STRINGSTRING
ID1-2 ID1-2 PAX8 PAX8 CEBPB CEBPB CCND1 CCND1 F11R F11R CK820_G0014959 CK820_G0014959 RFX3 RFX3 LOC100615593 LOC100615593 BTG1 BTG1 PTCH1 PTCH1 TMEM100 TMEM100 STAT5B STAT5B ESRP1 ESRP1 EZH2-2 EZH2-2 MAFG MAFG STAT1 STAT1 PAX2 PAX2 SPRED3 SPRED3 OVOL2 OVOL2 BAD BAD NUMA1 NUMA1 ERRFI1 ERRFI1 KDF1 KDF1 MYCL MYCL IL20 IL20 H2AFY2 H2AFY2 NODAL NODAL VCL VCL YAP1 YAP1 GDF3 GDF3 FOXJ2 FOXJ2 CDKN1B CDKN1B WNT10B WNT10B ACVRL1 ACVRL1 KRT84 KRT84 CYP27B1 CYP27B1 SPRY2 SPRY2 BMP4 BMP4 SGPP1 SGPP1 SPRED1 SPRED1 MESP1 MESP1 CDH5 CDH5 ALOX15B ALOX15B TRIM16-2 TRIM16-2 FOXN1 FOXN1 MED1 MED1 KRT36 KRT36 ETV4 ETV4 VEZF1 VEZF1 SOX9 SOX9 FOXJ1 FOXJ1 KEAP1 KEAP1 SPRED3-2 SPRED3-2 ZFP36 ZFP36 CEACAM1 CEACAM1 OSR1 OSR1 XDH XDH SIX2 SIX2 REG3A REG3A IL1A IL1A IL1B IL1B FRZB FRZB ABCA12 ABCA12 BMP2 BMP2 PLCB1 PLCB1 JAG1 JAG1 NKX2-2 NKX2-2 ENSPTRP00000023194 ENSPTRP00000023194 MMP9 MMP9 NCOA3 NCOA3 BMP7 BMP7 LIF LIF TP63 TP63 ADD1 ADD1 PROM1 PROM1 NKX6-1 NKX6-1 DSPP DSPP KIAA1109 KIAA1109 PRLR PRLR FST FST H2AFY H2AFY BMP6 BMP6 HEY2 HEY2 AHI1 AHI1 DLL1 DLL1 SFRP4 SFRP4 SERPINE1 SERPINE1 CAV1 CAV1 PAX4 PAX4 SMO SMO IKBKB IKBKB GRHL2 GRHL2 COMMD5 COMMD5 ZDHHC21 ZDHHC21 AQP3 AQP3 NOTCH1 NOTCH1 HES5 HES5 PLAAT4 PLAAT4 CTNNB1 CTNNB1 WWTR1 WWTR1 APOLD1 APOLD1 NFE2L1 NFE2L1 GDNF GDNF SULT2B1 SULT2B1 MAFF MAFF REG3G REG3G FOXE3 FOXE3 NKX6-3 NKX6-3 ATOH1 ATOH1 LHX1 LHX1 S1PR3 S1PR3 SFN SFN NOTCH4 NOTCH4 ID1 ID1 WNT9B WNT9B ZFP36L1 ZFP36L1 TRIM16 TRIM16 KLF7 KLF7 GRHL1 GRHL1 ZEB1 ZEB1 LOC741150 LOC741150 ROCK2 ROCK2 HES1 HES1 PROC PROC GATA3 GATA3 TP73 TP73 FOXC1 FOXC1 PAX6 PAX6 SPRED2 SPRED2 TNFRSF1A TNFRSF1A ATOH8 ATOH8 SMO-2 SMO-2 FGF2 FGF2 ENSPTRP00000068511 ENSPTRP00000068511 ETV2 ETV2 GDF2 GDF2 TNF TNF PTCH2 PTCH2 SRSF6 SRSF6 ZBED2 ZBED2 CD109 CD109 ENSPTRP00000075771 ENSPTRP00000075771 WNT9B-2 WNT9B-2 EZH2 EZH2 ASCL1 ASCL1 AJAP1 AJAP1 LOC107968591 LOC107968591 HES5-2 HES5-2 BMP4-2 BMP4-2 CD24 CD24 SPRY1 SPRY1 CDKN2B CDKN2B FGF10 FGF10 VDR VDR KRAS KRAS TBX3 TBX3 ROCK1 ROCK1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ID1-2Inhibitor of DNA binding 1, HLH protein. (155 aa)
PAX8PAX8 isoform 1. (456 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
F11RF11R isoform 1. (322 aa)
CK820_G0014959KLF7 isoform 7. (258 aa)
RFX3RFX3 isoform 4. (761 aa)
LOC100615593Serine/arginine-rich splicing factor 6 pseudogene. (291 aa)
BTG1B-cell translocation gene 1, anti-proliferative. (171 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
TMEM100Transmembrane protein 100. (134 aa)
STAT5BSignal transducer and activator of transcription. (772 aa)
ESRP1Epithelial splicing regulatory protein 1. (681 aa)
EZH2-2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
MAFGV-maf musculoaponeurotic fibrosarcoma oncogene homolog G (Avian). (162 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
PAX2PAX2 isoform 1. (417 aa)
SPRED3Sprouty related EVH1 domain containing 3. (410 aa)
OVOL2Ovo like zinc finger 2. (275 aa)
BADBcl2-associated agonist of cell death. (168 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2111 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
MYCLMYCL isoform 2. (394 aa)
IL20IL20 isoform 1. (176 aa)
H2AFY2H2AFY2 isoform 1. (372 aa)
NODALNODAL isoform 2. (347 aa)
VCLVCL isoform 2. (1134 aa)
YAP1Yes-associated protein 1. (508 aa)
GDF3Growth differentiation factor 3. (364 aa)
FOXJ2FOXJ2 isoform 1. (573 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B (P27, Kip1). (198 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
KRT84KRT84 isoform 1; Belongs to the intermediate filament family. (600 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
SPRY2Sprouty homolog 2. (338 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (441 aa)
SPRED1Sprouty-related, EVH1 domain containing 1. (444 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (268 aa)
CDH5CDH5 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
ALOX15BArachidonate 15-lipoxygenase, type B. (676 aa)
TRIM16-2Tripartite motif containing 16. (560 aa)
FOXN1FOXN1 isoform 2. (648 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
KRT36KRT36 isoform 2; Belongs to the intermediate filament family. (467 aa)
ETV4ETV4 isoform 3. (484 aa)
VEZF1Vascular endothelial zinc finger 1. (518 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
FOXJ1FOXJ1 isoform 1. (421 aa)
KEAP1Kelch-like ECH-associated protein 1. (624 aa)
SPRED3-2Sprouty related EVH1 domain containing 3. (454 aa)
ZFP36Zinc finger protein 36, C3H type, homolog. (332 aa)
CEACAM1CEACAM1 isoform 3. (518 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
XDHXDH isoform 1. (1333 aa)
SIX2SIX homeobox 2. (291 aa)
REG3ARegenerating family member 3 alpha. (175 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
FRZBFrizzled-related protein. (325 aa)
ABCA12ATP binding cassette subfamily A member 12. (2595 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
NKX2-2NKX2-2 isoform 1. (273 aa)
ENSPTRP00000023194annotation not available (180 aa)
MMP9Matrix metallopeptidase 9. (699 aa)
NCOA3Nuclear receptor coactivator. (1426 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
LIFLeukemia inhibitory factor (Cholinergic differentiation factor). (202 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
ADD1ADD1 isoform 5. (768 aa)
PROM1PROM1 isoform 12. (865 aa)
NKX6-1NKX6-1 isoform 2. (367 aa)
DSPPDSPP isoform 1. (1292 aa)
KIAA1109KIAA1109 isoform 1. (5005 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (622 aa)
FSTFST isoform 1. (344 aa)
H2AFYH2AFY isoform 4. (372 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
AHI1Abelson helper integration site 1. (1196 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
SFRP4SFRP4 isoform 1. (368 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
PAX4PAX4 isoform 1. (351 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
COMMD5COMM domain containing 5. (224 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
AQP3Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
PLAAT4RARRES3 isoform 3. (164 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
APOLD1Apolipoprotein L domain containing 1. (279 aa)
NFE2L1Nuclear factor (Erythroid-derived 2)-like 1. (772 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
SULT2B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (365 aa)
MAFFV-maf musculoaponeurotic fibrosarcoma oncogene homolog F (Avian). (164 aa)
REG3GRegenerating islet-derived protein 3-gamma. (174 aa)
FOXE3FOXE3 isoform 1. (319 aa)
NKX6-3NKX6-3 isoform 1. (265 aa)
ATOH1Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). (356 aa)
LHX1LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (350 aa)
SFNSFN isoform 1; Belongs to the 14-3-3 family. (248 aa)
NOTCH4NOTCH4 isoform 3. (2006 aa)
ID1Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein. (155 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
TRIM16T0195358 isoform 1. (564 aa)
KLF7Kruppel-like factor 7 (Ubiquitous). (302 aa)
GRHL1Grainyhead like transcription factor 1. (619 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
LOC741150Vascular endothelial zinc finger 1 pseudogene. (442 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
PROCProtein C, inactivator of coagulation factors Va and VIIIa. (495 aa)
GATA3GATA binding protein 3. (444 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
FOXC1FOXC1 isoform 1. (550 aa)
PAX6PAX6 isoform 13. (436 aa)
SPRED2SPRED2 isoform 3. (432 aa)
TNFRSF1ATumor necrosis factor receptor superfamily, member 1A. (455 aa)
ATOH8Atonal bHLH transcription factor 8. (323 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
ENSPTRP00000068511annotation not available (353 aa)
ETV2ETV2 isoform 5. (370 aa)
GDF2GDF2 isoform 1. (429 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
PTCH2PTCH2 isoform 3. (1203 aa)
SRSF6Serine and arginine rich splicing factor 6. (344 aa)
ZBED2Zinc finger BED-type containing 2. (218 aa)
CD109CD109 isoform 3. (1446 aa)
ENSPTRP00000075771COMM domain-containing protein 5. (229 aa)
WNT9B-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
EZH2Enhancer of zeste homolog 2. (754 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
AJAP1Adherens junctions associated protein 1. (411 aa)
LOC107968591CD24 isoform 1. (80 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
CD24CD24 isoform 8. (129 aa)
SPRY1Sprouty homolog 1, antagonist of FGF signaling. (319 aa)
CDKN2BCyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4). (138 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
VDRVitamin D (1,25-dihydroxyvitamin D3) receptor. (477 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
TBX3T-box transcription factor 3. (743 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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