STRINGSTRING
VASP VASP PFN2 PFN2 ADD1 ADD1 RASA1 RASA1 FER FER CARMIL1 CARMIL1 ARHGAP18 ARHGAP18 LATS1 LATS1 SCIN SCIN DBNL DBNL CCL26 CCL26 CCL24 CCL24 ARPC1A ARPC1A ARPC1B ARPC1B PTK2B PTK2B BAG4 BAG4 ARFGEF1 ARFGEF1 FAM49B FAM49B CCL21 CCL21 GBA2 GBA2 ABITRAM ABITRAM GSN GSN ARPC5L ARPC5L TENM1 TENM1 TMSB15A TMSB15A CSF3 CSF3 TMOD1 TMOD1 BAIAP2L1 BAIAP2L1 DMTN DMTN SPTBN2 SPTBN2 KANK1 KANK1 MTPN MTPN FCHSD1 FCHSD1 ADD3 ADD3 KIRREL1 KIRREL1 TMSB4X TMSB4X LMOD2 LMOD2 CAPZA2 CAPZA2 CDC42EP5 CDC42EP5 ARHGAP28 ARHGAP28 TMSB10 TMSB10 KANK4 KANK4 SPTB SPTB CCR7 CCR7 HIP1R HIP1R LOC472932 LOC472932 DBNL-2 DBNL-2 ENSPTRP00000078387 ENSPTRP00000078387 ENSPTRP00000078893 ENSPTRP00000078893 SSH3 SSH3 ADD2 ADD2 SLIT2 SLIT2 FHOD3 FHOD3 CK820_G0029270 CK820_G0029270 LOC104001050 LOC104001050 ELN ELN ENSPTRP00000081955 ENSPTRP00000081955 CK820_G0015929 CK820_G0015929 LOC107971086 LOC107971086 CTTN CTTN KIAA1211 KIAA1211 FLII FLII ENSPTRP00000083809 ENSPTRP00000083809 ARPC4 ARPC4 ENSPTRP00000085116 ENSPTRP00000085116 ENSPTRP00000085141 ENSPTRP00000085141 ENSPTRP00000085830 ENSPTRP00000085830 ENSPTRP00000086247 ENSPTRP00000086247 DBN1 DBN1 BAIAP2L1-2 BAIAP2L1-2 ENSPTRP00000088582 ENSPTRP00000088582 ARPC2 ARPC2 SSH1 SSH1 ENSPTRP00000090995 ENSPTRP00000090995 NCK1 NCK1 ENSPTRP00000091405 ENSPTRP00000091405 TMOD2 TMOD2 MYADM MYADM CARMIL2 CARMIL2 SCIN-2 SCIN-2 ENSPTRP00000092498 ENSPTRP00000092498 FCHSD2 FCHSD2 CCL11 CCL11 CDC42EP3 CDC42EP3 BBS4 BBS4 CAPZA1 CAPZA1 TRIOBP TRIOBP PLEKHG2 PLEKHG2 NPHS1 NPHS1 ENSPTRP00000062048 ENSPTRP00000062048 ENSPTRP00000062137 ENSPTRP00000062137 PAK3 PAK3 PFN3 PFN3 FMN1 FMN1 CYFIP2 CYFIP2 BAIAP2 BAIAP2 SPTAN1 SPTAN1 SNX9 SNX9 ENSPTRP00000065871 ENSPTRP00000065871 ENSPTRP00000066549 ENSPTRP00000066549 DLG1 DLG1 ENSPTRP00000066855 ENSPTRP00000066855 COTL1 COTL1 KANK3 KANK3 ENSPTRP00000067474 ENSPTRP00000067474 RICTOR RICTOR C15H15orf62 C15H15orf62 SPTBN5 SPTBN5 TMSB4Y TMSB4Y SPTBN4 SPTBN4 ARPC3 ARPC3 CDC42EP2 CDC42EP2 TWF1 TWF1 DAAM2 DAAM2 ENSPTRP00000073763 ENSPTRP00000073763 ENSPTRP00000073520 ENSPTRP00000073520 RDX RDX CAPZB CAPZB CCL24-2 CCL24-2 SPTBN1 SPTBN1 ENSPTRP00000070693 ENSPTRP00000070693 ENSPTRP00000070303 ENSPTRP00000070303 MLST8 MLST8 ARF6 ARF6 ENSPTRP00000069497 ENSPTRP00000069497 ENSPTRP00000067847 ENSPTRP00000067847 MTOR MTOR TMSB4X-2 TMSB4X-2 TMOD4 TMOD4 HAX1 HAX1 SPTA1 SPTA1 ARPC5 ARPC5 LMOD1 LMOD1 SVIL SVIL ESAM ESAM EPS8 EPS8 CAPZA3 CAPZA3 NCKAP1L NCKAP1L AVIL AVIL EVL EVL CYFIP1 CYFIP1 TMOD3 TMOD3 CORO1A CORO1A PYCARD PYCARD ALOX15 ALOX15 PFN1 PFN1 SSH2 SSH2 GRB2 GRB2 PIK3R2 PIK3R2 FAM49A FAM49A PFN4 PFN4 PRKCE PRKCE CAPG CAPG NCK2 NCK2 BIN1 BIN1 NCKAP1 NCKAP1 VIL1 VIL1 MKKS MKKS HCK HCK ARHGAP40 ARHGAP40 CDC42EP1 CDC42EP1 BAIAP2L2 BAIAP2L2 VILL VILL RHOA RHOA TWF2 TWF2 PRKCD PRKCD LMOD3 LMOD3 HCLS1 HCLS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VASPVasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
PFN2Profilin; Belongs to the profilin family. (188 aa)
ADD1ADD1 isoform 5. (768 aa)
RASA1RAS p21 protein activator (GTPase activating protein) 1. (1047 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
CARMIL1Capping protein regulator and myosin 1 linker 1. (1371 aa)
ARHGAP18Rho GTPase activating protein 18. (663 aa)
LATS1LATS, large tumor suppressor, homolog 1. (1130 aa)
SCINSCIN isoform 3. (715 aa)
DBNLDBNL isoform 5. (439 aa)
CCL26C-C motif chemokine. (94 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
ARPC1BActin related protein 2/3 complex, subunit 1A/1B. (372 aa)
PTK2BPTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
BAG4BCL2-associated athanogene 4. (457 aa)
ARFGEF1ADP-ribosylation factor guanine nucleotide-exchange factor 1(Brefeldin A-inhibited). (1849 aa)
FAM49BFAM49B isoform 13. (324 aa)
CCL21C-C motif chemokine ligand 21. (134 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (927 aa)
ABITRAMFAM206A isoform 2. (181 aa)
GSNGSN isoform 3. (782 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
TENM1Teneurin transmembrane protein 1. (2732 aa)
TMSB15AThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
CSF3Colony stimulating factor 3 (Granulocyte). (204 aa)
TMOD1TMOD1 isoform 1. (359 aa)
BAIAP2L1BAI1-associated protein 2-like 1. (511 aa)
DMTNDematin actin binding protein. (405 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2390 aa)
KANK1KANK1 isoform 8. (1345 aa)
MTPNMTPN isoform 1. (118 aa)
FCHSD1FCH and double SH3 domains 1. (690 aa)
ADD3Adducin 3 (Gamma). (706 aa)
KIRREL1Kirre like nephrin family adhesion molecule 1. (757 aa)
TMSB4XThymosin beta 4 X-linked. (44 aa)
LMOD2LMOD2 isoform 1. (548 aa)
CAPZA2F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). (286 aa)
CDC42EP5CDC42 effector protein (Rho GTPase binding) 5. (148 aa)
ARHGAP28Rho GTPase activating protein 28. (729 aa)
TMSB10Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
KANK4KN motif and ankyrin repeat domains 4. (995 aa)
SPTBSpectrin beta chain; Belongs to the spectrin family. (2265 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
HIP1RHuntingtin interacting protein 1 related. (1068 aa)
LOC472932BCL2 associated athanogene 4 pseudogene. (356 aa)
DBNL-2Drebrin like. (439 aa)
ENSPTRP00000078387annotation not available (202 aa)
ENSPTRP00000078893annotation not available (168 aa)
SSH3Slingshot protein phosphatase 3. (658 aa)
ADD2ADD2 isoform 1. (726 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
FHOD3Formin homology 2 domain containing 3. (1622 aa)
CK820_G0029270IQANK1 isoform 1. (91 aa)
LOC104001050Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
ELNELN isoform 3. (790 aa)
ENSPTRP00000081955annotation not available (66 aa)
CK820_G0015929ARPC3 isoform 3. (178 aa)
LOC107971086Thymosin beta-15A isoform X2. (45 aa)
CTTNCTTN isoform 2. (634 aa)
KIAA1211KIAA1211 isoform 3. (1233 aa)
FLIIFLII actin remodeling protein. (1273 aa)
ENSPTRP00000083809annotation not available (152 aa)
ARPC4Actin-related protein 2/3 complex subunit 4 isoform X4. (173 aa)
ENSPTRP00000085116annotation not available (227 aa)
ENSPTRP00000085141annotation not available (333 aa)
ENSPTRP00000085830annotation not available (168 aa)
ENSPTRP00000086247annotation not available (513 aa)
DBN1DBN1 isoform 1. (695 aa)
BAIAP2L1-2BAR/IMD domain containing adaptor protein 2 like 1. (502 aa)
ENSPTRP00000088582annotation not available (66 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (306 aa)
SSH1Slingshot homolog 1. (1062 aa)
ENSPTRP00000090995annotation not available (206 aa)
NCK1Cytoplasmic protein. (377 aa)
ENSPTRP00000091405annotation not available (334 aa)
TMOD2Tropomodulin 2 (Neuronal). (351 aa)
MYADMMyeloid-associated differentiation marker. (322 aa)
CARMIL2CARMIL2 isoform 2. (1436 aa)
SCIN-2SCIN isoform 2. (715 aa)
ENSPTRP00000092498Supervillin-like. (133 aa)
FCHSD2FCH and double SH3 domains 2. (764 aa)
CCL11C-C motif chemokine. (97 aa)
CDC42EP3CDC42 effector protein (Rho GTPase binding) 3. (254 aa)
BBS4Bardet-Biedl syndrome 4. (519 aa)
CAPZA1Capping actin protein of muscle Z-line subunit alpha 1. (325 aa)
TRIOBPTRIOBP isoform 1. (2139 aa)
PLEKHG2Pleckstrin homology domain containing, family G (With RhoGef domain) member 2. (1386 aa)
NPHS1NPHS1 isoform 1. (1241 aa)
ENSPTRP00000062048annotation not available (257 aa)
ENSPTRP00000062137annotation not available (195 aa)
PAK3Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...] (580 aa)
PFN3Profilin; Belongs to the profilin family. (137 aa)
FMN1FMN1 isoform 1. (1425 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
BAIAP2BAI1 associated protein 2. (553 aa)
SPTAN1SPTAN1 isoform 9. (2498 aa)
SNX9Sorting nexin. (596 aa)
ENSPTRP00000065871annotation not available (255 aa)
ENSPTRP00000066549annotation not available (154 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
ENSPTRP00000066855annotation not available (256 aa)
COTL1Coactosin like F-actin binding protein 1. (163 aa)
KANK3KN motif and ankyrin repeat domains 3. (840 aa)
ENSPTRP00000067474annotation not available (148 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
C15H15orf62Chromosome 15 C15orf62 homolog. (175 aa)
SPTBN5LOW QUALITY PROTEIN: spectrin beta chain, non-erythrocytic 5. (3705 aa)
TMSB4YThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
SPTBN4Spectrin beta, non-erythrocytic 4. (2565 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
CDC42EP2Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton; Belongs to the BORG/CEP family. (210 aa)
TWF1Twinfilin actin binding protein 1. (380 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1077 aa)
ENSPTRP00000073763annotation not available (92 aa)
ENSPTRP00000073520annotation not available (59 aa)
RDXRDX isoform 3. (609 aa)
CAPZBF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (301 aa)
CCL24-2C-C motif chemokine ligand 24. (119 aa)
SPTBN1Spectrin beta chain; Belongs to the spectrin family. (2366 aa)
ENSPTRP00000070693annotation not available (228 aa)
ENSPTRP00000070303annotation not available (117 aa)
MLST8MLST8 isoform 3. (327 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
ENSPTRP00000069497annotation not available (53 aa)
ENSPTRP00000067847annotation not available (809 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
TMSB4X-2Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (54 aa)
TMOD4TMOD4 isoform 2. (345 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
SPTA1SPTA1 isoform 1. (2419 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
LMOD1LMOD1 isoform 2. (600 aa)
SVILSVIL isoform 6. (2214 aa)
ESAMEndothelial cell adhesion molecule. (390 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (822 aa)
CAPZA3F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (299 aa)
NCKAP1LNCK associated protein 1 like. (1127 aa)
AVILAVIL isoform 2. (819 aa)
EVLEnah/Vasp-like; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (418 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
TMOD3Tropomodulin 3 (Ubiquitous). (352 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
PYCARDPYD and CARD domain containing. (195 aa)
ALOX15Arachidonate 15-lipoxygenase. (662 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
SSH2Slingshot protein phosphatase 2. (1450 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
FAM49AFAM49A isoform 1. (323 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
CAPGCapping actin protein, gelsolin like. (348 aa)
NCK2Cytoplasmic protein. (380 aa)
BIN1Bridging integrator 1. (597 aa)
NCKAP1Nck-associated protein 1. (1128 aa)
VIL1VIL1 isoform 1. (827 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
HCKTyrosine-protein kinase. (526 aa)
ARHGAP40Rho GTPase activating protein 40. (622 aa)
CDC42EP1CDC42 effector protein (Rho GTPase binding) 1. (391 aa)
BAIAP2L2BAIAP2L2 isoform 1. (518 aa)
VILLVILL isoform 1. (855 aa)
RHOARas homolog family member A. (193 aa)
TWF2T0016682 isoform 2. (349 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
LMOD3LMOD3 isoform 1. (560 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (484 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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