
LGI4Leucine rich repeat LGI family member 4. (537 aa)
B4GALT6UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6. (382 aa)
GRNGranulin precursor. (593 aa)
NF1Neurofibromin 1. (2839 aa)
ASPAAspartoacylase (Canavan disease). (313 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa)
MT3MT3 isoform 5; Belongs to the metallothionein superfamily. Type 1 family. (113 aa)
EIF2B2Eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa; Belongs to the eIF-2B alpha/beta/delta subunits family. (351 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
MPP5Membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (675 aa)
EIF2B1Eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa; Belongs to the eIF-2B alpha/beta/delta subunits family. (306 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
TENM4Teneurin transmembrane protein 4. (2769 aa)
ACY3Aspartoacylase (Aminocyclase) 3. (319 aa)
MYRFMYRF isoform 2. (932 aa)
CNTFCiliary neurotrophic factor. (200 aa)
NKX6-2NKX6-2 isoform 1. (276 aa)
VIMVimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. (466 aa)
MYOCMYOC isoform 1. (504 aa)
S100A8Protein S100; Belongs to the S-100 family. (93 aa)
S100A9Protein S100; Belongs to the S-100 family. (114 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (573 aa)
NCMAPNCMAP isoform 2. (102 aa)
SKIV-ski sarcoma viral oncogene homolog (Avian). (736 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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