STRINGSTRING
RBPJ RBPJ MADCAM1 MADCAM1 CYP26B1 CYP26B1 ENSPTRP00000081042 ENSPTRP00000081042 ENSPTRP00000082912 ENSPTRP00000082912 ENSPTRP00000083068 ENSPTRP00000083068 PALLD PALLD FOSL2 FOSL2 WNT5A WNT5A ENSPTRP00000087057 ENSPTRP00000087057 KRT78 KRT78 BCR BCR NOTCH1 NOTCH1 ENSPTRP00000036205 ENSPTRP00000036205 IFT74 IFT74 PLEC PLEC WNT16 WNT16 LATS1 LATS1 DSP DSP INTU INTU EREG EREG TP63 TP63 CSTA CSTA KRTAP6-1 KRTAP6-1 JAG1 JAG1 ABCA12 ABCA12 IL1A IL1A KLK5 KLK5 CNFN CNFN ACER1 ACER1 EVPL EVPL KRT10 KRT10 MED1 MED1 FOXN1 FOXN1 KRT16 KRT16 CDH3 CDH3 PPL PPL DNASE1L2 DNASE1L2 DSG4 DSG4 S100A7L2 S100A7L2 KRT1 KRT1 ANXA1 ANXA1 KRT81 KRT81 LIPN LIPN LIPK LIPK IVL IVL FLG FLG MAFB MAFB BCL11B BCL11B POU3F1 POU3F1 KRTAP6-2 KRTAP6-2 CK820_G0018145 CK820_G0018145 CASP3 CASP3 KRT2 KRT2 SFN SFN KAZN KAZN PNPLA1 PNPLA1 CERS3 CERS3 SHARPIN SHARPIN LOC451917 LOC451917 LCE6A LCE6A CASP14 CASP14 KRT74 KRT74 TSG101 TSG101 STK4 STK4 ENSPTRP00000063255 ENSPTRP00000063255 LOC738608 LOC738608 ASAH1 ASAH1 SPRR2B SPRR2B UGCG UGCG PAX6 PAX6 LOC452254 LOC452254 LOC457411 LOC457411 PPP3CA PPP3CA EXPH5 EXPH5 S100A7A S100A7A KRT83 KRT83 ENSPTRP00000069368 ENSPTRP00000069368 LCE3E LCE3E KRT75 KRT75 PIP5K1A PIP5K1A ENSPTRP00000075125 ENSPTRP00000075125 PPHLN1 PPHLN1 HRNR HRNR S100A7 S100A7 KRT80 KRT80 ENSPTRP00000076491 ENSPTRP00000076491 EZH2 EZH2 LOC738560 LOC738560 AKR1C3 AKR1C3 TCHH TCHH SAV1 SAV1 TGM1 TGM1 LATS2 LATS2 KRT79 KRT79 KRT4 KRT4 KRT76 KRT76 KRT77 KRT77 KRT73 KRT73 KRT72 KRT72 KRT71 KRT71 KRT5 KRT5 KRT82 KRT82 KRT84 KRT84 KRT85 KRT85 CK820_G0039600 CK820_G0039600 YAP1 YAP1 LIPM LIPM OPN3 OPN3 TMEM79 TMEM79 SPRR3 SPRR3 LCE1A LCE1A LCE3A LCE3A LCE3B LCE3B LCE3C LCE3C LCE5A LCE5A TXNIP TXNIP KDF1 KDF1 CLIC4 CLIC4 EPHA2 EPHA2 PIPSL PIPSL ENSPTRP00000088411 ENSPTRP00000088411 SPRR2G SPRR2G FLNB FLNB KRT8 KRT8 ENSPTRP00000089841 ENSPTRP00000089841 EZH2-2 EZH2-2 ST14 ST14 KRT7 KRT7 IRF6 IRF6 ADAM9 ADAM9 KRT3 KRT3 LCE3D LCE3D SCEL SCEL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
MADCAM1MADCAM1 isoform 9. (414 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
ENSPTRP00000081042annotation not available (262 aa)
ENSPTRP00000082912annotation not available (153 aa)
ENSPTRP00000083068annotation not available (421 aa)
PALLDPalladin, cytoskeletal associated protein. (1123 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ENSPTRP00000087057annotation not available (440 aa)
KRT78KRT78 isoform 2; Belongs to the intermediate filament family. (520 aa)
BCRBCR activator of RhoGEF and GTPase. (1271 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ENSPTRP00000036205Keratin, type II cytoskeletal 8-like. (478 aa)
IFT74Intraflagellar transport 74 homolog. (600 aa)
PLECPLEC isoform 2. (4684 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
LATS1LATS, large tumor suppressor, homolog 1. (1130 aa)
DSPDSP isoform 1. (2871 aa)
INTUInturned planar cell polarity effector homolog. (911 aa)
EREGEREG isoform 1. (169 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
CSTACystatin A (Stefin A); Belongs to the cystatin family. (98 aa)
KRTAP6-1Keratin associated protein 6-1. (71 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
ABCA12ATP binding cassette subfamily A member 12. (2595 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
KLK5Kallikrein related peptidase 5; Belongs to the peptidase S1 family. (293 aa)
CNFNCNFN isoform 1. (125 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
EVPLEVPL isoform 2. (2055 aa)
KRT10KRT10 isoform 1; Belongs to the intermediate filament family. (577 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
FOXN1FOXN1 isoform 2. (648 aa)
KRT16KRT16 isoform 4; Belongs to the intermediate filament family. (485 aa)
CDH3Cadherin 3, type 1, P-cadherin (Placental); Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
PPLPPL isoform 2. (1756 aa)
DNASE1L2Deoxyribonuclease; Belongs to the DNase I family. (299 aa)
DSG4DSG4 isoform 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1059 aa)
S100A7L2S100 calcium binding protein A7 like 2. (112 aa)
KRT1Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta 1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity). (642 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa)
KRT81KRT81 isoform 1; Belongs to the intermediate filament family. (506 aa)
LIPNLipase; Belongs to the AB hydrolase superfamily. Lipase family. (398 aa)
LIPKLipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
IVLInvolucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. (554 aa)
FLGFLG isoform 1. (3364 aa)
MAFBV-maf musculoaponeurotic fibrosarcoma oncogene homolog B (Avian). (323 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (894 aa)
POU3F1POU domain protein. (451 aa)
KRTAP6-2Keratin associated protein 6-2. (62 aa)
CK820_G0018145KRTAP6-3 isoform 1. (93 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
KRT2KRT2 isoform 1; Belongs to the intermediate filament family. (645 aa)
SFNSFN isoform 1; Belongs to the 14-3-3 family. (248 aa)
KAZNKazrin, periplakin interacting protein. (863 aa)
PNPLA1Patatin like phospholipase domain containing 1. (533 aa)
CERS3CERS3 isoform 1. (383 aa)
SHARPINSHANK-associated RH domain interactor. (387 aa)
LOC451917Keratin, type II cuticular Hb1-like. (462 aa)
LCE6ALate cornified envelope 6A. (80 aa)
CASP14CASP14 isoform 1; Belongs to the peptidase C14A family. (242 aa)
KRT74KRT74 isoform 2; Belongs to the intermediate filament family. (543 aa)
TSG101Tumor susceptibility 101. (405 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
ENSPTRP00000063255annotation not available (394 aa)
LOC738608KRT6B isoform 1; Belongs to the intermediate filament family. (564 aa)
ASAH1Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] (411 aa)
SPRR2BSmall proline-rich protein 2A. (72 aa)
UGCGUDP-glucose ceramide glucosyltransferase. (394 aa)
PAX6PAX6 isoform 13. (436 aa)
LOC452254LOW QUALITY PROTEIN: disintegrin and metalloproteinase domain-containing protein 1-like. (863 aa)
LOC457411Keratin, type II cytoskeletal 8 pseudogene. (503 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
EXPH5EXPH5 isoform 2. (1988 aa)
S100A7AProtein S100; Belongs to the S-100 family. (101 aa)
KRT83Keratin, type II cuticular Hb3. (501 aa)
ENSPTRP00000069368annotation not available (459 aa)
LCE3ELate cornified envelope 3E. (92 aa)
KRT75KRT75 isoform 1; Belongs to the intermediate filament family. (551 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
ENSPTRP00000075125annotation not available (537 aa)
PPHLN1PPHLN1 isoform 4. (458 aa)
HRNRHRNR isoform 1. (2233 aa)
S100A7Protein S100; Belongs to the S-100 family. (101 aa)
KRT80KRT80 isoform 1; Belongs to the intermediate filament family. (497 aa)
ENSPTRP00000076491annotation not available (91 aa)
EZH2Enhancer of zeste homolog 2. (754 aa)
LOC738560Keratin, type II cytoskeletal 6B. (472 aa)
AKR1C3Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). (323 aa)
TCHHTCHH isoform 1. (1384 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
TGM1TGM1 isoform 1. (818 aa)
LATS2Non-specific serine/threonine protein kinase. (1088 aa)
KRT79KRT79 isoform 1; Belongs to the intermediate filament family. (643 aa)
KRT4KRT4 isoform 1; Belongs to the intermediate filament family. (608 aa)
KRT76KRT76 isoform 1; Belongs to the intermediate filament family. (640 aa)
KRT77KRT77 isoform 2; Belongs to the intermediate filament family. (583 aa)
KRT73KRT73 isoform 1; Belongs to the intermediate filament family. (540 aa)
KRT72KRT72 isoform 2; Belongs to the intermediate filament family. (511 aa)
KRT71KRT71 isoform 1; Belongs to the intermediate filament family. (523 aa)
KRT5Keratin, type II cytoskeletal 5; Belongs to the intermediate filament family. (592 aa)
KRT82KRT82 isoform 1; Belongs to the intermediate filament family. (513 aa)
KRT84KRT84 isoform 1; Belongs to the intermediate filament family. (600 aa)
KRT85KRT85 isoform 1; Belongs to the intermediate filament family. (507 aa)
CK820_G0039600KRT86 isoform 1; Belongs to the intermediate filament family. (469 aa)
YAP1Yes-associated protein 1. (508 aa)
LIPMLipase; Belongs to the AB hydrolase superfamily. Lipase family. (423 aa)
OPN3CHML isoform 2. (402 aa)
TMEM79Transmembrane protein 79. (394 aa)
SPRR3Small proline rich protein 3. (161 aa)
LCE1ALate cornified envelope 1A. (110 aa)
LCE3ALate cornified envelope 3A. (89 aa)
LCE3BLCE3B isoform 1. (95 aa)
LCE3CLate cornified envelope 3C. (94 aa)
LCE5ALCE5A isoform 1. (118 aa)
TXNIPArrestin_C domain-containing protein. (391 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
EPHA2EPH receptor A2. (976 aa)
PIPSLPIP5K1A and PSMD4-like. (548 aa)
ENSPTRP00000088411annotation not available (465 aa)
SPRR2GSmall proline rich protein 2G. (73 aa)
FLNBFilamin B, beta. (2633 aa)
KRT8KRT8 isoform 11; Belongs to the intermediate filament family. (483 aa)
ENSPTRP00000089841annotation not available (259 aa)
EZH2-2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (862 aa)
KRT7Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells; Belongs to the intermediate filament family. (469 aa)
IRF6Interferon regulatory factor 6. (467 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
KRT3KRT3 isoform 1; Belongs to the intermediate filament family. (629 aa)
LCE3DLate cornified envelope 3D. (92 aa)
SCELSCEL isoform 3. (688 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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