STRINGSTRING
ENG ENG NOTCH1 NOTCH1 HES5 HES5 CRB2 CRB2 MSX1 MSX1 BMPR2 BMPR2 SCUBE3 SCUBE3 KIAA1324L KIAA1324L SMAD2 SMAD2 HES1 HES1 FBXL15 FBXL15 NUMA1 NUMA1 FOXD1 FOXD1 SOX11 SOX11 KCP KCP BMP4-2 BMP4-2 HES5-2 HES5-2 RBPJ RBPJ GATA4 GATA4 NOTCH2 NOTCH2 SULF1 SULF1 GDF2 GDF2 ILK ILK CCN1 CCN1 ACVRL1 ACVRL1 BMP4 BMP4 NEO1 NEO1 ZNF423 ZNF423 CDH5 CDH5 UBE2O UBE2O TWSG1 TWSG1 GATA6 GATA6 RNF165 RNF165 SMAD4 SMAD4 FKBP8 FKBP8 GDF5 GDF5 KDR KDR PELO PELO TBX20 TBX20
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENGENG isoform 1. (658 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
CRB2CRB2 isoform 1. (1285 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (993 aa)
KIAA1324LKIAA1324L isoform 1. (1029 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
FBXL15F-box and leucine-rich repeat protein 15. (300 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2111 aa)
FOXD1FOXD1 isoform 1. (439 aa)
SOX11Transcription factor SOX. (441 aa)
KCPKielin cysteine rich BMP regulator. (1628 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
GATA4GATA binding protein 4. (443 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (901 aa)
GDF2GDF2 isoform 1. (429 aa)
ILKIntegrin-linked kinase. (533 aa)
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
NEO1NEO1 isoform 2. (1461 aa)
ZNF423Zinc finger protein 423. (1284 aa)
CDH5CDH5 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1292 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
GATA6GATA binding protein 6. (594 aa)
RNF165Ring finger protein 165. (346 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FKBP8Peptidylprolyl isomerase. (413 aa)
GDF5GDF5 isoform 1. (501 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
TBX20T-box transcription factor 20. (447 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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