STRINGSTRING
LRP8 LRP8 BMERB1 BMERB1 COL3A1 COL3A1 GLI3 GLI3 CTNNB1 CTNNB1 CDK5R1 CDK5R1 ADGRG1 ADGRG1 DAB2IP DAB2IP NR2E1-2 NR2E1-2 CDK5R2 CDK5R2 MBOAT7-2 MBOAT7-2 CDK5 CDK5 PAFAH1B1 PAFAH1B1 NR2E1 NR2E1 DCX DCX MBOAT7 MBOAT7 RELN RELN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRP8LDL receptor related protein 8. (960 aa)
BMERB1Uncharacterized protein C16orf45 homolog. (204 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
ADGRG1Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...] (693 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
NR2E1-2Nuclear receptor subfamily 2 group E member 1. (385 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (367 aa)
MBOAT7-2Membrane bound O-acyltransferase domain containing 7. (472 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (413 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (422 aa)
DCXDCX isoform 5. (420 aa)
MBOAT7Membrane bound O-acyltransferase domain containing 7; Belongs to the membrane-bound acyltransferase family. (472 aa)
RELNRELN isoform 3. (3460 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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