STRINGSTRING
SRC SRC EPHA2 EPHA2 IL20 IL20 TRAF6 TRAF6 TCIRG1 TCIRG1 IAPP IAPP TNFSF11 TNFSF11 GPR183 GPR183 IREB2 IREB2 NF1 NF1 SBNO2 SBNO2 TGFB1 TGFB1 OCSTAMP OCSTAMP TF TF MAPK14 MAPK14 GLO1 GLO1 TREM2 TREM2 OSTM1 OSTM1 SNX10 SNX10 DCSTAMP DCSTAMP CCN4 CCN4 CK820_G0008402 CK820_G0008402 ATP6AP1 ATP6AP1 CTNNB1 CTNNB1 GAB2 GAB2 TFRC TFRC JUNB JUNB EFNA2 EFNA2 SFRP1 SFRP1 ENSPTRP00000065244 ENSPTRP00000065244 ENSPTRP00000066121 ENSPTRP00000066121 CK820_G0008402-2 CK820_G0008402-2 OSCAR OSCAR TNF TNF CSF1 CSF1 CREB1 CREB1 CALCR CALCR CD81 CD81 CD109 CD109 FOXP1 FOXP1 PIK3R1 PIK3R1 PAFAH1B1 PAFAH1B1 FOS FOS SH3PXD2A SH3PXD2A CSF1R CSF1R FARP2 FARP2 CK820_G0041942 CK820_G0041942 ANXA2 ANXA2 MITF MITF GPR68 GPR68 TNFRSF11A TNFRSF11A LRRK1 LRRK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRCTyrosine-protein kinase. (542 aa)
EPHA2EPH receptor A2. (976 aa)
IL20IL20 isoform 1. (176 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
IAPPIslet amyloid polypeptide. (89 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (361 aa)
IREB2Iron-responsive element-binding protein 2; Belongs to the aconitase/IPM isomerase family. (963 aa)
NF1Neurofibromin 1. (2839 aa)
SBNO2SBNO2 isoform 2. (1350 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
OCSTAMPOCSTAMP isoform 1. (565 aa)
TFSerotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation (By similarity). (698 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
GLO1Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (184 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
OSTM1Osteoclastogenesis associated transmembrane protein 1. (334 aa)
SNX10Sorting nexin 10. (201 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
CCN4WISP1 isoform 1. (367 aa)
CK820_G0008402Annexin. (233 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (470 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
GAB2GRB2-associated-binding protein 2. (676 aa)
TFRCTransferrin receptor (P90, CD71). (760 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
EFNA2EFNA2 isoform 1; Belongs to the ephrin family. (190 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
ENSPTRP00000065244annotation not available (463 aa)
ENSPTRP00000066121annotation not available (305 aa)
CK820_G0008402-2Annexin. (325 aa)
OSCAROSCAR isoform 3. (305 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (585 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (509 aa)
CD81CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...] (303 aa)
CD109CD109 isoform 3. (1446 aa)
FOXP1FOXP1 isoform 2. (693 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (413 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SH3PXD2ASH3 and PX domains 2A. (1133 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
FARP2FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1054 aa)
CK820_G0041942OSCAR isoform 2. (252 aa)
ANXA2Annexin. (357 aa)
MITFMITF isoform 1. (519 aa)
GPR68GPR68 isoform 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
TNFRSF11ATNF receptor superfamily member 11a. (617 aa)
LRRK1Leucine-rich repeat kinase 1. (2015 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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