STRINGSTRING
MSX1 MSX1 SMAD9 SMAD9 CK820_G0012168 CK820_G0012168 TMPRSS6 TMPRSS6 SMAD2 SMAD2 RGMA RGMA ATF2 ATF2 HES1 HES1 ENSPTRP00000064416 ENSPTRP00000064416 RUNX2 RUNX2 TGFBR3 TGFBR3 SOSTDC1 SOSTDC1 USP9X USP9X ETV2 ETV2 GDF2 GDF2 ABL1 ABL1 SCX SCX USP15 USP15 ACVR1 ACVR1 NOTCH2 NOTCH2 GDF6 GDF6 HIVEP1 HIVEP1 PPARG PPARG ACVR2B ACVR2B BMP10 BMP10 ENSPTRP00000079019 ENSPTRP00000079019 HFE HFE LEFTY1 LEFTY1 LEF1 LEF1 ZCCHC18 ZCCHC18 SMAD5 SMAD5 PDCD4 PDCD4 HES5-2 HES5-2 BMP4-2 BMP4-2 RGMB RGMB CHRDL1 CHRDL1 EGR1 EGR1 GDF9-2 GDF9-2 HJV HJV CHRD CHRD WNT5A WNT5A TMEM100 TMEM100 SOSTDC1-2 SOSTDC1-2 SMAD3 SMAD3 DLX3 DLX3 SOST SOST FAM83G FAM83G SMPD3 SMPD3 SMAD6 SMAD6 TGFB3 TGFB3 BMP4 BMP4 SLC39A5 SLC39A5 ACVRL1 ACVRL1 GDF3 GDF3 BMPR1A BMPR1A NODAL NODAL LEFTY2 LEFTY2 TGFB2 TGFB2 BMP8B BMP8B ENSPTRP00000000998 ENSPTRP00000000998 NOG NOG DDX5 DDX5 TWSG1 TWSG1 SMAD7 SMAD7 SMAD4 SMAD4 GDF15 GDF15 FKBP8 FKBP8 TGFB1 TGFB1 MEGF8 MEGF8 ZNF8 ZNF8 GDF7 GDF7 CCDC142 CCDC142 ACVR2A ACVR2A BMP2 BMP2 GDF5 GDF5 BMP7 BMP7 ZNF831 ZNF831 BMPR1B BMPR1B SMAD1 SMAD1 SFRP2 SFRP2 FST FST GDF9 GDF9 BMP6 BMP6 BMP5 BMP5 BMPER BMPER DLX5 DLX5 EXT1 EXT1 ENG ENG BMP15 BMP15 ZCCHC12 ZCCHC12 USP9Y USP9Y HES5 HES5 SPART SPART DSG4 DSG4 SLC33A1 SLC33A1 SMURF1 SMURF1 BMPR2 BMPR2 SFRP1 SFRP1 MAPK3 MAPK3 COMP COMP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
TMPRSS6TMPRSS6 isoform 2; Belongs to the peptidase S1 family. (824 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
ENSPTRP00000064416annotation not available (502 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
USP9XUbiquitin specific peptidase 9, X-linked; Belongs to the peptidase C19 family. (2591 aa)
ETV2ETV2 isoform 5. (370 aa)
GDF2GDF2 isoform 1. (429 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
GDF6Growth differentiation factor 6. (455 aa)
HIVEP1HIVEP1 isoform 1. (2718 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
ENSPTRP00000079019annotation not available (165 aa)
HFEHereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. (348 aa)
LEFTY1Left-right determination factor. (366 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
ZCCHC18ZCCHC18 isoform 2. (377 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
PDCD4Programmed cell death 4 (Neoplastic transformation inhibitor). (469 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (478 aa)
CHRDL1CHRDL1 isoform 3. (458 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
GDF9-2Growth differentiation factor 9. (455 aa)
HJVHFE2 isoform 1. (426 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (955 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TMEM100Transmembrane protein 100. (134 aa)
SOSTDC1-2Sclerostin domain containing 1. (206 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
DLX3Distal-less homeobox 3. (287 aa)
SOSTSOST isoform 1. (213 aa)
FAM83GFamily with sequence similarity 83, member G. (823 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SLC39A5Solute carrier family 39 member 5. (540 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
GDF3Growth differentiation factor 3. (364 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NODALNODAL isoform 2. (347 aa)
LEFTY2Left-right determination factor. (366 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BMP8BBMP8B isoform 1. (402 aa)
ENSPTRP00000000998annotation not available (224 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GDF15Growth differentiation factor 15. (308 aa)
FKBP8Peptidylprolyl isomerase. (413 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MEGF8Multiple EGF like domains 8. (2842 aa)
ZNF8KRAB domain-containing zinc finger protein. (575 aa)
GDF7Growth differentiation factor 7. (447 aa)
CCDC142Coiled-coil domain containing 142. (750 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
GDF5GDF5 isoform 1. (501 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
ZNF831Zinc finger protein 831. (1679 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SMAD1Mothers against decapentaplegic homolog. (469 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
FSTFST isoform 1. (344 aa)
GDF9Growth differentiation factor 9. (455 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
BMPERBMP binding endothelial regulator. (685 aa)
DLX5Distal-less homeobox 5. (289 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
ENGENG isoform 1. (658 aa)
BMP15BMP15 isoform 1. (369 aa)
ZCCHC12Zinc finger CCHC-type containing 12. (402 aa)
USP9YUSP9Y isoform 1; Belongs to the peptidase C19 family. (2523 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
SPARTSpastic paraplegia 20 (Troyer syndrome). (665 aa)
DSG4DSG4 isoform 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1059 aa)
SLC33A1Solute carrier family 33 (Acetyl-CoA transporter), member 1. (549 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.