STRINGSTRING
SERPINB5 SERPINB5 PLAG1 PLAG1 ENSPTRP00000093582 ENSPTRP00000093582 LOC739615 LOC739615 ENSPTRP00000093022 ENSPTRP00000093022 PTEN PTEN FRS2 FRS2 MMP2 MMP2 PTCH1 PTCH1 LOC473133 LOC473133 FGF10 FGF10 RARG RARG FEM1B FEM1B NKX3-1 NKX3-1 BMP4-2 BMP4-2 GLI1 GLI1 UBE3A UBE3A ENSPTRP00000077262 ENSPTRP00000077262 AR AR SHH SHH EAF2 EAF2 ID4 ID4 ENSPTRP00000069792 ENSPTRP00000069792 HOXA10-2 HOXA10-2 HOXA10 HOXA10 PSAP PSAP CYP7B1 CYP7B1 HOXA13 HOXA13 FOXA1 FOXA1 ENSPTRP00000062206 ENSPTRP00000062206 CRIP1 CRIP1 PSAPL1 PSAPL1 SFRP1 SFRP1 RARA RARA WDR77 WDR77 FGFR2 FGFR2 FKBP4 FKBP4 CDKN1B CDKN1B BMP4 BMP4 CYP19A1 CYP19A1 SERPINF1 SERPINF1 HOXB13 HOXB13 NOG NOG SOX9 SOX9 STK11 STK11 HOXD13 HOXD13 TP63 TP63 PRLR PRLR ESR1 ESR1 HOXA11 HOXA11 TNC TNC NOTCH1 NOTCH1 CTNNB1 CTNNB1 HOXA13-2 HOXA13-2 ANXA1 ANXA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SERPINB5Serpin family B member 5; Belongs to the serpin family. (375 aa)
PLAG1PLAG1 zinc finger. (500 aa)
ENSPTRP00000093582annotation not available (368 aa)
LOC739615Peptidyl-prolyl cis-trans isomerase FKBP4 pseudogene. (398 aa)
ENSPTRP00000093022annotation not available (563 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
LOC473133Peptidyl-prolyl cis-trans isomerase FKBP4 pseudogene. (175 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
RARGRetinoic acid receptor, gamma. (456 aa)
FEM1BFEM1B isoform 1. (627 aa)
NKX3-1NKX3-1 isoform 1. (234 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
GLI1GLI family zinc finger 1. (1106 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (875 aa)
ENSPTRP00000077262annotation not available (314 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
EAF2ELL associated factor 2. (263 aa)
ID4Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein. (161 aa)
ENSPTRP00000069792annotation not available (651 aa)
HOXA10-2Homeobox A10. (410 aa)
HOXA10HOXA10 isoform 2. (410 aa)
PSAPProsaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (524 aa)
CYP7B1Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (506 aa)
HOXA13Homeobox A13. (388 aa)
FOXA1FOXA1 isoform 1. (471 aa)
ENSPTRP00000062206annotation not available (69 aa)
CRIP1Cysteine-rich protein 1 (Intestinal). (77 aa)
PSAPL1Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids. (521 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
RARARARA isoform 4. (624 aa)
WDR77Methylosome protein 50. (342 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
FKBP4Peptidylprolyl isomerase. (459 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B (P27, Kip1). (198 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
SERPINF1SERPINF1 isoform 1; Belongs to the serpin family. (418 aa)
HOXB13HOXB13 isoform 1. (284 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (307 aa)
HOXD13HOXD13 isoform 1. (344 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (622 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
HOXA11HOXA11 isoform 2. (313 aa)
TNCTNC isoform 1. (2201 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
HOXA13-2HOXA13 isoform 1. (388 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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