STRINGSTRING
ACTN3 ACTN3 WNT5A WNT5A ANKH ANKH GATA1 GATA1 TFAP2A TFAP2A BCL2 BCL2 MEF2C MEF2C MGP MGP SMAD3 SMAD3 SOX11 SOX11 FBN2 FBN2 ENSPTRP00000092364 ENSPTRP00000092364 OSR2 OSR2 PTPN11 PTPN11 DHRS3 DHRS3 MATN1 MATN1 CCN1 CCN1 ECM1 ECM1 BGLAP BGLAP DDR2 DDR2 TGFB2 TGFB2 DKK1 DKK1 EGR2 EGR2 SRGN SRGN BMPR1A BMPR1A PTH PTH NELL1 NELL1 ESRRA ESRRA LTBP3 LTBP3 ZBTB16 ZBTB16 FGF23 FGF23 WNT10B WNT10B CYP27B1 CYP27B1 KL KL BMP4 BMP4 HIF1A HIF1A TGFB3 TGFB3 SMAD6 SMAD6 KREMEN2 KREMEN2 RFLNB RFLNB SOST SOST PHOSPHO1 PHOSPHO1 SOX9 SOX9 SMAD7 SMAD7 TGFB1 TGFB1 TRPM4 TRPM4 OSR1 OSR1 ATRAID ATRAID PKDCC PKDCC SIX2 SIX2 TACR1 TACR1 ACVR2A ACVR2A OXT OXT GFRA4 GFRA4 BMP2 BMP2 BMP7 BMP7 MAPK1 MAPK1 LTF LTF AHSG AHSG STATH STATH BMPR1B BMPR1B INTU INTU PTGER4 PTGER4 ADGRV1 ADGRV1 ADRB2 ADRB2 BMP6 BMP6 RXRB RXRB MAPK14 MAPK14 PTK2B PTK2B OMD OMD NOTCH1 NOTCH1 TXLNG TXLNG BCOR BCOR GDF10 GDF10 ATP2B1 ATP2B1 RXRA RXRA CK820_G0054574 CK820_G0054574 FZD9 FZD9 TWIST1 TWIST1 NIPBL NIPBL IFITM5 IFITM5 BMPR2 BMPR2 ENPP1 ENPP1 KREMEN1 KREMEN1 RFLNA RFLNA P2RX7 P2RX7 NOTUM NOTUM SFRP1 SFRP1 BMP2K BMP2K MAPK3 MAPK3 TXLNGY TXLNGY CK820_G0015936 CK820_G0015936 PHOSPHO2 PHOSPHO2 COMP COMP ENSPTRP00000060558 ENSPTRP00000060558 ISG15 ISG15 S1PR1 S1PR1 PBX1 PBX1 CK820_G0042363 CK820_G0042363 ENSPTRP00000062265 ENSPTRP00000062265 WNT4 WNT4 CALCA CALCA SLC8A1 SLC8A1 ENSPTRP00000064416 ENSPTRP00000064416 ANO6 ANO6 TENT5A TENT5A SGMS2 SGMS2 RUNX2 RUNX2 ALOX5 ALOX5 ENSPTRP00000067174 ENSPTRP00000067174 NBR1 NBR1 CSF1 CSF1 TMEM119 TMEM119 PTPN11-2 PTPN11-2 CALCR CALCR GPM6B GPM6B ENSPTRP00000074763 ENSPTRP00000074763 ENSPTRP00000075468 ENSPTRP00000075468 ACVR1 ACVR1 ENSPTRP00000077036 ENSPTRP00000077036 ACVR2B ACVR2B ENSPTRP00000077211 ENSPTRP00000077211 CCR1 CCR1 BCOR-2 BCOR-2 TPH1 TPH1 LOC745935 LOC745935 LOC100612565 LOC100612565 RBPJ RBPJ ZMPSTE24 ZMPSTE24 PTN PTN BMP4-2 BMP4-2 LRP4 LRP4 SCUBE2 SCUBE2 VDR VDR MDK MDK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACTN3Actinin alpha 3 (gene/pseudogene). (944 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ANKHANKH inorganic pyrophosphate transport regulator. (492 aa)
GATA1GATA binding protein 1. (413 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. (128 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
SOX11Transcription factor SOX. (441 aa)
FBN2FBN2 isoform 1. (2912 aa)
ENSPTRP00000092364annotation not available (574 aa)
OSR2Protein odd-skipped-related 2 isoform X4. (433 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
DHRS3Dehydrogenase/reductase (SDR family) member 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
MATN1MATN1 isoform 1. (496 aa)
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
ECM1Extracellular matrix protein 1. (540 aa)
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (100 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
DKK1Dickkopf-like protein 1. (289 aa)
EGR2Early growth response 2. (476 aa)
SRGNSRGN isoform 1. (162 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
NELL1Neural EGFL like 1. (838 aa)
ESRRAEstrogen-related receptor alpha. (422 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1297 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
KLKL isoform 1. (1012 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
KREMEN2Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (462 aa)
RFLNBRFLNB isoform 1. (144 aa)
SOSTSOST isoform 1. (213 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase. (267 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TRPM4Transient receptor potential cation channel, subfamily M, member 4. (1306 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
ATRAIDAll-trans retinoic acid induced differentiation factor. (284 aa)
PKDCCPKDCC isoform 1. (461 aa)
SIX2SIX homeobox 2. (291 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
GFRA4GFRA4 isoform 1. (269 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
LTFLactotransferrin; Belongs to the transferrin family. (711 aa)
AHSGAlpha-2-HS-glycoprotein chain A; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions (By similarity); Belongs to the fetuin family. (368 aa)
STATHSTATH isoform 1. (62 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
INTUInturned planar cell polarity effector homolog. (911 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function (By similarity). Belongs to the G-protein coupled receptor 1 family. (490 aa)
ADGRV1ADGRV1 isoform 1; Belongs to the G-protein coupled receptor 2 family. (6306 aa)
ADRB2Adrenergic, beta-2-, receptor, surface. (429 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
RXRBRetinoid X receptor, beta. (537 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
PTK2BPTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
OMDOMD isoform 1. (421 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
TXLNGTXLNG isoform 1. (561 aa)
BCORBCL6 corepressor. (1755 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
RXRARetinoid X receptor, alpha. (462 aa)
CK820_G0054574ISG15 isoform 1. (159 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
TWIST1TWIST1 isoform 2. (163 aa)
NIPBLNipped-B protein. (2804 aa)
IFITM5Interferon induced transmembrane protein 5. (132 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
ENPP1ENPP1 isoform 1. (925 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)
RFLNARFLNA isoform 1. (216 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (496 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
BMP2KBMP2 inducible kinase. (1162 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
TXLNGYPutative gamma-taxilin 2; Belongs to the taxilin family. (143 aa)
CK820_G0015936C12orf76 isoform 1. (107 aa)
PHOSPHO2Phosphatase, orphan 2. (241 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
ENSPTRP00000060558annotation not available (149 aa)
ISG15ISG15 ubiquitin-like modifier. (165 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
PBX1Pre-B-cell leukemia homeobox 1. (486 aa)
CK820_G0042363TRPM4 isoform 1. (1251 aa)
ENSPTRP00000062265annotation not available (82 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
ENSPTRP00000064416annotation not available (502 aa)
ANO6Anoctamin. (931 aa)
TENT5ATerminal nucleotidyltransferase 5A. (452 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
ALOX5ALOX5 isoform 2. (785 aa)
ENSPTRP00000067174annotation not available (502 aa)
NBR1NBR1 isoform 1. (985 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (585 aa)
TMEM119Transmembrane protein 119. (283 aa)
PTPN11-2Protein tyrosine phosphatase non-receptor type 11. (579 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (509 aa)
GPM6BGlycoprotein M6B. (305 aa)
ENSPTRP00000074763annotation not available (520 aa)
ENSPTRP00000075468annotation not available (220 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
ENSPTRP00000077036annotation not available (396 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
ENSPTRP00000077211annotation not available (269 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
BCOR-2BCL6 corepressor. (1755 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
LOC745935C-C motif chemokine. (87 aa)
LOC100612565Steroid hormone receptor ERR1 pseudogene. (396 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
PTNPTN isoform 2. (172 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
LRP4Low density lipoprotein receptor-related protein 4. (1906 aa)
SCUBE2SCUBE2 isoform 2. (996 aa)
VDRVitamin D (1,25-dihydroxyvitamin D3) receptor. (477 aa)
MDKMidkine (Neurite growth-promoting factor 2). (143 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.