45 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOX3	SRY-box transcription factor 3. (446 aa)
	INHBB	Inhibin subunit beta B. (407 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (500 aa)
	LOC107971060	SRD5A1 isoform 2. (141 aa)
	GLI1	GLI family zinc finger 1. (1106 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	GHRHR-2	Growth hormone-releasing hormone receptor isoform X1. (447 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	GHRHR	Growth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
	LHX3	LHX3 isoform 2. (402 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	GATA2	GATA binding protein 2. (480 aa)
	SOX2	SRY-box transcription factor 2. (319 aa)
	GLI2	GLI family zinc finger 2. (1587 aa)
	PROP1	PROP paired-like homeobox 1. (226 aa)
	PITX1	Homeobox protein. (314 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	SRD5A1	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (259 aa)
	SLC6A3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
	PITX2	Homeobox protein. (324 aa)
	POU1F1	POU domain protein. (317 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	GSX1	GSX1 isoform 1. (264 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	HESX1	Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity). (185 aa)
	GHRH	Growth hormone releasing hormone. (108 aa)
	BMP2	Bone morphogenetic protein 2. (398 aa)
	SIX3	SIX homeobox 3. (331 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	CDH1	CDH1 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
	ALDH1A2	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
	ENSPTRP00000064416	annotation not available (502 aa)
	DUOX2	DUOX2 isoform 1. (1548 aa)
	SALL1	SALL1 isoform 2. (1326 aa)
	OTP	Orthopedia homeobox. (325 aa)
	TBX19	T-box transcription factor 19. (448 aa)
	PAX6	PAX6 isoform 13. (436 aa)
	PCSK1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (753 aa)
	DRD2	D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (490 aa)
	ENSPTRP00000069764	annotation not available (1213 aa)
	NKX2-1	NKX2-1 isoform 1. (401 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1A2	GLI2	ENSPTRP00000012165	ENSPTRP00000040313	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family.	GLI family zinc finger 2.	0.512
BMP2	BMP4	ENSPTRP00000022701	ENSPTRP00000010780	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.951
BMP2	BMP4-2	ENSPTRP00000022701	ENSPTRP00000080656	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.530
BMP2	BMPR1A	ENSPTRP00000022701	ENSPTRP00000004727	Bone morphogenetic protein 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.996
BMP2	ENSPTRP00000064416	ENSPTRP00000022701	ENSPTRP00000064416	Bone morphogenetic protein 2.	annotation not available	0.964
BMP2	FGF10	ENSPTRP00000022701	ENSPTRP00000083399	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.574
BMP2	FGF8	ENSPTRP00000022701	ENSPTRP00000075677	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.662
BMP2	NOG	ENSPTRP00000022701	ENSPTRP00000016018	Bone morphogenetic protein 2.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.998
BMP2	PITX2	ENSPTRP00000022701	ENSPTRP00000028118	Bone morphogenetic protein 2.	Homeobox protein.	0.410
BMP2	TBX19	ENSPTRP00000022701	ENSPTRP00000064932	Bone morphogenetic protein 2.	T-box transcription factor 19.	0.407
BMP2	WNT4	ENSPTRP00000022701	ENSPTRP00000063328	Bone morphogenetic protein 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.426
BMP2	WNT5A	ENSPTRP00000022701	ENSPTRP00000086163	Bone morphogenetic protein 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.416
BMP4	BMP2	ENSPTRP00000010780	ENSPTRP00000022701	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.951
BMP4	BMPR1A	ENSPTRP00000010780	ENSPTRP00000004727	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.988
BMP4	ENSPTRP00000064416	ENSPTRP00000010780	ENSPTRP00000064416	Bone morphogenetic protein 4.	annotation not available	0.846
BMP4	FGF10	ENSPTRP00000010780	ENSPTRP00000083399	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.696
BMP4	FGF8	ENSPTRP00000010780	ENSPTRP00000075677	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.724
BMP4	GLI1	ENSPTRP00000010780	ENSPTRP00000078209	Bone morphogenetic protein 4.	GLI family zinc finger 1.	0.444
BMP4	ISL1	ENSPTRP00000010780	ENSPTRP00000028882	Bone morphogenetic protein 4.	ISL LIM homeobox 1.	0.409
BMP4	NOG	ENSPTRP00000010780	ENSPTRP00000016018	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.998