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ZMIZ1 ZMIZ1 NRP1 NRP1 BTG2 BTG2 CHRNB2 CHRNB2 DRAXIN DRAXIN PTEN PTEN SCN1B SCN1B CDH11 CDH11 NR4A2 NR4A2 PLXNA1 PLXNA1 AGBL4 AGBL4 HPRT1 HPRT1 ENSPTRP00000086358 ENSPTRP00000086358 EPHA4 EPHA4 SPG11 SPG11 CNTN2 CNTN2 LHX6 LHX6 ENSPTRP00000084830 ENSPTRP00000084830 NHLH2 NHLH2 DCLK1 DCLK1 NIN NIN TAOK1 TAOK1 CDK5 CDK5 DCLK2 DCLK2 FEZF2 FEZF2 SLIT2 SLIT2 LOC107974864 LOC107974864 RAPGEF2 RAPGEF2 DISC1 DISC1 SCYL2 SCYL2 PAFAH1B1 PAFAH1B1 ENSPTRP00000078003 ENSPTRP00000078003 ASCL1 ASCL1 NTRK2 NTRK2 SLC4A10 SLC4A10 UQCRQ UQCRQ SECISBP2 SECISBP2 KIFBP KIFBP ENSPTRP00000093022 ENSPTRP00000093022 NDNF NDNF NR2E1-2 NR2E1-2 ARHGAP35 ARHGAP35 SPTBN4 SPTBN4 CK820_G0025552 CK820_G0025552 NR2E1 NR2E1 EPHB3 EPHB3 LEP LEP LHX8 LHX8 NDEL1-2 NDEL1-2 ARX ARX DRD2 DRD2 AGTPBP1 AGTPBP1 ENSPTRP00000068492 ENSPTRP00000068492 DCC DCC DCX DCX SEMA3E SEMA3E DRD1 DRD1 ATP7A ATP7A MYCBP2 MYCBP2 SOX1 SOX1 PLXNA4 PLXNA4 NFIB NFIB TCTN1 TCTN1 EPHB1 EPHB1 GATA2 GATA2 FOXG1 FOXG1 EPHB2 EPHB2 LINGO1 LINGO1 NOVA2 NOVA2 TSKU TSKU GLI2 GLI2 MAP2 MAP2 PLXNA3 PLXNA3 GBA2 GBA2 EPHB6 EPHB6 OGDH OGDH NPY NPY HSP90AB1 HSP90AB1 GABRB1 GABRB1 PHOX2B PHOX2B FBXO45 FBXO45 RAC3 RAC3 ADARB1 ADARB1 B4GALT5 B4GALT5 GBX2 GBX2 NRP2 NRP2 B4GALT6 B4GALT6 LRRC45 LRRC45 NDEL1 NDEL1 MPP5 MPP5 CK820_G0016130 CK820_G0016130 TTC36 TTC36 FGFR2 FGFR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZMIZ1Zinc finger, MIZ-type containing 1. (1073 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
BTG2BTG anti-proliferation factor 2. (158 aa)
CHRNB2CHRNB2 isoform 2. (502 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SCN1BSodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. (268 aa)
CDH11Cadherin 11, type 2, OB-cadherin (Osteoblast); Cadherins are calcium-dependent cell adhesion proteins. (811 aa)
NR4A2Nuclear receptor subfamily 4, group A, member 2. (598 aa)
PLXNA1PLXNA1 isoform 1. (1915 aa)
AGBL4ATP/GTP binding protein like 4. (503 aa)
HPRT1Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). (218 aa)
ENSPTRP00000086358annotation not available (72 aa)
EPHA4EPH receptor A4. (986 aa)
SPG11SPG11 isoform 4. (2443 aa)
CNTN2CNTN2 isoform 13. (1040 aa)
LHX6LHX6 isoform 3. (428 aa)
ENSPTRP00000084830annotation not available (340 aa)
NHLH2Nescient helix-loop-helix 2. (135 aa)
DCLK1Doublecortin like kinase 1. (740 aa)
NINNIN isoform 1. (2133 aa)
TAOK1TAOK1 isoform 2. (973 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
DCLK2DCLK2 isoform 5. (783 aa)
FEZF2FEZ family zinc finger 2. (463 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
LOC107974864Cytochrome b-c1 complex subunit 8. (82 aa)
RAPGEF2RAPGEF2 isoform 2. (1701 aa)
DISC1Disrupted in schizophrenia 1 protein isoform X1. (977 aa)
SCYL2SCYL2 isoform 1. (962 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (413 aa)
ENSPTRP00000078003annotation not available (847 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
SLC4A10Anion exchange protein. (1138 aa)
UQCRQUbiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa. (82 aa)
SECISBP2SECIS binding protein 2. (855 aa)
KIFBPKIF1BP isoform 9. (646 aa)
ENSPTRP00000093022annotation not available (563 aa)
NDNFNDNF isoform 1. (568 aa)
NR2E1-2Nuclear receptor subfamily 2 group E member 1. (385 aa)
ARHGAP35Glucocorticoid receptor DNA binding factor 1. (1519 aa)
SPTBN4Spectrin beta, non-erythrocytic 4. (2565 aa)
CK820_G0025552SZT2 isoform 2. (3432 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (422 aa)
EPHB3EPHB3 isoform 1. (1031 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
LHX8LHX8 isoform 2. (377 aa)
NDEL1-2NudE nuclear distribution gene E homolog-like 1. (351 aa)
ARXARX isoform 1. (559 aa)
DRD2D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (490 aa)
AGTPBP1ATP/GTP binding protein 1. (1290 aa)
ENSPTRP00000068492annotation not available (777 aa)
DCCDCC isoform 1. (1457 aa)
DCXDCX isoform 5. (420 aa)
SEMA3ESEMA3E isoform 1; Belongs to the semaphorin family. (775 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
ATP7AATPase, Cu++ transporting, alpha polypeptide. (1500 aa)
MYCBP2MYCBP2 isoform 2. (4750 aa)
SOX1SOX1 isoform 1. (391 aa)
PLXNA4PLXNA4 isoform 1. (1894 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
TCTN1Tectonic family member 1. (592 aa)
EPHB1EPH receptor B1. (984 aa)
GATA2GATA binding protein 2. (480 aa)
FOXG1FOXG1 isoform 8. (489 aa)
EPHB2EPH receptor B2. (1055 aa)
LINGO1Leucine rich repeat and Ig domain containing 1. (620 aa)
NOVA2NOVA alternative splicing regulator 2. (492 aa)
TSKUTsukushi, small leucine rich proteoglycan. (353 aa)
GLI2GLI family zinc finger 2. (1587 aa)
MAP2Microtubule-associated protein. (1827 aa)
PLXNA3PLXNA3 isoform 1. (1871 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (927 aa)
EPHB6Ephrin type-B receptor 6; Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (By similarity). (1020 aa)
OGDHOxoglutarate dehydrogenase. (1038 aa)
NPYNeuropeptide Y. (97 aa)
HSP90AB1HSP90AB1 isoform 1. (688 aa)
GABRB1Gamma-aminobutyric acid type A receptor beta1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (474 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
FBXO45F-box protein 45. (286 aa)
RAC3Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3). (205 aa)
ADARB1ADARB1 isoform 13. (741 aa)
B4GALT5UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5. (388 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
B4GALT6UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6. (382 aa)
LRRC45Leucine rich repeat containing 45. (670 aa)
NDEL1NudE nuclear distribution gene E homolog-like 1. (345 aa)
MPP5Membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (675 aa)
CK820_G0016130SCYL2 isoform 5. (871 aa)
TTC36TTC36 isoform 3. (206 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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