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| | PREX1 | Phosphatidylinositol-3,4, 5-trisphosphate-dependent Rac exchange factor 1. (1659 aa) |
| | LFNG | LFNG isoform 5. (405 aa) |
| | RORC | RAR related orphan receptor C. (525 aa) |
| | SPI1 | Spi-1 proto-oncogene. (270 aa) |
| | XRCC4 | X-ray repair complementing defective repair in Chinese hamster cells 4. (334 aa) |
| | EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa) |
| | CARD11 | Caspase recruitment domain family, member 11. (1154 aa) |
| | SP3 | Sp3 transcription factor. (781 aa) |
| | ENTPD7 | Ectonucleoside triphosphate diphosphohydrolase 7; Belongs to the GDA1/CD39 NTPase family. (605 aa) |
| | RORA | RAR-related orphan receptor A. (555 aa) |
| | FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa) |
| | RELB | RELB isoform 3. (567 aa) |
| | ENSPTRP00000088670 | annotation not available (116 aa) |
| | ENSPTRP00000088742 | annotation not available (116 aa) |
| | STAT5B | Signal transducer and activator of transcription. (772 aa) |
| | BRAF-2 | BRAF isoform 2. (766 aa) |
| | LOC473484 | Cathepsin L1. (276 aa) |
| | BCL2 | BCL2 apoptosis regulator. (239 aa) |
| | ENSPTRP00000090382 | annotation not available (493 aa) |
| | MR1 | Major histocompatibility complex class I-related gene protein; Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T- cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent (By similarity); Belongs to the MHC [...] (341 aa) |
| | STAT3 | Signal transducer and activator of transcription. (790 aa) |
| | RHOH | RHOH isoform 10. (191 aa) |
| | THEMIS | Thymocyte selection associated. (680 aa) |
| | ENSPTRP00000092837 | annotation not available (325 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1255 aa) |
| | ENSPTRP00000069560 | annotation not available (214 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa) |
| | SEMA4A | SEMA4A isoform 10; Belongs to the semaphorin family. (761 aa) |
| | FUT7 | Fucosyltransferase 7. (342 aa) |
| | IL6 | Interleukin 6 (Interferon, beta 2). (234 aa) |
| | BCL6 | BCL6 transcription repressor. (706 aa) |
| | IL15 | Interleukin; Belongs to the IL-15/IL-21 family. (162 aa) |
| | DNAJA3 | DnaJ heat shock protein family (Hsp40) member A3. (480 aa) |
| | CD8A | CD8A isoform 1. (235 aa) |
| | SPN-2 | SPN isoform 1. (418 aa) |
| | ZFP36L2 | Zinc finger protein 36, C3H type-like 2. (492 aa) |
| | ENSPTRP00000066621 | annotation not available (709 aa) |
| | RUNX2 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (526 aa) |
| | GATA3 | GATA binding protein 3. (444 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (955 aa) |
| | ATP7A | ATPase, Cu++ transporting, alpha polypeptide. (1500 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | TSC1 | TSC complex subunit 1. (1164 aa) |
| | WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | ENSPTRP00000062821 | annotation not available (220 aa) |
| | CK820_G0012168 | ABL1 isoform 3. (1149 aa) |
| | ZFP36L1 | ZFP36 ring finger protein like 1. (338 aa) |
| | RPS6 | 40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa) |
| | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. (233 aa) |
| | LEPR | Leptin receptor. (1165 aa) |
| | ZBTB1 | Zinc finger and BTB domain containing 1. (676 aa) |
| | NHEJ1 | Non-homologous end joining factor 1. (299 aa) |
| | CD4 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa) |
| | DLL4 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa) |
| | SPN | SPN isoform 3. (400 aa) |
| | ARMC5 | Armadillo repeat containing 5. (1030 aa) |
| | CCR7 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa) |
| | IKZF3 | IKAROS family zinc finger 3. (509 aa) |
| | BCL11B | BAF chromatin remodeling complex subunit BCL11B. (894 aa) |
| | ADAM17 | ADAM17 isoform 3. (999 aa) |
| | MAFB | V-maf musculoaponeurotic fibrosarcoma oncogene homolog B (Avian). (323 aa) |
| | SLAMF6 | SLAM family member 6. (332 aa) |
| | FCER1G | Fc fragment of IgE receptor Ig. (112 aa) |
| | SOX4 | Transcription factor SOX. (474 aa) |
| | ANXA1 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa) |
| | BCL3 | BCL3 transcription coactivator. (454 aa) |
| | CD74 | CD74 isoform 5. (296 aa) |
| | IL2RG | IL2RG isoform 1. (369 aa) |
| | NKAP | NFKB activating protein. (415 aa) |
| | GPR18 | Probable G-protein coupled receptor 18; Belongs to the G-protein coupled receptor 1 family. (331 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic polypeptide; Belongs to the PI3/PI4-kinase family. (4128 aa) |
| | CTNNB1 | Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa) |
| | NRARP | NOTCH regulated ankyrin repeat protein. (114 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | CK820_G0018745 | FZD8 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (628 aa) |
| | SASH3 | SAM and SH3 domain containing 3. (380 aa) |
| | FOXP3 | FOXP3 isoform 4. (456 aa) |
| | RC3H2 | Ring finger and CCCH-type domains 2. (1191 aa) |
| | TNFSF8 | Tumor necrosis factor ligand 3A; Belongs to the tumor necrosis factor family. (234 aa) |
| | CTSL | CTSL isoform 2; Belongs to the peptidase C1 family. (333 aa) |
| | CHD7 | CHD7 isoform 1. (2997 aa) |
| | TOX | Thymocyte selection-associated high mobility group box. (526 aa) |
| | CDK6 | Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | GLI3 | Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa) |
| | TRAF3IP2 | TRAF3 interacting protein 2. (574 aa) |
| | ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa) |
| | SRF | Serum response factor (C-fos serum response element-binding transcription factor). (508 aa) |
| | CD83 | CD83 isoform 2. (205 aa) |
| | IRF4 | Interferon regulatory factor 4. (451 aa) |
| | PRR7 | Proline rich 7 (Synaptic). (274 aa) |
| | DOCK2 | Dedicator of cytokinesis 2; Belongs to the DOCK family. (1830 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa) |
| | ITK | Tyrosine-protein kinase. (620 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. (153 aa) |
| | IRF1 | Interferon regulatory factor. (325 aa) |
| | PTGER4 | Prostaglandin E2 receptor EP4 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function (By similarity). Belongs to the G-protein coupled receptor 1 family. (490 aa) |
| | IL21 | Interleukin; Belongs to the IL-15/IL-21 family. (162 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa) |
| | KIT | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa) |
| | RABL3 | RAB, member of RAS oncogene family-like 3. (236 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | CCR9 | C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (369 aa) |
| | EOMES | EOMES isoform 2. (704 aa) |
| | NCAPH2 | NCAPH2 isoform 1. (606 aa) |
| | PATZ1 | POZ (BTB) and AT hook containing zinc finger 1. (687 aa) |
| | AIRE | Autoimmune regulator. (545 aa) |
| | PAX1 | PAX1 isoform 1. (457 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa) |
| | CD28 | CD28 isoform 3. (220 aa) |
| | IL18R1 | Uncharacterized protein. (440 aa) |
| | ZAP70 | Tyrosine-protein kinase. (619 aa) |
| | RSAD2 | RSAD2 isoform 1. (361 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | PIK3R2 | Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa) |
| | CLEC4G | C-type lectin domain family 4 member G. (293 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (845 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (307 aa) |
| | LFNG-2 | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (242 aa) |
| | JMJD6 | Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (420 aa) |
| | TBX21 | T-box transcription factor 21. (535 aa) |
| | TMEM98 | Transmembrane protein 98. (226 aa) |
| | FOXN1 | FOXN1 isoform 2. (648 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | ZFPM1 | ZFPM1 isoform 1. (974 aa) |
| | IL4R | IL4R isoform 2. (827 aa) |
| | BATF | Basic leucine zipper ATF-like transcription factor. (125 aa) |
| | RIPK3 | Receptor interacting serine/threonine kinase 3. (518 aa) |
| | GPR183 | G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (361 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | TESPA1 | TESPA1 isoform 6. (521 aa) |
| | LMBR1L | Limb development membrane protein 1 like; Belongs to the LIMR family. (489 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | CLEC4E | C-type lectin domain family 4 member E. (219 aa) |
| | CLEC4D | CLEC4D isoform 2. (215 aa) |
| | CRACR2A | CRACR2A isoform 3. (732 aa) |
| | CD3G | CD3G isoform 1. (182 aa) |
| | CD3D | CD3D isoform 1. (171 aa) |
| | IL4-2 | Interleukin 4. (153 aa) |
| | PKNOX1 | PBX/knotted 1 homeobox 1. (436 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa) |
| | PTPN2 | Tyrosine-protein phosphatase non-receptor type. (421 aa) |
| | CD3E | CD3E isoform 2. (207 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | TCIRG1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa) |
| | RAG2 | Recombination activating 2. (527 aa) |
| | ITPKB | Kinase; Belongs to the inositol phosphokinase (IPK) family. (946 aa) |
| | HLX | H2.0-like homeobox. (493 aa) |
| | SOX13 | SRY (Sex determining region Y)-box 13. (622 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1306 aa) |
| | RC3H1 | Ring finger and CCCH-type domains 1. (1134 aa) |
| | LY9 | LY9 isoform 4. (655 aa) |
| | ZBTB7B | Zinc finger and BTB domain containing 7B. (573 aa) |
| | IL6R | Interleukin 6 receptor. (442 aa) |
| | GPR89A | G protein-coupled receptor 89A. (455 aa) |
| | LCK | Tyrosine-protein kinase. (539 aa) |
| | PLA2G2D | Phospholipase A(2). (161 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | RPL22 | Ribosomal protein L22. (128 aa) |
| | ABL1 | Tyrosine-protein kinase. (1149 aa) |
| | ADA | Adenosine deaminase. (412 aa) |
| | ENSPTRP00000074403 | annotation not available (115 aa) |
| | ENSPTRP00000074467 | annotation not available (129 aa) |
| | NKX2-3 | NKX2-3 isoform 1. (366 aa) |
| | SYK | Tyrosine-protein kinase. (635 aa) |
| | FOXP1 | FOXP1 isoform 2. (693 aa) |
| | PTPN22 | Protein tyrosine phosphatase, non-receptor type 22 (Lymphoid). (807 aa) |
| | ENSPTRP00000075447 | annotation not available (88 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa) |
| | IL7R | Interleukin 7 receptor. (459 aa) |
| | JAG2 | Jagged canonical Notch ligand 2. (1130 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa) |
| | ENSPTRP00000077720 | annotation not available (54 aa) |
| | ENSPTRP00000079023 | annotation not available (237 aa) |
| | IL7 | Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (179 aa) |
| | PGBD4 | PiggyBac transposable element derived 4. (585 aa) |
| | BRAF | BRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (414 aa) |
| | IL6-2 | Interleukin 6. (234 aa) |
| | ENSPTRP00000080295 | annotation not available (95 aa) |
| | ENSPTRP00000081143 | annotation not available (219 aa) |
| | TCF7 | Transcription factor 7. (481 aa) |
