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ANK3 ANK3 ATP1B1 ATP1B1 CASQ1 CASQ1 CK820_G0029100 CK820_G0029100 ATP1A1 ATP1A1 SCN1B SCN1B CACNB3 CACNB3 ENSPTRP00000086247 ENSPTRP00000086247 ENSPTRP00000085680 ENSPTRP00000085680 ADRA1A ADRA1A VDR VDR ATP1A2 ATP1A2 ASB3 ASB3 SRI-2 SRI-2 SRI SRI SLC30A1 SLC30A1 ENSPTRP00000078278 ENSPTRP00000078278 CACNG4 CACNG4 CACNA1D CACNA1D CACNA1S CACNA1S SCN2A SCN2A FER1L5 FER1L5 RDX RDX CACNA2D1 CACNA2D1 SCN5A SCN5A ATP2B4 ATP2B4 SLC9A1 SLC9A1 PPP3CB PPP3CB SLC8A1 SLC8A1 RTN2 RTN2 LOC453361 LOC453361 DYSF DYSF AHNAK2 AHNAK2 CACNG8 CACNG8 KCNJ11 KCNJ11 ANK2 ANK2 CACNB2 CACNB2 NOS1AP NOS1AP STBD1 STBD1 AHNAK AHNAK STAC STAC CAV3 CAV3 SCN1A SCN1A KCNJ3 KCNJ3 BIN1 BIN1 CACNG6 CACNG6 CACNG7 CACNG7 FXYD1 FXYD1 AQP4 AQP4 KCNJ2 KCNJ2 CACNG1 CACNG1 SLC2A4 SLC2A4 IGF1R IGF1R TGFB3 TGFB3 AKAP6 AKAP6 STAC3 STAC3 CACNA1C CACNA1C
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ANK3ANK3 isoform 5. (4377 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). (303 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (396 aa)
CK820_G0029100SRI isoform 2. (98 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
SCN1BSodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. (268 aa)
CACNB3Calcium channel, voltage-dependent, beta 3 subunit. (487 aa)
ENSPTRP00000086247annotation not available (513 aa)
ENSPTRP00000085680annotation not available (88 aa)
ADRA1AAdrenoceptor alpha 1A. (495 aa)
VDRVitamin D (1,25-dihydroxyvitamin D3) receptor. (477 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
ASB3Ankyrin repeat and SOCS box containing 3. (556 aa)
SRI-2SRI isoform 5. (237 aa)
SRISRI isoform 1. (205 aa)
SLC30A1Solute carrier family 30 (Zinc transporter), member 1. (507 aa)
ENSPTRP00000078278annotation not available (260 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2005 aa)
FER1L5FER1L5 isoform 5. (1974 aa)
RDXRDX isoform 3. (609 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
PPP3CBSerine/threonine-protein phosphatase. (526 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
RTN2Reticulon. (545 aa)
LOC453361CAPN3 isoform 4; Belongs to the peptidase C2 family. (821 aa)
DYSFDYSF isoform 8. (2119 aa)
AHNAK2AHNAK2 isoform 3. (5128 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (427 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
ANK2ANK2 isoform 1. (3957 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
NOS1APNitric oxide synthase 1 adaptor protein. (506 aa)
STBD1Starch-binding domain-containing protein 1. (358 aa)
AHNAKAHNAK isoform 5. (5891 aa)
STACSH3 and cysteine rich domain. (402 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2009 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
BIN1Bridging integrator 1. (597 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (260 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (81 aa)
AQP4AQP4 isoform 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
KCNJ2Potassium inwardly-rectifying channel, subfamily J, member 2. (427 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (222 aa)
SLC2A4SLC2A4 isoform 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (466 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
AKAP6A-kinase anchoring protein 6. (2319 aa)
STAC3SH3 and cysteine rich domain 3. (364 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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