39 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VDR	Vitamin D (1,25-dihydroxyvitamin D3) receptor. (477 aa)
	ECM1	Extracellular matrix protein 1. (540 aa)
	DKK1	Dickkopf-like protein 1. (289 aa)
	SRGN	SRGN isoform 1. (162 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
	LTBP3	Latent transforming growth factor beta binding protein 3. (1297 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (850 aa)
	SMAD6	Mothers against decapentaplegic homolog. (496 aa)
	KREMEN2	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (462 aa)
	RFLNB	RFLNB isoform 1. (144 aa)
	SOST	SOST isoform 1. (213 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	SMAD7	Mothers against decapentaplegic homolog. (491 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	TRPM4	Transient receptor potential cation channel, subfamily M, member 4. (1306 aa)
	GFRA4	GFRA4 isoform 1. (269 aa)
	AHSG	Alpha-2-HS-glycoprotein chain A; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions (By similarity); Belongs to the fetuin family. (368 aa)
	STATH	STATH isoform 1. (62 aa)
	PTK2B	PTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	NOTCH1	NOTCH1 isoform 1. (2555 aa)
	BCOR	BCL6 corepressor. (1755 aa)
	ENPP1	ENPP1 isoform 1. (925 aa)
	KREMEN1	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)
	RFLNA	RFLNA isoform 1. (216 aa)
	SFRP1	Secreted frizzled-related protein 1. (314 aa)
	CK820_G0042363	TRPM4 isoform 1. (1251 aa)
	CALCA	Calcitonin related polypeptide alpha. (141 aa)
	CALCR	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (509 aa)
	CCR1	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
	BCOR-2	BCL6 corepressor. (1755 aa)
	TPH1	Tryptophan hydroxylase 1. (444 aa)
	LOC745935	C-C motif chemokine. (87 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (500 aa)
	LRP4	Low density lipoprotein receptor-related protein 4. (1906 aa)
	MDK	Midkine (Neurite growth-promoting factor 2). (143 aa)
	GATA1	GATA binding protein 1. (413 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHSG	ENPP1	ENSPTRP00000027036	ENSPTRP00000049619	Alpha-2-HS-glycoprotein chain A; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions (By similarity); Belongs to the fetuin family.	ENPP1 isoform 1.	0.494
AHSG	FGF23	ENSPTRP00000027036	ENSPTRP00000007781	Alpha-2-HS-glycoprotein chain A; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions (By similarity); Belongs to the fetuin family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.551
AHSG	PTH	ENSPTRP00000027036	ENSPTRP00000005898	Alpha-2-HS-glycoprotein chain A; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions (By similarity); Belongs to the fetuin family.	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family.	0.489
AHSG	SOST	ENSPTRP00000027036	ENSPTRP00000015741	Alpha-2-HS-glycoprotein chain A; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions (By similarity); Belongs to the fetuin family.	SOST isoform 1.	0.474
BCL2	HIF1A	ENSPTRP00000090293	ENSPTRP00000010887	BCL2 apoptosis regulator.	Hypoxia inducible factor 1 subunit alpha.	0.803
BCL2	NOTCH1	ENSPTRP00000090293	ENSPTRP00000036924	BCL2 apoptosis regulator.	NOTCH1 isoform 1.	0.569
BCL2	TGFB1	ENSPTRP00000090293	ENSPTRP00000018930	BCL2 apoptosis regulator.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.509
CALCA	CALCR	ENSPTRP00000063998	ENSPTRP00000073275	Calcitonin related polypeptide alpha.	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	0.999
CALCA	PTH	ENSPTRP00000063998	ENSPTRP00000005898	Calcitonin related polypeptide alpha.	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family.	0.658
CALCR	CALCA	ENSPTRP00000073275	ENSPTRP00000063998	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	Calcitonin related polypeptide alpha.	0.999
CALCR	PTH	ENSPTRP00000073275	ENSPTRP00000005898	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family.	0.740
CCR1	LOC745935	ENSPTRP00000077385	ENSPTRP00000079006	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.570
DKK1	FGF23	ENSPTRP00000004327	ENSPTRP00000007781	Dickkopf-like protein 1.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.460
DKK1	KREMEN1	ENSPTRP00000004327	ENSPTRP00000049742	Dickkopf-like protein 1.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.988
DKK1	KREMEN2	ENSPTRP00000004327	ENSPTRP00000013102	Dickkopf-like protein 1.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.961
DKK1	LRP4	ENSPTRP00000004327	ENSPTRP00000082021	Dickkopf-like protein 1.	Low density lipoprotein receptor-related protein 4.	0.732
DKK1	PTH	ENSPTRP00000004327	ENSPTRP00000005898	Dickkopf-like protein 1.	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family.	0.485
DKK1	SFRP1	ENSPTRP00000004327	ENSPTRP00000053182	Dickkopf-like protein 1.	Secreted frizzled-related protein 1.	0.780
DKK1	SOST	ENSPTRP00000004327	ENSPTRP00000015741	Dickkopf-like protein 1.	SOST isoform 1.	0.789
ENPP1	AHSG	ENSPTRP00000049619	ENSPTRP00000027036	ENPP1 isoform 1.	Alpha-2-HS-glycoprotein chain A; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions (By similarity); Belongs to the fetuin family.	0.494