STRINGSTRING
LTBP3 LTBP3 FGFR2 FGFR2 LIPA LIPA BMPR1A BMPR1A DLG5 DLG5 NODAL NODAL HSD11B1 HSD11B1 CHI3L1 CHI3L1 HMGCS2 HMGCS2 EDN2 EDN2 STK40 STK40 PDPN PDPN ERRFI1 ERRFI1 BMP4 BMP4 NUMA1 NUMA1 ENSPTRP00000093474 ENSPTRP00000093474 PTGES3 PTGES3 TAB1 TAB1 ENSPTRP00000092218 ENSPTRP00000092218 NKIRAS2 NKIRAS2 FGF18 FGF18 MMP12 MMP12 SOX11 SOX11 SIM2 SIM2 MME MME CCN2 CCN2 LAMA5 LAMA5 TMEM38B TMEM38B PTK7 PTK7 SELENON SELENON WNT5A WNT5A LAMA1 LAMA1 SP3 SP3 ENSPTRP00000085332 ENSPTRP00000085332 DPPA4 DPPA4 FNDC3B FNDC3B KRAS KRAS CK820_G0054628 CK820_G0054628 FGF10 FGF10 RBBP9 RBBP9 SPRY1 SPRY1 LOC104001457 LOC104001457 BMP4-2 BMP4-2 THRB THRB ENSPTRP00000080279 ENSPTRP00000080279 PDGFRB PDGFRB RBPJ RBPJ STRA6 STRA6 GLI1 GLI1 SFTPD SFTPD RAB3A RAB3A ASCL1 ASCL1 LOC100611246 LOC100611246 ACVR2B ACVR2B SREBF1 SREBF1 SHH SHH FGF8 FGF8 ENSPTRP00000075643 ENSPTRP00000075643 TGFBR2 TGFBR2 ZFPM2 ZFPM2 HSPB11 HSPB11 ITGB6 ITGB6 YWHAZ YWHAZ LOXL3 LOXL3 ADA ADA CREB1 CREB1 NKX2-1 NKX2-1 ASXL1 ASXL1 CYP1A2 CYP1A2 EIF4E EIF4E TBX5 TBX5 SLC7A11 SLC7A11 ENSPTRP00000068117 ENSPTRP00000068117 FGF2 FGF2 ENSPTRP00000067051 ENSPTRP00000067051 ENSPTRP00000066621 ENSPTRP00000066621 CLCN2 CLCN2 ZIC3 ZIC3 BAG6 BAG6 PHF14 PHF14 HOPX HOPX CK820_G0056924 CK820_G0056924 ENSPTRP00000064416 ENSPTRP00000064416 ENSPTRP00000064242 ENSPTRP00000064242 ATP7A ATP7A HES1 HES1 RSPO2 RSPO2 FBXW9 FBXW9 WNT7B WNT7B LHX3 LHX3 FOXA1 FOXA1 SMAD2 SMAD2 ATXN1L ATXN1L CELSR1 CELSR1 NFIB NFIB MAPK3 MAPK3 AARD AARD TTC25 TTC25 PROX1 PROX1 CCDC39 CCDC39 BMPR2 BMPR2 MAN2A1 MAN2A1 RXFP1 RXFP1 SLC23A1 SLC23A1 HIKESHI HIKESHI DNAAF1 DNAAF1 FLT4 FLT4 CTNNB1 CTNNB1 CRISPLD2 CRISPLD2 MAN1A2 MAN1A2 TIMELESS TIMELESS ADAMTSL2 ADAMTSL2 GLI2 GLI2 ELK1 ELK1 PHEX PHEX NOTCH1 NOTCH1 RC3H2 RC3H2 EXT1 EXT1 GRHL2 GRHL2 RIDA RIDA RDH10 RDH10 CRH CRH NOS3 NOS3 WNT2 WNT2 PLOD3 PLOD3 GLI3 GLI3 HOXA5 HOXA5 AGR2 AGR2 AIMP2 AIMP2 TCF21 TCF21 ARG1 ARG1 SRF SRF SPDEF SPDEF ADAMTS2 ADAMTS2 FGF1 FGF1 LOX LOX AP3B1 AP3B1 FBXW7 FBXW7 HHIP HHIP SEC24B SEC24B KDR KDR EIF4G1 EIF4G1 HEG1 HEG1 DAG1 DAG1 NKIRAS1 NKIRAS1 EP300 EP300 LIF LIF MAPK1 MAPK1 CTSZ CTSZ IGFBP5 IGFBP5 ABCA12 ABCA12 COL3A1 COL3A1 HS6ST1 HS6ST1 EPAS1 EPAS1 PKDCC PKDCC RCN3 RCN3 TGFB1 TGFB1 KLF2 KLF2 MAP2K2 MAP2K2 CCBE1 CCBE1 GATA6 GATA6 CCDC40 CCDC40 JMJD6 JMJD6 FOXJ1 FOXJ1 SOX9 SOX9 TBX4 TBX4 TBX2 TBX2 NOG NOG ITGA3 ITGA3 THRA THRA MYOCD MYOCD FOXF1 FOXF1 SMPD3 SMPD3 ESRP2 ESRP2 ABCA3 ABCA3 CTSH CTSH ALDH1A2 ALDH1A2 FGF7 FGF7 TGFB3 TGFB3 SAV1 SAV1 NKX2-8 NKX2-8 MMP14 MMP14 SPRY2 SPRY2 FGF9 FGF9 PPP1CA PPP1CA LTA4H LTA4H YAP1 YAP1 PGR PGR WNT11 WNT11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LTBP3Latent transforming growth factor beta binding protein 3. (1297 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1919 aa)
NODALNODAL isoform 2. (347 aa)
HSD11B1Hydroxysteroid (11-beta) dehydrogenase 1. (292 aa)
CHI3L1Chitinase 3-like 1 (Cartilage glycoprotein-39); Belongs to the glycosyl hydrolase 18 family. (383 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
EDN2EDN2 isoform 1. (178 aa)
STK40Serine/threonine kinase 40. (440 aa)
PDPNPDPN isoform 3. (238 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2111 aa)
ENSPTRP00000093474Cadherin EGF LAG seven-pass G-type receptor 1. (124 aa)
PTGES3Prostaglandin E synthase 3. (164 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa)
ENSPTRP00000092218annotation not available (738 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (229 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MMP12MMP12 isoform 1. (470 aa)
SOX11Transcription factor SOX. (441 aa)
SIM2SIM bHLH transcription factor 2. (667 aa)
MMEMembrane metallo-endopeptidase. (750 aa)
CCN2CTGF isoform 1. (349 aa)
LAMA5Laminin, alpha 5. (2203 aa)
TMEM38BTransmembrane protein 38B. (297 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
SELENONT0161445 isoform 2. (581 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
LAMA1Laminin subunit alpha 1. (3104 aa)
SP3Sp3 transcription factor. (781 aa)
ENSPTRP00000085332annotation not available (174 aa)
DPPA4DPPA4 isoform 1. (268 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
CK820_G0054628PKD1 isoform 4. (3384 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
RBBP9RB binding protein 9, serine hydrolase. (186 aa)
SPRY1Sprouty homolog 1, antagonist of FGF signaling. (319 aa)
LOC104001457Prostaglandin E synthase 3-like isoform X1. (160 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
THRBThyroid hormone receptor beta. (476 aa)
ENSPTRP00000080279annotation not available (270 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
STRA6Stimulated by retinoic acid 6. (706 aa)
GLI1GLI family zinc finger 1. (1106 aa)
SFTPDSurfactant protein D. (375 aa)
RAB3ARAB3A, member RAS oncogene family. (220 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
LOC10061124614-3-3 protein zeta/delta pseudogene. (212 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
SREBF1SREBF1 isoform 6. (1177 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
ENSPTRP00000075643Prostaglandin E synthase 3-like isoform X1. (165 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
ZFPM2ZFPM2 isoform 3. (1151 aa)
HSPB11Heat shock protein family B (small) member 11. (214 aa)
ITGB6ITGB6 isoform 3. (701 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; Belongs to the 14-3-3 family. (245 aa)
LOXL3Lysyl oxidase-like 3. (753 aa)
ADAAdenosine deaminase. (412 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
NKX2-1NKX2-1 isoform 1. (401 aa)
ASXL1ASXL transcriptional regulator 1. (1548 aa)
CYP1A2Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (517 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
TBX5T-box transcription factor 5. (518 aa)
SLC7A11Solute carrier family 7, (Cationic amino acid transporter, y+ system) member 11. (515 aa)
ENSPTRP00000068117annotation not available (318 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
ENSPTRP00000067051annotation not available (137 aa)
ENSPTRP00000066621annotation not available (709 aa)
CLCN2Chloride channel protein. (898 aa)
ZIC3Zic family member 3. (466 aa)
BAG6BAG6 isoform 3. (1162 aa)
PHF14PHD finger protein 14. (948 aa)
HOPXHOPX isoform 3. (112 aa)
CK820_G0056924NPIPA2 isoform 1. (277 aa)
ENSPTRP00000064416annotation not available (502 aa)
ENSPTRP00000064242annotation not available (213 aa)
ATP7AATPase, Cu++ transporting, alpha polypeptide. (1500 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
RSPO2R-spondin 2 homolog. (243 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
LHX3LHX3 isoform 2. (402 aa)
FOXA1FOXA1 isoform 1. (471 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ATXN1LATXN1L isoform 2. (689 aa)
CELSR1CELSR1 isoform 1; Belongs to the G-protein coupled receptor 2 family. (2998 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
AARDAlanine and arginine rich domain containing protein. (154 aa)
TTC25TTC25 isoform 1. (662 aa)
PROX1Prospero homeobox 1. (737 aa)
CCDC39Coiled-coil domain containing 39. (941 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
MAN2A1Alpha-mannosidase. (1144 aa)
RXFP1RXFP1 isoform 5. (779 aa)
SLC23A1Solute carrier family 23 member 1. (602 aa)
HIKESHIHeat shock protein nuclear import factor hikeshi. (197 aa)
DNAAF1Dynein assembly factor 1, axonemal. (725 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
CRISPLD2Cysteine-rich secretory protein LCCL domain containing 2. (497 aa)
MAN1A2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (641 aa)
TIMELESSTimeless circadian regulator. (1209 aa)
ADAMTSL2ADAMTSL2 isoform 2. (1059 aa)
GLI2GLI family zinc finger 2. (1587 aa)
ELK1ELK1, member of ETS oncogene family. (428 aa)
PHEXPhosphate regulating endopeptidase homolog X-linked. (749 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
RIDAReactive intermediate imine deaminase A homolog. (137 aa)
RDH10Retinol dehydrogenase 10 (All-trans); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
CRHCorticotropin releasing hormone. (196 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
PLOD3Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3. (738 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
HOXA5HOXA5 isoform 1. (270 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
AIMP2AIMP2 isoform 6. (320 aa)
TCF21Transcription factor 21. (179 aa)
ARG1Arginase. (322 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif, 2. (1076 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
LOXLOX isoform 1. (417 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1045 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
HHIPHedgehog interacting protein. (700 aa)
SEC24BSEC24B isoform 1. (1286 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1559 aa)
HEG1HEG1 isoform 1. (1381 aa)
DAG1Dystroglycan 1 (Dystrophin-associated glycoprotein 1). (895 aa)
NKIRAS1NF-kappa-B inhibitor-interacting Ras-like protein 1. (192 aa)
EP300E1A binding protein p300. (2175 aa)
LIFLeukemia inhibitory factor (Cholinergic differentiation factor). (202 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CTSZCTSZ isoform 1; Belongs to the peptidase C1 family. (303 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (272 aa)
ABCA12ATP binding cassette subfamily A member 12. (2595 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
HS6ST1Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (411 aa)
EPAS1Endothelial PAS domain protein 1. (870 aa)
PKDCCPKDCC isoform 1. (461 aa)
RCN3Reticulocalbin 3, EF-hand calcium binding domain. (336 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
KLF2Kruppel-like factor 2 (Lung). (355 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
GATA6GATA binding protein 6. (594 aa)
CCDC40CCDC40 isoform 3. (1142 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (420 aa)
FOXJ1FOXJ1 isoform 1. (421 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
TBX4TBX4 isoform 1. (545 aa)
TBX2T-box transcription factor 2. (712 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ITGA3ITGA3 isoform 6; Belongs to the integrin alpha chain family. (1066 aa)
THRAThyroid hormone receptor, alpha (Erythroblastic leukemia viral (V-erb-a) oncogene homolog, avian). (617 aa)
MYOCDMYOCD isoform 2. (986 aa)
FOXF1FOXF1 isoform 1. (433 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
ESRP2Epithelial splicing regulatory protein 2. (717 aa)
ABCA3ABCA3 isoform 2. (1698 aa)
CTSHCTSH isoform 11; Belongs to the peptidase C1 family. (335 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
NKX2-8NKX2-8 isoform 1. (239 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
SPRY2Sprouty homolog 2. (338 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (455 aa)
LTA4HLeukotriene A(4) hydrolase; Belongs to the peptidase M1 family. (611 aa)
YAP1Yes-associated protein 1. (508 aa)
PGRProgesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. (933 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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