STRINGSTRING
KCNH2 KCNH2 MYO1F MYO1F CACNA1D CACNA1D NUP155 NUP155 MYH9 MYH9 MYO1G-2 MYO1G-2 MYO5A MYO5A ENSPTRP00000080129 ENSPTRP00000080129 ACTN4 ACTN4 MYH7 MYH7 MYO1B MYO1B ABCC9 ABCC9 PIK3CA PIK3CA ROCK1 ROCK1 ENSPTRP00000086934 ENSPTRP00000086934 KCNQ1 KCNQ1 MYO1H MYO1H CAMK2D CAMK2D MYH6 MYH6 MYL6 MYL6 SCN1B SCN1B PARVA PARVA FGF12 FGF12 MYO1C MYO1C ATP1A1 ATP1A1 EMP2 EMP2 SCN4B SCN4B WAS-2 WAS-2 ENSPTRP00000091918 ENSPTRP00000091918 MYO15B MYO15B ENSPTRP00000092784 ENSPTRP00000092784 MYO1D MYO1D LOC468314 LOC468314 KCNJ5 KCNJ5 MYO7A MYO7A WIPF1 WIPF1 SCN2B SCN2B MYH3 MYH3 CACNA2D1 CACNA2D1 TNNT2 TNNT2 MYO6 MYO6 GPD1L GPD1L SCN5A SCN5A MYH10 MYH10 ENSPTRP00000068927 ENSPTRP00000068927 WAS WAS SYNE2 SYNE2 ENSPTRP00000067778 ENSPTRP00000067778 FRMD6 FRMD6 SLC9A1 SLC9A1 FNBP1L FNBP1L LOC736481 LOC736481 CACNA1G CACNA1G MYH14 MYH14 ENSPTRP00000064617 ENSPTRP00000064617 RYR2 RYR2 WIPF2 WIPF2 NEDD4L NEDD4L LIMCH1 LIMCH1 EPB41L5 EPB41L5 MYO9B MYO9B KCNE3 KCNE3 KCND3 KCND3 KCNE5 KCNE5 SGCD SGCD SHTN1 SHTN1 KCNE2 KCNE2 MYH4 MYH4 PDPN PDPN WASF2 WASF2 ENSPTRP00000000715 ENSPTRP00000000715 SCN3B SCN3B CACNA1C CACNA1C KCNA5 KCNA5 KCNJ8 KCNJ8 PKP2 PKP2 MYO1A MYO1A CCDC88C CCDC88C MYO5C MYO5C MYO1E MYO1E MYLPF MYLPF MYH1 MYH1 MYH2 MYH2 MYO15A MYO15A MYO19 MYO19 KCNJ2 KCNJ2 MYO5B MYO5B MYO7B MYO7B KCNJ3 KCNJ3 SCN1A SCN1A MYL1 MYL1 VIL1 VIL1 KCNE4 KCNE4 SNTA1 SNTA1 KCNE1 KCNE1 CAV3 CAV3 KCNN2 KCNN2 WIPF3 WIPF3 EPDR1 EPDR1 WASL WASL GSN GSN TPM1 TPM1 MYO1G MYO1G CACNB2 CACNB2 ANK2 ANK2 SUN2 SUN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNH2Potassium voltage-gated channel subfamily H member 2. (1159 aa)
MYO1FMYO1F isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (988 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
NUP155Nucleoporin 155kDa. (1391 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
MYO1G-2Myosin IG. (1018 aa)
MYO5AMYO5A isoform 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1877 aa)
ENSPTRP00000080129annotation not available (416 aa)
ACTN4Actinin, alpha 4. (931 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
MYO1BMYO1B isoform 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1136 aa)
ABCC9ATP-binding cassette, sub-family C (CFTR/MRP), member 9. (1549 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
ENSPTRP00000086934annotation not available (467 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
MYO1HMYO1H isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1038 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (446 aa)
MYH6MYH6 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2050 aa)
MYL6MYL6 isoform 8. (233 aa)
SCN1BSodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. (268 aa)
PARVAPARVA isoform 1. (412 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
MYO1CMYO1C isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation. Facilitates surface trafficking and the formation of lipid rafts bearing GPI-anchor proteins. Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T- cell mediated cytotoxicity. R [...] (167 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (228 aa)
WAS-2WASP actin nucleation promoting factor. (502 aa)
ENSPTRP00000091918annotation not available (454 aa)
MYO15BMYO15B isoform 5; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3036 aa)
ENSPTRP00000092784annotation not available (75 aa)
MYO1DMYO1D isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1006 aa)
LOC468314MYL6 isoform 18. (116 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
MYO7AMYO7A isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2222 aa)
WIPF1WAS/WASL interacting protein family, member 1. (554 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (215 aa)
MYH3Myosin, heavy chain 3, skeletal muscle, embryonic; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1940 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
TNNT2Troponin T type 2 (Cardiac). (298 aa)
MYO6MYO6 isoform 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1290 aa)
GPD1LGlycerol-3-phosphate dehydrogenase [NAD(+)]. (351 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
ENSPTRP00000068927annotation not available (480 aa)
WASWAS isoform 1. (502 aa)
SYNE2SYNE2 isoform 1. (6907 aa)
ENSPTRP00000067778annotation not available (85 aa)
FRMD6FERM domain containing 6. (622 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
FNBP1LFormin binding protein 1 like. (611 aa)
LOC736481Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (400 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2036 aa)
ENSPTRP00000064617annotation not available (92 aa)
RYR2RYR2 isoform 1. (4941 aa)
WIPF2WAS/WASL interacting protein family, member 2. (440 aa)
NEDD4LNEDD4L isoform 6. (1254 aa)
LIMCH1LIM and calponin homology domains 1. (1626 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (733 aa)
MYO9BLOW QUALITY PROTEIN: unconventional myosin-IXb. (1987 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (103 aa)
KCND3Potassium voltage-gated channel, Shal-related subfamily, member 3; Belongs to the potassium channel family. (655 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (142 aa)
SGCDSarcoglycan, delta (35kDa dystrophin-associated glycoprotein). (290 aa)
SHTN1SHTN1 isoform 3. (636 aa)
KCNE2KCNE2 isoform 1. (123 aa)
MYH4Myosin heavy chain 4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
PDPNPDPN isoform 3. (238 aa)
WASF2WAS protein family, member 2. (498 aa)
ENSPTRP00000000715Wiskott-Aldrich syndrome protein family member 2-like. (492 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (215 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (602 aa)
KCNJ8Potassium inwardly-rectifying channel, subfamily J, member 8. (424 aa)
PKP2PKP2 isoform 1. (837 aa)
MYO1AMYO1A isoform 4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1043 aa)
CCDC88CCCDC88C isoform 3. (2028 aa)
MYO5CMYO5C isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1742 aa)
MYO1EMYO1E isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1108 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (169 aa)
MYH1MYH8 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
MYH2MYH2 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1941 aa)
MYO15AMyosin XVA. (3517 aa)
MYO19MYO19 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (970 aa)
KCNJ2Potassium inwardly-rectifying channel, subfamily J, member 2. (427 aa)
MYO5BT0040421 isoform 1. (1849 aa)
MYO7BMYO7B isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2116 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2009 aa)
MYL1Myosin light chain 1. (192 aa)
VIL1VIL1 isoform 1. (827 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (221 aa)
SNTA1Syntrophin, alpha 1 (Dystrophin-associated protein A1, 59kDa, acidic component). (505 aa)
KCNE1KCNE1B isoform 1. (132 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
KCNN2Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2. (843 aa)
WIPF3WAS/WASL interacting protein family member 3. (483 aa)
EPDR1Ependymin related protein 1 (Zebrafish). (331 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
GSNGSN isoform 3. (782 aa)
TPM1TPM1 isoform 3; Belongs to the tropomyosin family. (326 aa)
MYO1GMYO1G isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1018 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
ANK2ANK2 isoform 1. (3957 aa)
SUN2Sad1 and UNC84 domain containing 2. (717 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (16%) [HD]