STRINGSTRING
CHRNB2 CHRNB2 DRD4 DRD4 BBS1 BBS1 FADD FADD SHANK2 SHANK2 CCND2 CCND2 EPS8 EPS8 HTR2A HTR2A SLITRK1 SLITRK1 SLITRK5 SLITRK5 UNC79 UNC79 CHRNA5 CHRNA5 CHRNB4 CHRNB4 HOMER2 HOMER2 ABAT ABAT NTAN1 NTAN1 BBS2 BBS2 AGRP AGRP CTNS CTNS ARRB2 ARRB2 CHRNB1 CHRNB1 SEZ6 SEZ6 PPP1R1B PPP1R1B CNP CNP GIP GIP LGI4 LGI4 NTF4 NTF4 ALK ALK ATP6V1B1 ATP6V1B1 SCN1A SCN1A HOXD10 HOXD10 CK820_G0037244 CK820_G0037244 PPARA PPARA OPRD1 OPRD1 CHL1 CHL1 TRH TRH GHSR GHSR RNF180 RNF180 CRHBP CRHBP GLRA1 GLRA1 PRKN PRKN SDK1 SDK1 HIPK2 HIPK2 GBX1 GBX1 CHRNA6 CHRNA6 CHD7 CHD7 DMRT3 DMRT3 DBH DBH KLHL4 KLHL4 BRS3 BRS3 TMOD1 TMOD1 NLGN4X NLGN4X SPTBN2 SPTBN2 OPRM1 OPRM1 INPP5F INPP5F NRXN3 NRXN3 DMBX1 DMBX1 CARTPT CARTPT CEND1 CEND1 EN1 EN1 PAX5 PAX5 SLC1A1 SLC1A1 HDAC2 HDAC2 BTBD9 BTBD9 EHMT2 EHMT2 GRM2 GRM2 DAB1 DAB1 ZFHX2 ZFHX2 NLGN2 NLGN2 PCDH17 PCDH17 OTOG OTOG ADAM22 ADAM22 CACNB4 CACNB4 BBS4 BBS4 SLITRK6 SLITRK6 GABRG2 GABRG2 TBCE TBCE DRD3 DRD3 ADAM2 ADAM2 ENSPTRP00000063424 ENSPTRP00000063424 CK820_G0054728 CK820_G0054728 SHANK3 SHANK3 TSC1 TSC1 GRIN2D GRIN2D CNTNAP2 CNTNAP2 ENSPTRP00000065012 ENSPTRP00000065012 KLHL5 KLHL5 DRD1 DRD1 SHANK1 SHANK1 SLC1A2 SLC1A2 PBX3 PBX3 SEPTIN5 SEPTIN5 CXCL12 CXCL12 SLC7A11 SLC7A11 AGTPBP1 AGTPBP1 ZIC1 ZIC1 DRD2 DRD2 NLGN3 NLGN3 ABHD12 ABHD12 ENSPTRP00000070307 ENSPTRP00000070307 ENSPTRP00000070863 ENSPTRP00000070863 ENSPTRP00000070902 ENSPTRP00000070902 PUM1 PUM1 GLRB GLRB LEP LEP ENSPTRP00000072952 ENSPTRP00000072952 NRXN1 NRXN1 HTRA2 HTRA2 OXR1 OXR1 PREX2 PREX2 CLN8 CLN8 SPTBN4 SPTBN4 NRXN2 NRXN2 ENSPTRP00000077189 ENSPTRP00000077189 GHRL GHRL PAFAH1B1 PAFAH1B1 PARK7 PARK7 CHRNA3 CHRNA3 ARCN1 ARCN1 TPGS1 TPGS1 PCDH15 PCDH15 OXR1-2 OXR1-2 HOXD9 HOXD9 CDK5 CDK5 ZMPSTE24 ZMPSTE24 NPC1 NPC1 SEZ6L2 SEZ6L2 ENSPTRP00000081136 ENSPTRP00000081136 MECP2 MECP2 ATP1A2 ATP1A2 FXN FXN HOMER1 HOMER1 KALRN KALRN CNTN2 CNTN2 EPHA4 EPHA4 SNCG SNCG CSTB CSTB CLCN3 CLCN3 EFNB3 EFNB3 CHRNA4 CHRNA4 NTAN1-2 NTAN1-2 KLHL1 KLHL1 USP46 USP46 NR4A2 NR4A2 HOXB8 HOXB8 CELF6-2 CELF6-2 FGF12 FGF12 FOXA2 FOXA2 ADAM22-2 ADAM22-2 PTEN PTEN MAFG MAFG SNCA SNCA TSHR TSHR ENSPTRP00000093022 ENSPTRP00000093022 PPT1 PPT1 UCHL1 UCHL1 NCSTN NCSTN APP APP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHRNB2CHRNB2 isoform 2. (502 aa)
DRD4DRD4 isoform 1; Belongs to the G-protein coupled receptor 1 family. (415 aa)
BBS1Bardet-Biedl syndrome 1 protein isoform X1. (593 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1849 aa)
CCND2CCND2 isoform 1; Belongs to the cyclin family. (289 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (822 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
SLITRK1SLITRK1 isoform 1. (580 aa)
SLITRK5SLIT and NTRK like family member 5. (958 aa)
UNC79UNC79 isoform 1. (2648 aa)
CHRNA5Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (468 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (498 aa)
HOMER2Homer scaffold protein 2. (356 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (515 aa)
NTAN1N-terminal asparagine amidase. (310 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
AGRPAgouti related neuropeptide. (132 aa)
CTNSCystinosin, lysosomal cystine transporter. (400 aa)
ARRB2ARRB2 isoform 2. (430 aa)
CHRNB1Cholinergic receptor, nicotinic, beta 1 (Muscle). (501 aa)
SEZ6Seizure related 6 homolog. (994 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (203 aa)
CNP2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (421 aa)
GIPGastric inhibitory polypeptide. (153 aa)
LGI4Leucine rich repeat LGI family member 4. (537 aa)
NTF4NTF4 isoform 1; Belongs to the NGF-beta family. (210 aa)
ALKTyrosine-protein kinase receptor. (1620 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2009 aa)
HOXD10Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (410 aa)
CK820_G0037244NTSR1 isoform 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (467 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
CHL1Cell adhesion molecule with homology to L1CAM (Close homolog of L1). (1225 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (240 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
RNF180Ring finger protein 180. (592 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
GLRA1GLRA1 isoform 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (451 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
SDK1SDK1 isoform 1. (2007 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
GBX1Gastrulation brain homeobox 1. (363 aa)
CHRNA6Neuronal acetylcholine receptor subunit alpha-6; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (494 aa)
CHD7CHD7 isoform 1. (2997 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (472 aa)
DBHDopamine beta-hydroxylase. (617 aa)
KLHL4Kelch like family member 4. (718 aa)
BRS3Bombesin receptor subtype 3; Belongs to the G-protein coupled receptor 1 family. (399 aa)
TMOD1TMOD1 isoform 1. (359 aa)
NLGN4XNeuroligin 4 X-linked. (817 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2390 aa)
OPRM1Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] (476 aa)
INPP5FInositol polyphosphate-5-phosphatase F. (1133 aa)
NRXN3NRXN3 isoform 1. (1664 aa)
DMBX1Diencephalon/mesencephalon homeobox 1. (377 aa)
CARTPTCART prepropeptide. (116 aa)
CEND1Cell cycle exit and neuronal differentiation 1. (149 aa)
EN1Homeobox protein engrailed-like. (396 aa)
PAX5PAX5 isoform 1. (391 aa)
SLC1A1Amino acid transporter. (524 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
BTBD9BTB (POZ) domain containing 9. (612 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1267 aa)
GRM2Glutamate metabotropic receptor 2. (872 aa)
DAB1DAB adaptor protein 1. (588 aa)
ZFHX2ZFHX2 isoform 1. (2572 aa)
NLGN2NLGN2 isoform 1. (836 aa)
PCDH17PCDH17 isoform 1. (1187 aa)
OTOGOTOG isoform 2. (2925 aa)
ADAM22ADAM metallopeptidase domain 22. (906 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa)
BBS4Bardet-Biedl syndrome 4. (519 aa)
SLITRK6SLITRK6 isoform 1. (841 aa)
GABRG2Gamma-aminobutyric acid type A receptor gamma2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (515 aa)
TBCETBCE isoform 2. (566 aa)
DRD3D(3) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation (By similarity). (400 aa)
ADAM2ADAM2 isoform 1. (735 aa)
ENSPTRP00000063424annotation not available (1563 aa)
CK820_G0054728MECP2 isoform 14. (493 aa)
SHANK3SHANK3 isoform 2. (1744 aa)
TSC1TSC complex subunit 1. (1164 aa)
GRIN2DGRIN2D isoform 1. (1265 aa)
CNTNAP2Contactin associated protein like 2. (1331 aa)
ENSPTRP00000065012annotation not available (108 aa)
KLHL5Kelch like family member 5. (757 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
SHANK1SHANK1 isoform 3. (2161 aa)
SLC1A2Amino acid transporter. (574 aa)
PBX3PBX homeobox 3. (455 aa)
SEPTIN5SEPT5 isoform 5; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (378 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
SLC7A11Solute carrier family 7, (Cationic amino acid transporter, y+ system) member 11. (515 aa)
AGTPBP1ATP/GTP binding protein 1. (1290 aa)
ZIC1Zic family member 1. (447 aa)
DRD2D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (490 aa)
NLGN3NLGN3 isoform 5. (848 aa)
ABHD12Abhydrolase domain containing 12. (404 aa)
ENSPTRP00000070307annotation not available (237 aa)
ENSPTRP00000070863annotation not available (261 aa)
ENSPTRP00000070902annotation not available (168 aa)
PUM1PUM1 isoform 1. (1216 aa)
GLRBGlycine receptor, beta; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (497 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
ENSPTRP00000072952annotation not available (212 aa)
NRXN1NRXN1 isoform 9. (1547 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
OXR1OXR1 isoform 3. (872 aa)
PREX2Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1620 aa)
CLN8Ceroid-lipofuscinosis neuronal protein 8. (286 aa)
SPTBN4Spectrin beta, non-erythrocytic 4. (2565 aa)
NRXN2NRXN2 isoform 2. (1712 aa)
ENSPTRP00000077189annotation not available (276 aa)
GHRLGHRL isoform 10. (117 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (413 aa)
PARK7PARK7 isoform 1. (189 aa)
CHRNA3Cholinergic receptor nicotinic alpha 3 subunit. (503 aa)
ARCN1Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (552 aa)
TPGS1Tubulin polyglutamylase complex subunit 1. (290 aa)
PCDH15Protocadherin related 15. (1954 aa)
OXR1-2Oxidation resistance 1. (198 aa)
HOXD9HOXD9 isoform 1. (356 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
NPC1Niemann-Pick disease, type C1. (1280 aa)
SEZ6L2Seizure related 6 homolog-like 2. (923 aa)
ENSPTRP00000081136LOW QUALITY PROTEIN: uncharacterized protein LOC100614654. (148 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
FXNFXN isoform 1. (210 aa)
HOMER1HOMER1 isoform 1. (344 aa)
KALRNKalirin RhoGEF kinase. (2986 aa)
CNTN2CNTN2 isoform 13. (1040 aa)
EPHA4EPH receptor A4. (986 aa)
SNCGGamma-synuclein; Belongs to the synuclein family. (170 aa)
CSTBCystatin-B; This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B (By similarity). (98 aa)
CLCN3Chloride channel protein. (866 aa)
EFNB3EFNB3 isoform 1; Belongs to the ephrin family. (340 aa)
CHRNA4Neuronal acetylcholine receptor subunit alpha-4; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. (640 aa)
NTAN1-2N-terminal asparagine amidase. (310 aa)
KLHL1Kelch like family member 1. (748 aa)
USP46Ubiquitin specific peptidase 46; Belongs to the peptidase C19 family. (368 aa)
NR4A2Nuclear receptor subfamily 4, group A, member 2. (598 aa)
HOXB8HOXB8 isoform 1. (243 aa)
CELF6-2CUGBP Elav-like family member 6 isoform X1. (538 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
FOXA2FOXA2 isoform 1. (464 aa)
ADAM22-2ADAM22 isoform 3. (923 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MAFGV-maf musculoaponeurotic fibrosarcoma oncogene homolog G (Avian). (162 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
ENSPTRP00000093022annotation not available (563 aa)
PPT1Palmitoyl-protein thioesterase 1. (335 aa)
UCHL1Ubiquitin carboxyl-terminal hydrolase. (260 aa)
NCSTNNCSTN isoform 1. (721 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (771 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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