STRINGSTRING
DMRTA2 DMRTA2 EMX2 EMX2 WNT1 WNT1 BMP4 BMP4 SIX3 SIX3 TTC21B TTC21B BMP2 BMP2 EOMES EOMES TRA2B TRA2B GSX2 GSX2 GLI3 GLI3 LHX2 LHX2 C2BH2orf66 C2BH2orf66 WNT2B WNT2B LHX1 LHX1 ADGRG1 ADGRG1 EMX1 EMX1 WNT7B WNT7B PAX6 PAX6 NKX2-1 NKX2-1 FGF8 FGF8 SHH SHH FEZF2 FEZF2 BMP4-2 BMP4-2 FEZF1 FEZF1 PGAP1 PGAP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DMRTA2DMRT like family A2. (539 aa)
EMX2Empty spiracles homeobox 2. (252 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SIX3SIX homeobox 3. (331 aa)
TTC21BTetratricopeptide repeat domain 21B. (1316 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
EOMESEOMES isoform 2. (704 aa)
TRA2BTransformer 2 beta homolog. (288 aa)
GSX2GSX2 isoform 2. (304 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
LHX2LHX2 isoform 1. (406 aa)
C2BH2orf66Chromosome 2B C2orf66 homolog. (117 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
LHX1LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
ADGRG1Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...] (693 aa)
EMX1Empty spiracles homeobox 1. (290 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
PAX6PAX6 isoform 13. (436 aa)
NKX2-1NKX2-1 isoform 1. (401 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
FEZF2FEZ family zinc finger 2. (463 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
FEZF1FEZ family zinc finger 1. (475 aa)
PGAP1GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic reticulum to the Golgi. (922 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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