(47 nodes) Chromosome condensation network (Pan troglodytes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100612812	LOW QUALITY PROTEIN: spermatid-specific linker histone H1-like protein. (231 aa)
	PRM1	Protamine-2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. (140 aa)
	ERN2	ERN2 isoform 1. (926 aa)
	TOP2A	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa)
	TTN	TTN isoform 3. (32000 aa)
	NCAPH2	NCAPH2 isoform 1. (606 aa)
	H1-10	H1FX isoform 1. (213 aa)
	H1FOO	H1FOO isoform 2. (346 aa)
	NCAPG	Non-SMC condensin I complex, subunit G. (1042 aa)
	TENT4A	PAPD7 isoform 1. (776 aa)
	H1-1	HIST1H1A isoform 1. (215 aa)
	PLK1	Serine/threonine-protein kinase PLK. (621 aa)
	RBM48-2	RBM48 isoform 2. (378 aa)
	HIST1H1C	HIST1H1C isoform 1. (213 aa)
	HIST1H1T	HIST1H1T isoform 1. (209 aa)
	HIST1H1E	Histone cluster 1 H1 family member e. (219 aa)
	CDCA5	CDCA5 isoform 3. (262 aa)
	NCAPG2	Non-SMC condensin II complex subunit G2. (1156 aa)
	BANF2	Barrier-to-autointegration factor-like protein. (97 aa)
	AKAP8	A kinase (PRKA) anchor protein 8; Belongs to the AKAP95 family. (692 aa)
	AKAP8L	A kinase (PRKA) anchor protein 8-like; Belongs to the AKAP95 family. (647 aa)
	CK820_G0045089	RANBP3 isoform 23. (97 aa)
	NCAPH	Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (745 aa)
	HIST1H1D	HIST1H1D isoform 1. (221 aa)
	HIST1H1B	HIST1H1B isoform 1. (226 aa)
	CDK1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	SMC5	Structural maintenance of chromosomes 5. (1101 aa)
	HMGA2	High mobility group AT-hook 2. (147 aa)
	H1-0	H1F0 isoform 1. (194 aa)
	DFFB	DNAation factor, 40kDa, beta polypeptide (Caspase-activated DNase). (338 aa)
	NCAPD2	Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1401 aa)
	RBM48	Chromosome 7 open reading frame 64. (369 aa)
	SETD8	SET domain containing (Lysine methyltransferase) 8. (334 aa)
	KMT5A	[histone H4]-lysine20 N-methyltransferase SETD8. (199 aa)
	ENSPTRP00000069326	annotation not available (317 aa)
	AIFM1	Apoptosis-inducing factor, mitochondrion-associated, 1. (603 aa)
	ENSPTRP00000073552	annotation not available (162 aa)
	ENSPTRP00000074041	annotation not available (223 aa)
	SMC2	Structural maintenance of chromosomes protein. (1197 aa)
	SMC4	Structural maintenance of chromosomes protein. (1288 aa)
	BANF1	Barrier to autointegration factor 1. (89 aa)
	PHF13	PHD finger protein 13. (300 aa)
	ENSPTRP00000006737	Barrier to autointegration factor 1. (89 aa)
	NCAPD3	Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. (1498 aa)
	H1-7	H1FNT isoform 1. (255 aa)
	ACIN1	ACIN1 isoform 7. (1342 aa)
	NUSAP1	Nucleolar and spindle associated protein 1. (440 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACIN1	DFFB	ENSPTRP00000010442	ENSPTRP00000064348	ACIN1 isoform 7.	DNAation factor, 40kDa, beta polypeptide (Caspase-activated DNase).	0.674
AKAP8	AKAP8L	ENSPTRP00000083023	ENSPTRP00000083207	A kinase (PRKA) anchor protein 8; Belongs to the AKAP95 family.	A kinase (PRKA) anchor protein 8-like; Belongs to the AKAP95 family.	0.480
AKAP8L	AKAP8	ENSPTRP00000083207	ENSPTRP00000083023	A kinase (PRKA) anchor protein 8-like; Belongs to the AKAP95 family.	A kinase (PRKA) anchor protein 8; Belongs to the AKAP95 family.	0.480
BANF1	H1-0	ENSPTRP00000079424	ENSPTRP00000061378	Barrier to autointegration factor 1.	H1F0 isoform 1.	0.403
CDCA5	CDK1	ENSPTRP00000082305	ENSPTRP00000050657	CDCA5 isoform 3.	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.881
CDCA5	ENSPTRP00000074041	ENSPTRP00000082305	ENSPTRP00000074041	CDCA5 isoform 3.	annotation not available	0.496
CDCA5	NCAPD2	ENSPTRP00000082305	ENSPTRP00000065120	CDCA5 isoform 3.	Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.	0.488
CDCA5	NCAPG	ENSPTRP00000082305	ENSPTRP00000027454	CDCA5 isoform 3.	Non-SMC condensin I complex, subunit G.	0.866
CDCA5	NCAPG2	ENSPTRP00000082305	ENSPTRP00000083020	CDCA5 isoform 3.	Non-SMC condensin II complex subunit G2.	0.571
CDCA5	NCAPH	ENSPTRP00000082305	ENSPTRP00000089623	CDCA5 isoform 3.	Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.	0.758
CDCA5	NUSAP1	ENSPTRP00000082305	ENSPTRP00000011847	CDCA5 isoform 3.	Nucleolar and spindle associated protein 1.	0.775
CDCA5	PHF13	ENSPTRP00000082305	ENSPTRP00000000180	CDCA5 isoform 3.	PHD finger protein 13.	0.494
CDCA5	PLK1	ENSPTRP00000082305	ENSPTRP00000093799	CDCA5 isoform 3.	Serine/threonine-protein kinase PLK.	0.672
CDCA5	SMC2	ENSPTRP00000082305	ENSPTRP00000075528	CDCA5 isoform 3.	Structural maintenance of chromosomes protein.	0.617
CDCA5	SMC4	ENSPTRP00000082305	ENSPTRP00000076324	CDCA5 isoform 3.	Structural maintenance of chromosomes protein.	0.599
CDCA5	SMC5	ENSPTRP00000082305	ENSPTRP00000042849	CDCA5 isoform 3.	Structural maintenance of chromosomes 5.	0.653
CDCA5	TOP2A	ENSPTRP00000082305	ENSPTRP00000015554	CDCA5 isoform 3.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.883
CDK1	CDCA5	ENSPTRP00000050657	ENSPTRP00000082305	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	CDCA5 isoform 3.	0.881
CDK1	ENSPTRP00000074041	ENSPTRP00000050657	ENSPTRP00000074041	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	annotation not available	0.917
CDK1	H1-0	ENSPTRP00000050657	ENSPTRP00000061378	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	H1F0 isoform 1.	0.793