STRINGSTRING
PPARG PPARG GATA4 GATA4 NOTCH2 NOTCH2 CTDSPL2 CTDSPL2 UBE2D3 UBE2D3 SULF1 SULF1 ABL1 ABL1 SKIL SKIL SKOR2 SKOR2 CHRDL2 CHRDL2 NBL1 NBL1 GDF2 GDF2 FBN1 FBN1 SOSTDC1 SOSTDC1 SFRP5 SFRP5 ILK ILK FBXL15 FBXL15 HES1 HES1 HOXA13 HOXA13 ENSPTRP00000063212 ENSPTRP00000063212 RGMA RGMA SMAD2 SMAD2 TMPRSS6 TMPRSS6 CK820_G0012168 CK820_G0012168 ENSPTRP00000061118 ENSPTRP00000061118 KIAA1324L KIAA1324L SCUBE3 SCUBE3 MSX1 MSX1 SFRP1 SFRP1 TNFAIP6 TNFAIP6 BMPR2 BMPR2 HOXA13-2 HOXA13-2 SMURF1 SMURF1 PCSK6 PCSK6 CRB2 CRB2 SPART SPART HES5 HES5 DLX1 DLX1 NOTCH1 NOTCH1 ENG ENG CER1 CER1 HIPK2 HIPK2 VWC2 VWC2 SFRP4 SFRP4 TBX20 TBX20 BMPER BMPER LEMD2 LEMD2 FST FST PELO PELO SFRP2 SFRP2 KDR KDR HTRA3 HTRA3 GDF5 GDF5 VWC2L VWC2L LRP2 LRP2 FKBP8 FKBP8 DAND5 DAND5 FSTL3 FSTL3 SMAD4 SMAD4 SMAD7 SMAD7 RNF165 RNF165 GATA6 GATA6 TWSG1 TWSG1 UBE2O UBE2O NOG NOG ITGA3 ITGA3 SOST SOST CDH5 CDH5 ZNF423 ZNF423 NEO1 NEO1 SKOR1 SKOR1 SMAD6 SMAD6 RBPMS2 RBPMS2 PPM1A PPM1A BMP4 BMP4 LEMD3 LEMD3 ACVRL1 ACVRL1 WNT1 WNT1 GDF3 GDF3 SORL1 SORL1 HTRA1 HTRA1 DKK1 DKK1 BAMBI BAMBI TRIM33 TRIM33 CCN1 CCN1 SKI SKI TFAP2B TFAP2B ENSPTRP00000079019 ENSPTRP00000079019 RBPJ RBPJ HES5-2 HES5-2 BMP4-2 BMP4-2 CHRDL1 CHRDL1 HJV HJV CHRD CHRD WNT5A WNT5A KCP KCP FZD1 FZD1 SMURF2 SMURF2 SOSTDC1-2 SOSTDC1-2 CRIM1 CRIM1 GREM2 GREM2 SOX11 SOX11 FOXD1 FOXD1 FZD1-2 FZD1-2 NUMA1 NUMA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
GATA4GATA binding protein 4. (443 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
CTDSPL2CTD (Carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2. (466 aa)
UBE2D3Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (901 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
SKILSKI like proto-oncogene. (684 aa)
SKOR2SKI family transcriptional corepressor 2. (1012 aa)
CHRDL2CHRDL2 isoform 2. (452 aa)
NBL1Neuroblastoma suppressor of tumorigenicity 1. (216 aa)
GDF2GDF2 isoform 1. (429 aa)
FBN1FBN1 isoform 1. (2871 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
SFRP5Secreted frizzled related protein 5. (317 aa)
ILKIntegrin-linked kinase. (533 aa)
FBXL15F-box and leucine-rich repeat protein 15. (300 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
HOXA13Homeobox A13. (388 aa)
ENSPTRP00000063212annotation not available (75 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TMPRSS6TMPRSS6 isoform 2; Belongs to the peptidase S1 family. (824 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
ENSPTRP00000061118annotation not available (140 aa)
KIAA1324LKIAA1324L isoform 1. (1029 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (993 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
TNFAIP6Tumor necrosis factor, alpha-induced protein 6. (277 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
HOXA13-2HOXA13 isoform 1. (388 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
PCSK6PCSK6 isoform 3; Belongs to the peptidase S8 family. (968 aa)
CRB2CRB2 isoform 1. (1285 aa)
SPARTSpastic paraplegia 20 (Troyer syndrome). (665 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
DLX1Distal-less homeobox 1. (255 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ENGENG isoform 1. (658 aa)
CER1CER1 isoform 1. (267 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
SFRP4SFRP4 isoform 1. (368 aa)
TBX20T-box transcription factor 20. (447 aa)
BMPERBMP binding endothelial regulator. (685 aa)
LEMD2LEM domain containing 2. (503 aa)
FSTFST isoform 1. (344 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
HTRA3HtrA serine peptidase 3. (402 aa)
GDF5GDF5 isoform 1. (501 aa)
VWC2LVon Willebrand factor C domain containing 2 like. (222 aa)
LRP2LRP2 isoform 1. (4655 aa)
FKBP8Peptidylprolyl isomerase. (413 aa)
DAND5DAN domain BMP antagonist family member 5. (189 aa)
FSTL3Follistatin-like 3 (Secreted glycoprotein). (263 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
RNF165Ring finger protein 165. (346 aa)
GATA6GATA binding protein 6. (594 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1292 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ITGA3ITGA3 isoform 6; Belongs to the integrin alpha chain family. (1066 aa)
SOSTSOST isoform 1. (213 aa)
CDH5CDH5 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
ZNF423Zinc finger protein 423. (1284 aa)
NEO1NEO1 isoform 2. (1461 aa)
SKOR1SKI family transcriptional corepressor 1. (962 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (209 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
LEMD3LEM domain containing 3. (911 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
GDF3Growth differentiation factor 3. (364 aa)
SORL1Sortilin related receptor 1. (2214 aa)
HTRA1HtrA serine peptidase 1. (522 aa)
DKK1Dickkopf-like protein 1. (289 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
TRIM33Tripartite motif containing 33. (1127 aa)
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
SKIV-ski sarcoma viral oncogene homolog (Avian). (736 aa)
TFAP2BTranscription factor AP-2 beta. (467 aa)
ENSPTRP00000079019annotation not available (165 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
CHRDL1CHRDL1 isoform 3. (458 aa)
HJVHFE2 isoform 1. (426 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (955 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
KCPKielin cysteine rich BMP regulator. (1628 aa)
FZD1FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
SMURF2E3 ubiquitin-protein ligase. (744 aa)
SOSTDC1-2Sclerostin domain containing 1. (206 aa)
CRIM1CRIM1 isoform 1. (1036 aa)
GREM2Gremlin. (168 aa)
SOX11Transcription factor SOX. (441 aa)
FOXD1FOXD1 isoform 1. (439 aa)
FZD1-2Frizzled class receptor 1. (580 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2111 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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