STRINGSTRING
WNT9B-2 WNT9B-2 SHH SHH FGF8 FGF8 HSD17B3 HSD17B3 GREB1L GREB1L GREB1 GREB1 LHCGR LHCGR HOXD13 HOXD13 SRD5A1 SRD5A1 BMP6 BMP6 BMP5 BMP5 ASB1 ASB1 ROR2 ROR2 SYCP2 SYCP2 CTNNB1 CTNNB1 HOXA13-2 HOXA13-2 WNT9B WNT9B TBX3 TBX3 HOXA13 HOXA13 DHCR24 DHCR24 KLHL10 KLHL10 LGR4 LGR4 WT1 WT1 SRD5A2 SRD5A2 FGF10 FGF10 LOC107971060 LOC107971060 AR AR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT9B-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
HSD17B3Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (310 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1967 aa)
GREB1Growth regulating estrogen receptor binding 1. (1949 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (699 aa)
HOXD13HOXD13 isoform 1. (344 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (259 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
ASB1Ankyrin repeat and SOCS box containing 1. (336 aa)
ROR2Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (943 aa)
SYCP2Synaptonemal complex protein 2. (1530 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
HOXA13-2HOXA13 isoform 1. (388 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
TBX3T-box transcription factor 3. (743 aa)
HOXA13Homeobox A13. (388 aa)
DHCR2424-dehydrocholesterol reductase. (516 aa)
KLHL10Kelch like family member 10. (608 aa)
LGR4LGR4 isoform 2. (951 aa)
WT1WT1 transcription factor. (514 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LOC107971060SRD5A1 isoform 2. (141 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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