59 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	UBE2D3	Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
	ENSPTRP00000079019	annotation not available (165 aa)
	CHRDL1	CHRDL1 isoform 3. (458 aa)
	HJV	HFE2 isoform 1. (426 aa)
	CHRD	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (955 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	FZD1	FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
	SMURF2	E3 ubiquitin-protein ligase. (744 aa)
	SOSTDC1-2	Sclerostin domain containing 1. (206 aa)
	CRIM1	CRIM1 isoform 1. (1036 aa)
	GREM2	Gremlin. (168 aa)
	FZD1-2	Frizzled class receptor 1. (580 aa)
	VWC2	Von Willebrand factor C domain containing 2. (325 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1198 aa)
	CER1	CER1 isoform 1. (267 aa)
	NOTCH1	NOTCH1 isoform 1. (2555 aa)
	DLX1	Distal-less homeobox 1. (255 aa)
	SPART	Spastic paraplegia 20 (Troyer syndrome). (665 aa)
	SMURF1	E3 ubiquitin-protein ligase. (757 aa)
	TNFAIP6	Tumor necrosis factor, alpha-induced protein 6. (277 aa)
	SFRP1	Secreted frizzled-related protein 1. (314 aa)
	ENSPTRP00000061118	annotation not available (140 aa)
	CK820_G0012168	ABL1 isoform 3. (1149 aa)
	TMPRSS6	TMPRSS6 isoform 2; Belongs to the peptidase S1 family. (824 aa)
	ENSPTRP00000063212	annotation not available (75 aa)
	SOSTDC1	Sclerostin domain containing 1. (230 aa)
	FBN1	FBN1 isoform 1. (2871 aa)
	NBL1	Neuroblastoma suppressor of tumorigenicity 1. (216 aa)
	CHRDL2	CHRDL2 isoform 2. (452 aa)
	SKOR2	SKI family transcriptional corepressor 2. (1012 aa)
	SKIL	SKI like proto-oncogene. (684 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	BMPER	BMP binding endothelial regulator. (685 aa)
	LEMD2	LEM domain containing 2. (503 aa)
	SFRP2	Secreted frizzled-related protein 2. (295 aa)
	HTRA3	HtrA serine peptidase 3. (402 aa)
	VWC2L	Von Willebrand factor C domain containing 2 like. (222 aa)
	LRP2	LRP2 isoform 1. (4655 aa)
	DAND5	DAN domain BMP antagonist family member 5. (189 aa)
	FSTL3	Follistatin-like 3 (Secreted glycoprotein). (263 aa)
	SMAD7	Mothers against decapentaplegic homolog. (491 aa)
	TWSG1	Twisted gastrulation BMP signaling modulator 1. (223 aa)
	SOST	SOST isoform 1. (213 aa)
	SKOR1	SKI family transcriptional corepressor 1. (962 aa)
	SMAD6	Mothers against decapentaplegic homolog. (496 aa)
	RBPMS2	RNA binding protein, mRNA processing factor 2. (209 aa)
	PPM1A	Protein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
	LEMD3	LEM domain containing 3. (911 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	GDF3	Growth differentiation factor 3. (364 aa)
	SORL1	Sortilin related receptor 1. (2214 aa)
	HTRA1	HtrA serine peptidase 1. (522 aa)
	DKK1	Dickkopf-like protein 1. (289 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
	TRIM33	Tripartite motif containing 33. (1127 aa)
	SKI	V-ski sarcoma viral oncogene homolog (Avian). (736 aa)
	CTDSPL2	CTD (Carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2. (466 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma isoform X2. (505 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	NOTCH1	ENSPTRP00000072918	ENSPTRP00000036924	Tyrosine-protein kinase.	NOTCH1 isoform 1.	0.477
BAMBI	FZD1	ENSPTRP00000004049	ENSPTRP00000087775	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.906
BAMBI	SMAD6	ENSPTRP00000004049	ENSPTRP00000012318	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.743
BAMBI	SMAD7	ENSPTRP00000004049	ENSPTRP00000017016	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.956
BAMBI	SOST	ENSPTRP00000004049	ENSPTRP00000015741	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	SOST isoform 1.	0.534
BMPER	CHRD	ENSPTRP00000032587	ENSPTRP00000086110	BMP binding endothelial regulator.	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	0.655
BMPER	CHRDL2	ENSPTRP00000032587	ENSPTRP00000069377	BMP binding endothelial regulator.	CHRDL2 isoform 2.	0.627
BMPER	NOG	ENSPTRP00000032587	ENSPTRP00000016018	BMP binding endothelial regulator.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.412
BMPER	SOST	ENSPTRP00000032587	ENSPTRP00000015741	BMP binding endothelial regulator.	SOST isoform 1.	0.508
BMPER	TWSG1	ENSPTRP00000032587	ENSPTRP00000016778	BMP binding endothelial regulator.	Twisted gastrulation BMP signaling modulator 1.	0.499
CER1	DAND5	ENSPTRP00000035539	ENSPTRP00000018013	CER1 isoform 1.	DAN domain BMP antagonist family member 5.	0.882
CER1	DKK1	ENSPTRP00000035539	ENSPTRP00000004327	CER1 isoform 1.	Dickkopf-like protein 1.	0.404
CER1	GDF3	ENSPTRP00000035539	ENSPTRP00000007883	CER1 isoform 1.	Growth differentiation factor 3.	0.472
CER1	WNT1	ENSPTRP00000035539	ENSPTRP00000008364	CER1 isoform 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.901
CER1	WNT5A	ENSPTRP00000035539	ENSPTRP00000086163	CER1 isoform 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.905
CHRD	BMPER	ENSPTRP00000086110	ENSPTRP00000032587	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	BMP binding endothelial regulator.	0.655
CHRD	DKK1	ENSPTRP00000086110	ENSPTRP00000004327	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Dickkopf-like protein 1.	0.439
CHRD	NOG	ENSPTRP00000086110	ENSPTRP00000016018	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.752
CHRD	SMAD6	ENSPTRP00000086110	ENSPTRP00000012318	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Mothers against decapentaplegic homolog.	0.491
CHRD	SOST	ENSPTRP00000086110	ENSPTRP00000015741	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	SOST isoform 1.	0.604