112 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NOTCH2	NOTCH2 isoform 1. (2612 aa)
	EPHA2	EPH receptor A2. (976 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	MKI67	MKI67 isoform 1. (3257 aa)
	PGR	Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. (933 aa)
	BSX	Brain specific homeobox. (233 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	DUOX2	DUOX2 isoform 1. (1548 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	PML	PML isoform 6. (836 aa)
	ESRP2	Epithelial splicing regulatory protein 2. (717 aa)
	NTN1	NTN1 isoform 1. (604 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
	HOXB13	HOXB13 isoform 1. (284 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	TBX2	T-box transcription factor 2. (712 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	SLC9A3R1	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
	TWSG1	Twisted gastrulation BMP signaling modulator 1. (223 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	EDAR	Ectodysplasin A receptor. (496 aa)
	HOXD13	HOXD13 isoform 1. (344 aa)
	IGFBP5	Insulin-like growth factor-binding protein 5. (272 aa)
	CUL3	CUL3 isoform 2; Belongs to the cullin family. (768 aa)
	TGM2	Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase). (687 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	LRP5L	LDL receptor related protein 5 like. (252 aa)
	DAG1	Dystroglycan 1 (Dystrophin-associated glycoprotein 1). (895 aa)
	PLXND1	PLXND1 isoform 1. (1925 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	NFKB1	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
	NR3C1	NR3C1 isoform 5. (778 aa)
	LRRC1	Leucine rich repeat containing 1. (524 aa)
	ARG1	Arginase. (322 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	GLI3	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
	SEMA3C	SEMA3C isoform 1; Belongs to the semaphorin family. (751 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	FGL1	Fibrinogen like 1. (312 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
	TNC	TNC isoform 1. (2201 aa)
	NOTCH1	NOTCH1 isoform 1. (2555 aa)
	EDA	Ectodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
	RXFP1	RXFP1 isoform 5. (779 aa)
	HOXA13-2	HOXA13 isoform 1. (388 aa)
	SERPINB5	Serpin family B member 5; Belongs to the serpin family. (375 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	MST1	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
	CSMD2	CUB and Sushi multiple domains 2. (3631 aa)
	SFRP1	Secreted frizzled-related protein 1. (314 aa)
	CRIP1	Cysteine-rich protein 1 (Intestinal). (77 aa)
	NFIB	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
	AREG	AREG isoform 2. (274 aa)
	SCRIB	SCRIB isoform 8. (959 aa)
	ENSPTRP00000062206	annotation not available (69 aa)
	FOXA1	FOXA1 isoform 1. (471 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	HOXA13	Homeobox A13. (388 aa)
	CYP7B1	Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (506 aa)
	PAX6	PAX6 isoform 13. (436 aa)
	CSMD1	CSMD1 isoform 2. (3565 aa)
	SOSTDC1	Sclerostin domain containing 1. (230 aa)
	CAPN1	Calpain 1, (Mu/I) large subunit; Belongs to the peptidase C2 family. (733 aa)
	IL6	Interleukin 6 (Interferon, beta 2). (234 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
	DDR1	Epithelial discoidin domain-containing receptor 1; Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Promotes sm [...] (920 aa)
	EGFR	Receptor protein-tyrosine kinase. (1210 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (585 aa)
	NRG3	NRG3 isoform 3. (721 aa)
	ID4	Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein. (161 aa)
	NKX2-3	NKX2-3 isoform 1. (366 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	KDM5B	KDM5B isoform 2. (1580 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	AR	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
	ELF3	E74 like ETS transcription factor 3. (375 aa)
	TGFA	TGFA isoform 6. (193 aa)
	LOC100615440	Moesin pseudogene. (516 aa)
	IL6-2	Interleukin 6. (234 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	CSF1R	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
	NKX3-1	NKX3-1 isoform 1. (234 aa)
	FEM1B	FEM1B isoform 1. (627 aa)
	SELENOH	Selenoprotein H. (121 aa)
	RARG	Retinoic acid receptor, gamma. (456 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	VDR	Vitamin D (1,25-dihydroxyvitamin D3) receptor. (477 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	LAMA1	Laminin subunit alpha 1. (3104 aa)
	CEBPB	CCAAT/enhancer-binding protein. (347 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	MSN	MSN isoform 1. (577 aa)
	PTCH1	PTCH1 isoform 8. (1428 aa)
	MMP2	Matrix metallopeptidase 2. (660 aa)
	PLXNA1	PLXNA1 isoform 1. (1915 aa)
	SOSTDC1-2	Sclerostin domain containing 1. (206 aa)
	LAMA5	Laminin, alpha 5. (2203 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (521 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (744 aa)
	PHB2	Prohibitin. (299 aa)
	CCL11	C-C motif chemokine. (97 aa)
	SCRIB-2	Scribbled homolog. (1662 aa)
	PLAG1	PLAG1 zinc finger. (500 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	BCL2	ENSPTRP00000076864	ENSPTRP00000090293	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	BCL2 apoptosis regulator.	0.509
AR	CEBPB	ENSPTRP00000076864	ENSPTRP00000085781	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	CCAAT/enhancer-binding protein.	0.455
AR	EGFR	ENSPTRP00000076864	ENSPTRP00000069741	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Receptor protein-tyrosine kinase.	0.710
AR	ESR1	ENSPTRP00000076864	ENSPTRP00000031932	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.841
AR	FOXA1	ENSPTRP00000076864	ENSPTRP00000062658	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	FOXA1 isoform 1.	0.959
AR	HOXB13	ENSPTRP00000076864	ENSPTRP00000015908	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	HOXB13 isoform 1.	0.678
AR	KDM5B	ENSPTRP00000076864	ENSPTRP00000075701	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	KDM5B isoform 2.	0.591
AR	MED1	ENSPTRP00000076864	ENSPTRP00000015490	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.638
AR	NKX3-1	ENSPTRP00000076864	ENSPTRP00000081164	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	NKX3-1 isoform 1.	0.726
AR	NR3C1	ENSPTRP00000076864	ENSPTRP00000029679	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	NR3C1 isoform 5.	0.701
AR	PGR	ENSPTRP00000076864	ENSPTRP00000007237	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.	0.715
AR	PHB2	ENSPTRP00000076864	ENSPTRP00000091437	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Prohibitin.	0.512
AR	SOX9	ENSPTRP00000076864	ENSPTRP00000016293	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.412
AR	SRC	ENSPTRP00000076864	ENSPTRP00000076797	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Tyrosine-protein kinase.	0.911
AREG	CCL11	ENSPTRP00000061353	ENSPTRP00000093089	AREG isoform 2.	C-C motif chemokine.	0.427
AREG	CSF1R	ENSPTRP00000061353	ENSPTRP00000080883	AREG isoform 2.	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.675
AREG	EGFR	ENSPTRP00000061353	ENSPTRP00000069741	AREG isoform 2.	Receptor protein-tyrosine kinase.	0.997
AREG	EPHA2	ENSPTRP00000061353	ENSPTRP00000000400	AREG isoform 2.	EPH receptor A2.	0.703
AREG	ESR1	ENSPTRP00000061353	ENSPTRP00000031932	AREG isoform 2.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.509
AREG	FGF7	ENSPTRP00000061353	ENSPTRP00000012061	AREG isoform 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.528