STRINGSTRING
NR2E1 NR2E1 PPP1R9B PPP1R9B NDE1 NDE1 ROBO1 ROBO1 POU3F3 POU3F3 NSUN5-2 NSUN5-2 ENSPTRP00000075494 ENSPTRP00000075494 SUN1 SUN1 LOC100611979 LOC100611979 NEFL NEFL NTRK2 NTRK2 ASCL1 ASCL1 SLC2A1 SLC2A1 EFHC1 EFHC1 PAFAH1B1 PAFAH1B1 LOC107971060 LOC107971060 ENSPTRP00000078378 ENSPTRP00000078378 DISC1 DISC1 SLIT2 SLIT2 CDK5 CDK5 TMEM14B TMEM14B GSK3B GSK3B MBOAT7-2 MBOAT7-2 ENSPTRP00000082446 ENSPTRP00000082446 GART-2 GART-2 CRK CRK ENSPTRP00000084287 ENSPTRP00000084287 DMD-2 DMD-2 TACC1 TACC1 FUT10 FUT10 SMO SMO NSUN5 NSUN5 GLI3 GLI3 NPY NPY DIXDC1 DIXDC1 AKIRIN2 AKIRIN2 CEP120 CEP120 SRD5A1 SRD5A1 TACC3 TACC3 FBXO45 FBXO45 TRA2B TRA2B RHOA RHOA EOMES EOMES BTBD3 BTBD3 MKKS MKKS PLCB1 PLCB1 COL3A1 COL3A1 CCDC141 CCDC141 PEX13 PEX13 WDR62 WDR62 PTPRS PTPRS NARS1 NARS1 NF1 NF1 NDEL1 NDEL1 YWHAE YWHAE BBS2 BBS2 BMERB1 BMERB1 CCDC85C CCDC85C PSEN1 PSEN1 MPP5 MPP5 HIF1A HIF1A H2AFX H2AFX BBS1 BBS1 TH TH BNIP3 BNIP3 TACC2 TACC2 EMX2 EMX2 ZMIZ1 ZMIZ1 KIF14 KIF14 LRP8 LRP8 DMRTA2 DMRTA2 HTR6 HTR6 ENSPTRP00000084830 ENSPTRP00000084830 LHX6 LHX6 MDK MDK ENSPTRP00000085189 ENSPTRP00000085189 LOC459638 LOC459638 CDK5R2 CDK5R2 ENSPTRP00000088766 ENSPTRP00000088766 TRAPPC9 TRAPPC9 ENSPTRP00000089450 ENSPTRP00000089450 ENSPTRP00000089750 ENSPTRP00000089750 ENSPTRP00000090501 ENSPTRP00000090501 NR2E1-2 NR2E1-2 SUN1-2 SUN1-2 BAX BAX CDH2 CDH2 MCPH1 MCPH1 BAD BAD LHX2 LHX2 XAB2 XAB2 ATIC ATIC CTNNB1 CTNNB1 GART GART TBR1 TBR1 CRKL CRKL MDGA1 MDGA1 SUN2 SUN2 PAX5 PAX5 SRGAP2 SRGAP2 ASPM ASPM DAB1 DAB1 FOXG1 FOXG1 CDK5R1 CDK5R1 ATOH1 ATOH1 CSNK2A2 CSNK2A2 ADGRG1 ADGRG1 RTN4 RTN4 DAB2IP DAB2IP RELN RELN BBS4 BBS4 EMX1 EMX1 MBOAT7 MBOAT7 FAT4 FAT4 KDM1A KDM1A TSC1 TSC1 CNTNAP2 CNTNAP2 ENSPTRP00000065012 ENSPTRP00000065012 PAX6 PAX6 FGF13 FGF13 SMO-2 SMO-2 DCX DCX PHACTR1 PHACTR1 SYNE2 SYNE2 PEX5 PEX5 ATP1A3 ATP1A3 CDON CDON ENSPTRP00000068866 ENSPTRP00000068866 LAMB1 LAMB1 DMD DMD EGFR EGFR ARX ARX NDEL1-2 NDEL1-2 FOXP2 FOXP2 MGARP MGARP NKX2-1 NKX2-1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NR2E1Nuclear receptor subfamily 2 group E member 1. (422 aa)
PPP1R9BProtein phosphatase 1, regulatory (Inhibitor) subunit 9B. (817 aa)
NDE1NudE nuclear distribution gene E homolog 1. (359 aa)
ROBO1Roundabout guidance receptor 1. (1684 aa)
POU3F3POU domain protein. (476 aa)
NSUN5-2NOP2/Sun domain family, member 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (466 aa)
ENSPTRP00000075494annotation not available (194 aa)
SUN1SUN1 isoform 2. (925 aa)
LOC100611979Probable 28S rRNA (cytosine-C(5))-methyltransferase. (448 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (543 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
SLC2A1Solute carrier family 2 (Facilitated glucose transporter), member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
EFHC1EF-hand domain containing 1. (641 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (413 aa)
LOC107971060SRD5A1 isoform 2. (141 aa)
ENSPTRP00000078378annotation not available (290 aa)
DISC1Disrupted in schizophrenia 1 protein isoform X1. (977 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
TMEM14BT0060485 isoform 1. (151 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
MBOAT7-2Membrane bound O-acyltransferase domain containing 7. (472 aa)
ENSPTRP00000082446annotation not available (194 aa)
GART-2annotation not available (1010 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
ENSPTRP00000084287annotation not available (136 aa)
DMD-2Dystrophin. (643 aa)
TACC1Transforming, acidic coiled-coil containing protein 1. (806 aa)
FUT10Alpha-(1,3)-fucosyltransferase; Probable fucosyltransferase; Belongs to the glycosyltransferase 10 family. (481 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
NSUN5NOP2/Sun RNA methyltransferase 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (470 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
NPYNeuropeptide Y. (97 aa)
DIXDC1DIX domain containing 1. (683 aa)
AKIRIN2AKIRIN2 isoform 1. (203 aa)
CEP120Centrosomal protein 120kDa. (986 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (259 aa)
TACC3Transforming acidic coiled-coil containing protein 3. (838 aa)
FBXO45F-box protein 45. (286 aa)
TRA2BTransformer 2 beta homolog. (288 aa)
RHOARas homolog family member A. (193 aa)
EOMESEOMES isoform 2. (704 aa)
BTBD3BTB (POZ) domain containing 3. (522 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
CCDC141Coiled-coil domain containing 141. (955 aa)
PEX13Peroxisomal biogenesis factor 13. (403 aa)
WDR62WDR62 isoform 2. (1523 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1948 aa)
NARS1Asparaginyl-tRNA synthetase, cytoplasmic. (558 aa)
NF1Neurofibromin 1. (2839 aa)
NDEL1NudE nuclear distribution gene E homolog-like 1. (345 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; Belongs to the 14-3-3 family. (255 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
BMERB1Uncharacterized protein C16orf45 homolog. (204 aa)
CCDC85CCoiled-coil domain containing 85C. (419 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
MPP5Membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (675 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
H2AFXH2AFX isoform 1. (143 aa)
BBS1Bardet-Biedl syndrome 1 protein isoform X1. (593 aa)
THTyrosine hydroxylase. (528 aa)
BNIP3BCL2 interacting protein 3. (259 aa)
TACC2Transforming acidic coiled-coil containing protein 2. (1094 aa)
EMX2Empty spiracles homeobox 2. (252 aa)
ZMIZ1Zinc finger, MIZ-type containing 1. (1073 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1648 aa)
LRP8LDL receptor related protein 8. (960 aa)
DMRTA2DMRT like family A2. (539 aa)
HTR65-hydroxytryptamine receptor 6; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (By similarity). (440 aa)
ENSPTRP00000084830annotation not available (340 aa)
LHX6LHX6 isoform 3. (428 aa)
MDKMidkine (Neurite growth-promoting factor 2). (143 aa)
ENSPTRP00000085189annotation not available (1896 aa)
LOC45963814-3-3 protein epsilon-like. (255 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (367 aa)
ENSPTRP00000088766annotation not available (199 aa)
TRAPPC9Trafficking protein particle complex 9. (1246 aa)
ENSPTRP00000089450annotation not available (303 aa)
ENSPTRP00000089750annotation not available (448 aa)
ENSPTRP00000090501annotation not available (192 aa)
NR2E1-2Nuclear receptor subfamily 2 group E member 1. (385 aa)
SUN1-2SUN1 isoform 10. (904 aa)
BAXBAX isoform 7. (123 aa)
CDH2Cadherin 2, type 1, N-cadherin (Neuronal); Cadherins are calcium-dependent cell adhesion proteins. (914 aa)
MCPH1Microcephalin; Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex (By similarity). (851 aa)
BADBcl2-associated agonist of cell death. (168 aa)
LHX2LHX2 isoform 1. (406 aa)
XAB2XPA binding protein 2. (855 aa)
ATIC5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (592 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
GARTTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa)
TBR1T-box brain transcription factor 1. (682 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
MDGA1MAM domain containing glycosylphosphatidylinositol anchor 1. (955 aa)
SUN2Sad1 and UNC84 domain containing 2. (717 aa)
PAX5PAX5 isoform 1. (391 aa)
SRGAP2SRGAP2 isoform 1. (1071 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3477 aa)
DAB1DAB adaptor protein 1. (588 aa)
FOXG1FOXG1 isoform 8. (489 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
ATOH1Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). (356 aa)
CSNK2A2Casein kinase 2, alpha prime polypeptide; Belongs to the protein kinase superfamily. (350 aa)
ADGRG1Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...] (693 aa)
RTN4Reticulon. (1192 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
RELNRELN isoform 3. (3460 aa)
BBS4Bardet-Biedl syndrome 4. (519 aa)
EMX1Empty spiracles homeobox 1. (290 aa)
MBOAT7Membrane bound O-acyltransferase domain containing 7; Belongs to the membrane-bound acyltransferase family. (472 aa)
FAT4FAT tumor suppressor homolog 4. (4983 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
TSC1TSC complex subunit 1. (1164 aa)
CNTNAP2Contactin associated protein like 2. (1331 aa)
ENSPTRP00000065012annotation not available (108 aa)
PAX6PAX6 isoform 13. (436 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
DCXDCX isoform 5. (420 aa)
PHACTR1Phosphatase and actin regulator. (649 aa)
SYNE2SYNE2 isoform 1. (6907 aa)
PEX5Peroxisomal biogenesis factor 5. (639 aa)
ATP1A3ATP1A3 isoform 2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1287 aa)
CDONCell adhesion associated, oncogene regulated. (1286 aa)
ENSPTRP00000068866annotation not available (532 aa)
LAMB1LAMB1 isoform 5. (1789 aa)
DMDDMD isoform 3. (3685 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ARXARX isoform 1. (559 aa)
NDEL1-2NudE nuclear distribution gene E homolog-like 1. (351 aa)
FOXP2Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). (741 aa)
MGARPMitochondria localized glutamic acid rich protein. (240 aa)
NKX2-1NKX2-1 isoform 1. (401 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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