node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AR | CTNNB1 | ENSPTRP00000076864 | ENSPTRP00000044466 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Catenin (Cadherin-associated protein), beta 1, 88kDa. | 0.960 |
AR | HSD17B3 | ENSPTRP00000076864 | ENSPTRP00000073561 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.471 |
AR | SRD5A1 | ENSPTRP00000076864 | ENSPTRP00000028677 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. | 0.458 |
AR | SRD5A2 | ENSPTRP00000076864 | ENSPTRP00000085115 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. | 0.664 |
CTNNB1 | AR | ENSPTRP00000044466 | ENSPTRP00000076864 | Catenin (Cadherin-associated protein), beta 1, 88kDa. | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | 0.960 |
CTNNB1 | FGF10 | ENSPTRP00000044466 | ENSPTRP00000083399 | Catenin (Cadherin-associated protein), beta 1, 88kDa. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.512 |
CTNNB1 | FGF8 | ENSPTRP00000044466 | ENSPTRP00000075677 | Catenin (Cadherin-associated protein), beta 1, 88kDa. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.633 |
CTNNB1 | LGR4 | ENSPTRP00000044466 | ENSPTRP00000093566 | Catenin (Cadherin-associated protein), beta 1, 88kDa. | LGR4 isoform 2. | 0.532 |
CTNNB1 | ROR2 | ENSPTRP00000044466 | ENSPTRP00000036064 | Catenin (Cadherin-associated protein), beta 1, 88kDa. | Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. | 0.450 |
CTNNB1 | SHH | ENSPTRP00000044466 | ENSPTRP00000075730 | Catenin (Cadherin-associated protein), beta 1, 88kDa. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.720 |
CTNNB1 | WNT9B | ENSPTRP00000044466 | ENSPTRP00000059920 | Catenin (Cadherin-associated protein), beta 1, 88kDa. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.489 |
CTNNB1 | WNT9B-2 | ENSPTRP00000044466 | ENSPTRP00000076242 | Catenin (Cadherin-associated protein), beta 1, 88kDa. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.489 |
CTNNB1 | WT1 | ENSPTRP00000044466 | ENSPTRP00000087673 | Catenin (Cadherin-associated protein), beta 1, 88kDa. | WT1 transcription factor. | 0.497 |
DHCR24 | HSD17B3 | ENSPTRP00000001349 | ENSPTRP00000073561 | 24-dehydrocholesterol reductase. | Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.506 |
FGF10 | CTNNB1 | ENSPTRP00000083399 | ENSPTRP00000044466 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Catenin (Cadherin-associated protein), beta 1, 88kDa. | 0.512 |
FGF10 | FGF8 | ENSPTRP00000083399 | ENSPTRP00000075677 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.549 |
FGF10 | SHH | ENSPTRP00000083399 | ENSPTRP00000075730 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.809 |
FGF10 | TBX3 | ENSPTRP00000083399 | ENSPTRP00000084833 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | T-box transcription factor 3. | 0.544 |
FGF8 | CTNNB1 | ENSPTRP00000075677 | ENSPTRP00000044466 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Catenin (Cadherin-associated protein), beta 1, 88kDa. | 0.633 |
FGF8 | FGF10 | ENSPTRP00000075677 | ENSPTRP00000083399 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.549 |