STRINGSTRING
LGALS9 LGALS9 FGL2-2 FGL2-2 NEXMIF NEXMIF PTEN PTEN ICOSLG ICOSLG MYADM MYADM MBP MBP PDCD1LG2 PDCD1LG2 ENSPTRP00000092837 ENSPTRP00000092837 RUNX1 RUNX1 ENSPTRP00000093022 ENSPTRP00000093022 SCRIB-2 SCRIB-2 PTPN22 PTPN22 TNFRSF14 TNFRSF14 MAD2L2 MAD2L2 PLA2G2D PLA2G2D PLA2G2F PLA2G2F RUNX3 RUNX3 LAPTM5 LAPTM5 GLMN GLMN TNFAIP8L2 TNFAIP8L2 ZBTB7B ZBTB7B ILDR2 ILDR2 TNFSF4 TNFSF4 RC3H1 RC3H1 TNR TNR LAX1 LAX1 IL10 IL10 HLX HLX GTPBP4 GTPBP4 IL2RA IL2RA PRKG1 PRKG1 DLG5 DLG5 RAG2 RAG2 SCGB1A1 SCGB1A1 CD9 CD9 WNT1 WNT1 NCKAP1L NCKAP1L PAWR PAWR SH2B3 SH2B3 RGCC RGCC METTL3 METTL3 CTSG CTSG BMP4 BMP4 LGALS3 LGALS3 ARG2 ARG2 MAP2K5 MAP2K5 ABAT ABAT SOCS1 SOCS1 IL4R IL4R CDH1 CDH1 ADAMTS18 ADAMTS18 ALOX12 ALOX12 MAPK7 MAPK7 TBX21 TBX21 FOXJ1 FOXJ1 TWSG1 TWSG1 SMAD7 SMAD7 SOCS6 SOCS6 CLEC4G CLEC4G CCL25 CCL25 PRDX2 PRDX2 IFNL1 IFNL1 TGFB1 TGFB1 CEACAM1 CEACAM1 LILRB1 LILRB1 ZC3H8 ZC3H8 ABCA12 ABCA12 IHH IHH SERPINE2 SERPINE2 BMP2 BMP2 JAG1 JAG1 PPM1F PPM1F ADORA2A ADORA2A PPARA PPARA PRKCD PRKCD CBLB CBLB TIGIT TIGIT CD80 CD80 CD86 CD86 IL20RB IL20RB ADIPOQ ADIPOQ IL2 IL2 TMEM131L TMEM131L IRF1 IRF1 IL4 IL4 NDFIP1 NDFIP1 HAVCR2 HAVCR2 BMP6 BMP6 ADTRP ADTRP TNFRSF21 TNFRSF21 LRRC1 LRRC1 ARG1 ARG1 PLG PLG GLI3 GLI3 FGL1 FGL1 ZNF703 ZNF703 IDO1 IDO1 PAG1 PAG1 CD274 CD274 IFNB1 IFNB1 CCL21 CCL21 KLF4 KLF4 AKNA AKNA RC3H2 RC3H2 ASS1 ASS1 NOTCH1 NOTCH1 FOXP3 FOXP3 VSIG4 VSIG4 CD300A CD300A PELI1 PELI1 VSIR VSIR JAK3 JAK3 ITCH ITCH LAG3 LAG3 ENSPTRP00000043137 ENSPTRP00000043137 PDE5A PDE5A NRARP NRARP PRKAR1A PRKAR1A GIMAP1 GIMAP1 CRTAM CRTAM FGL2 FGL2 CD74 CD74 ANXA1 ANXA1 PTPN6 PTPN6 SPN SPN CASP3 CASP3 IL4I1 IL4I1 PATR-G PATR-G MAD1L1 MAD1L1 NOTCH4 NOTCH4 MUC21 MUC21 CBFB CBFB DUSP3 DUSP3 TARM1 TARM1 SOCS5 SOCS5 CK820_G0012168 CK820_G0012168 EPB41L5 EPB41L5 SCRIB SCRIB ENSPTRP00000062039 ENSPTRP00000062039 DEF6 DEF6 BTN2A2 BTN2A2 MARCHF7 MARCHF7 VTCN1 VTCN1 ENSPTRP00000066549 ENSPTRP00000066549 ENSPTRP00000066724 ENSPTRP00000066724 DLG1 DLG1 SPN-2 SPN-2 FXYD5 FXYD5 CXCL12 CXCL12 LRRC32 LRRC32 BCL6 BCL6 SWAP70 SWAP70 ENSPTRP00000068326 ENSPTRP00000068326 TSPAN32 TSPAN32 ZC3H12A ZC3H12A DUSP22 DUSP22 LOC468520 LOC468520 UBASH3B UBASH3B ERBB2 ERBB2 CK820_G0030371 CK820_G0030371 LOC461877 LOC461877 LOC100609621 LOC100609621 ENSPTRP00000071015 ENSPTRP00000071015 ENSPTRP00000071088 ENSPTRP00000071088 LILRB4 LILRB4 IL4-2 IL4-2 NF2 NF2 PTPN2 PTPN2 ABL1 ABL1 RDX RDX PODXL PODXL ENSPTRP00000073371 ENSPTRP00000073371 ENSPTRP00000073414 ENSPTRP00000073414 LOXL3 LOXL3 PRNP PRNP CCL28 CCL28 SHH SHH C1QTNF6 C1QTNF6 WNK1 WNK1 CDKN2A CDKN2A SFTPD SFTPD HFE HFE MIA3 MIA3 C1QTNF1 C1QTNF1 IL1RN IL1RN LEF1 LEF1 CTLA4 CTLA4 TNFSF18 TNFSF18 BMP4-2 BMP4-2 JAK2 JAK2 CK820_G0028374 CK820_G0028374 AKT1 AKT1 SDC4 SDC4 FGG FGG PTK2 PTK2 SPI1 SPI1 MDK MDK ENSPTRP00000085461 ENSPTRP00000085461 TRPV4 TRPV4 CEBPB CEBPB ENSPTRP00000086247 ENSPTRP00000086247 EPCAM EPCAM YTHDF2 YTHDF2 GPNMB GPNMB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LGALS9Galectin. (355 aa)
FGL2-2Fibrinogen like 2. (439 aa)
NEXMIFNeurite extension and migration factor. (1516 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ICOSLGICOSLG isoform 3. (590 aa)
MYADMMyeloid-associated differentiation marker. (322 aa)
MBPMyelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). (304 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (288 aa)
ENSPTRP00000092837annotation not available (325 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
ENSPTRP00000093022annotation not available (563 aa)
SCRIB-2Scribbled homolog. (1662 aa)
PTPN22Protein tyrosine phosphatase, non-receptor type 22 (Lymphoid). (807 aa)
TNFRSF14Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator). (283 aa)
MAD2L2MAD2 mitotic arrest deficient-like 2. (211 aa)
PLA2G2DPhospholipase A(2). (161 aa)
PLA2G2FPhospholipase A(2). (211 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
LAPTM5Lysosomal protein transmembrane 5. (262 aa)
GLMNGlomulin, FKBP associated protein. (594 aa)
TNFAIP8L2TNF alpha induced protein 8 like 2. (184 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (573 aa)
ILDR2Immunoglobulin like domain containing receptor 2. (639 aa)
TNFSF4Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (183 aa)
RC3H1Ring finger and CCCH-type domains 1. (1134 aa)
TNRTNR isoform 1. (1358 aa)
LAX1Lymphocyte transmembrane adaptor 1. (398 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
HLXH2.0-like homeobox. (493 aa)
GTPBP4Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (522 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (272 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1919 aa)
RAG2Recombination activating 2. (527 aa)
SCGB1A1Secretoglobin family 1A member 1. (91 aa)
CD9Tetraspanin. (228 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
NCKAP1LNCK associated protein 1 like. (1127 aa)
PAWRPRKC, apoptosis, WT1, regulator. (340 aa)
SH2B3SH2B adaptor protein 3. (575 aa)
RGCCChromosome 13 open reading frame 15. (137 aa)
METTL3N6-adenosine-methyltransferase 70 kDa subunit; Belongs to the MT-A70-like family. (580 aa)
CTSGCTSG isoform 2; Belongs to the peptidase S1 family. (255 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
LGALS3Galectin. (250 aa)
ARG2Arginase. (354 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (515 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
IL4RIL4R isoform 2. (827 aa)
CDH1CDH1 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
ADAMTS18ADAMTS18 isoform 1. (1221 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa)
TBX21T-box transcription factor 21. (535 aa)
FOXJ1FOXJ1 isoform 1. (421 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
CCL25C-C motif chemokine ligand 25. (150 aa)
PRDX2PRDX2 isoform 1. (198 aa)
IFNL1Interferon lambda 1. (200 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CEACAM1CEACAM1 isoform 3. (518 aa)
LILRB1LILRB1 isoform 3. (697 aa)
ZC3H8Zinc finger CCCH-type containing 8. (291 aa)
ABCA12ATP binding cassette subfamily A member 12. (2595 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
PPM1FPPM1F isoform 4. (454 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (467 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
CBLBCas-Br-M (Murine) ecotropic retroviral transforming sequence b. (982 aa)
TIGITTIGIT isoform 1. (311 aa)
CD80CD80 isoform 1. (288 aa)
CD86CD86 isoform 3. (329 aa)
IL20RBInterleukin 20 receptor subunit beta. (311 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
TMEM131LTMEM131L isoform 3. (1617 aa)
IRF1Interferon regulatory factor. (325 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. (153 aa)
NDFIP1Nedd4 family interacting protein 1. (221 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (301 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
ADTRPAndrogen dependent TFPI regulating protein. (248 aa)
TNFRSF21TNFRSF21 isoform 1. (655 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
ARG1Arginase. (322 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (813 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
FGL1Fibrinogen like 1. (312 aa)
ZNF703Zinc finger protein 703. (590 aa)
IDO1IDO1 isoform 2. (403 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (432 aa)
CD274CD274 isoform 2. (290 aa)
IFNB1Interferon beta 1. (187 aa)
CCL21C-C motif chemokine ligand 21. (134 aa)
KLF4Kruppel-like factor 4 (Gut). (479 aa)
AKNAAT-hook transcription factor. (1440 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
ASS1Argininosuccinate synthetase 1. (412 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
FOXP3FOXP3 isoform 4. (456 aa)
VSIG4V-set and immunoglobulin domain containing 4. (399 aa)
CD300ACD300A isoform 1. (299 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
VSIRChromosome 10 open reading frame 54. (311 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
LAG3LAG3 isoform 3. (527 aa)
ENSPTRP00000043137Galectin-1. (130 aa)
PDE5APhosphodiesterase. (875 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
PRKAR1AProtein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1). (381 aa)
GIMAP1GTPase IMAP family member 5. (500 aa)
CRTAMCytotoxic and regulatory T cell molecule. (393 aa)
FGL2Fibrinogen-like 2. (439 aa)
CD74CD74 isoform 5. (296 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
SPNSPN isoform 3. (400 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
IL4I1Amine oxidase. (589 aa)
PATR-GPatr class I histocompatibility antigen, alpha chain G; Involved in the presentation of foreign antigens to the immune system. (371 aa)
MAD1L1MAD1 mitotic arrest deficient-like 1. (718 aa)
NOTCH4NOTCH4 isoform 3. (2006 aa)
MUC21MUC21 isoform 2. (112 aa)
CBFBCore-binding factor, beta subunit. (182 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
TARM1TARM1 isoform 1. (274 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (733 aa)
SCRIBSCRIB isoform 8. (959 aa)
ENSPTRP00000062039annotation not available (397 aa)
DEF6DEF6 guanine nucleotide exchange factor. (631 aa)
BTN2A2Butyrophilin subfamily 2 member A2. (532 aa)
MARCHF7MARCH7 isoform 6. (666 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (285 aa)
ENSPTRP00000066549annotation not available (154 aa)
ENSPTRP00000066724annotation not available (166 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
SPN-2SPN isoform 1. (418 aa)
FXYD5FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (194 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
LRRC32Leucine rich repeat containing 32. (662 aa)
BCL6BCL6 transcription repressor. (706 aa)
SWAP70SWAP70 isoform 1. (585 aa)
ENSPTRP00000068326annotation not available (488 aa)
TSPAN32TSPAN32 isoform 3; Belongs to the tetraspanin (TM4SF) family. (320 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
DUSP22Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (205 aa)
LOC468520Zinc finger protein 271. (672 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (649 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
CK820_G0030371Galectin. (135 aa)
LOC461877Argininosuccinate synthase pseudogene. (389 aa)
LOC100609621Argininosuccinate synthase pseudogene. (245 aa)
ENSPTRP00000071015annotation not available (408 aa)
ENSPTRP00000071088annotation not available (500 aa)
LILRB4LILRB4 isoform 7. (449 aa)
IL4-2Interleukin 4. (153 aa)
NF2Neurofibromin 2 (Merlin). (595 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (421 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
RDXRDX isoform 3. (609 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (556 aa)
ENSPTRP00000073371annotation not available (431 aa)
ENSPTRP00000073414annotation not available (393 aa)
LOXL3Lysyl oxidase-like 3. (753 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (253 aa)
CCL28C-C motif chemokine. (127 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
C1QTNF6C1q and tumor necrosis factor related protein 6. (278 aa)
WNK1WNK1 isoform 4. (2833 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A (Melanoma, p16, inhibits CDK4). (173 aa)
SFTPDSurfactant protein D. (375 aa)
HFEHereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. (348 aa)
MIA3MIA3 isoform 1. (1983 aa)
C1QTNF1C1q and tumor necrosis factor related protein 1. (281 aa)
IL1RNInterleukin-1. (180 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
TNFSF18Tumor necrosis factor ligand 2A. (199 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
CK820_G0028374Galectin. (343 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
FGGFibrinogen gamma chain. (453 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
SPI1Spi-1 proto-oncogene. (270 aa)
MDKMidkine (Neurite growth-promoting factor 2). (143 aa)
ENSPTRP00000085461annotation not available (478 aa)
TRPV4Transient receptor potential cation channel, subfamily V, member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
ENSPTRP00000086247annotation not available (513 aa)
EPCAMEPCAM isoform 1. (338 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (595 aa)
GPNMBGPNMB isoform 2. (574 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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