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GAD1 GAD1 ENSPTRP00000071311 ENSPTRP00000071311 PDXDC1 PDXDC1 SGPL1 SGPL1 NFS1-2 NFS1-2 KYNU KYNU PHYKPL PHYKPL ENSPTRP00000066534 ENSPTRP00000066534 ENSPTRP00000065447 ENSPTRP00000065447 PYGL PYGL KYAT1 KYAT1 NFS1 NFS1 SHMT2 SHMT2 CK820_G0055659 CK820_G0055659 SPTLC3 SPTLC3 ALB ALB GCAT GCAT GADL1 GADL1 GOT1L1 GOT1L1 ENSPTRP00000092702 ENSPTRP00000092702 ENSPTRP00000092611 ENSPTRP00000092611 GAD2 GAD2 DDC DDC ENSPTRP00000089325 ENSPTRP00000089325 PDXK PDXK CSAD CSAD LOC736372 LOC736372 ENSPTRP00000082047 ENSPTRP00000082047 CK820_G0027673 CK820_G0027673 SPTLC1 SPTLC1 ALAS2 ALAS2 SHMT1 SHMT1 PYGB PYGB CK820_G0055659-2 CK820_G0055659-2 CTH CTH KYAT3 KYAT3 MARC2 MARC2 MARC1 MARC1 GOT1 GOT1 OAT OAT PYGM PYGM SDS SDS THNSL2 THNSL2 SDSL SDSL ISM2 ISM2 SPTLC2 SPTLC2 HDC HDC ABAT ABAT GPT2 GPT2 GOT2 GOT2 TAT TAT SRR SRR PNPO PNPO MOCOS MOCOS GLDC GLDC ACCSL ACCSL GPT GPT PSAT1 PSAT1 PLPBP PLPBP AGXT2 AGXT2 AADAT AADAT ETNPPL ETNPPL ALAS1 ALAS1 CBS CBS ISM1 ISM1 AGXT AGXT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAD1Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. (594 aa)
ENSPTRP00000071311annotation not available (380 aa)
PDXDC1PDXDC1 isoform 10. (809 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
NFS1-2NFS1 cysteine desulfurase. (605 aa)
KYNUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (465 aa)
PHYKPLAlanine-glyoxylate aminotransferase 2-like 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (450 aa)
ENSPTRP00000066534annotation not available (384 aa)
ENSPTRP00000065447annotation not available (354 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (848 aa)
KYAT1Kynurenine aminotransferase 1. (516 aa)
NFS1NFS1 nitrogen fixation 1 homolog. (605 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
CK820_G0055659PDXDC1 isoform 1. (783 aa)
SPTLC3Serine palmitoyltransferase, long chain base subunit 3. (552 aa)
ALBALB isoform 2. (609 aa)
GCATGlycine C-acetyltransferase. (445 aa)
GADL1Glutamate decarboxylase like 1. (521 aa)
GOT1L1GOT1L1 isoform 1. (415 aa)
ENSPTRP00000092702annotation not available (482 aa)
ENSPTRP00000092611annotation not available (106 aa)
GAD2Glutamate decarboxylase 2. (585 aa)
DDCDopa decarboxylase. (489 aa)
ENSPTRP00000089325annotation not available (471 aa)
PDXKPyridoxal (Pyridoxine, vitamin B6) kinase. (309 aa)
CSADCysteine sulfinic acid decarboxylase. (520 aa)
LOC736372Glycine dehydrogenase (decarboxylating), mitochondrial pseudogene. (980 aa)
ENSPTRP00000082047annotation not available (353 aa)
CK820_G0027673GCAT isoform 4. (82 aa)
SPTLC1Aminotran_1_2 domain-containing protein. (463 aa)
ALAS25-aminolevulinate synthase. (587 aa)
SHMT1Serine hydroxymethyltransferase 1. (483 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
CK820_G0055659-2PDXDC1 isoform 13. (80 aa)
CTHCystathionase (Cystathionine gamma-lyase). (405 aa)
KYAT3Cysteine conjugate-beta lyase 2. (454 aa)
MARC2MARC2 isoform 1. (335 aa)
MARC1MOCO sulfurase C-terminal domain containing 1. (337 aa)
GOT1Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (413 aa)
OATOrnithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
SDSSerine dehydratase. (328 aa)
THNSL2Threonine synthase-like 2. (484 aa)
SDSLSerine dehydratase-like. (329 aa)
ISM2ISM2 isoform 4. (567 aa)
SPTLC2Serine palmitoyltransferase, long chain base subunit 2. (564 aa)
HDCHistidine decarboxylase. (662 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (515 aa)
GPT2Glutamic pyruvate transaminase (Alanine aminotransferase) 2. (523 aa)
GOT2Aspartate aminotransferase. (430 aa)
TATTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa)
SRRSerine racemase. (340 aa)
PNPOPyridoxamine 5'-phosphate oxidase. (261 aa)
MOCOSMolybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (888 aa)
GLDCGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1020 aa)
ACCSL1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like. (568 aa)
GPTGlutamic--pyruvic transaminase. (496 aa)
PSAT1Phosphoserine aminotransferase. (370 aa)
PLPBPPyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (275 aa)
AGXT2Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (514 aa)
AADATAminoadipate aminotransferase. (425 aa)
ETNPPLEthanolamine-phosphate phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (499 aa)
ALAS15-aminolevulinate synthase. (640 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (551 aa)
ISM1Isthmin 1 homolog (Zebrafish). (470 aa)
AGXTSerine--pyruvate aminotransferase. (367 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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