51 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CTNNB1	Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
	REG3G	Regenerating islet-derived protein 3-gamma. (174 aa)
	FOXE3	FOXE3 isoform 1. (319 aa)
	NKX6-3	NKX6-3 isoform 1. (265 aa)
	S1PR3	Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (350 aa)
	NOTCH4	NOTCH4 isoform 3. (2006 aa)
	ID1	Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein. (155 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1127 aa)
	GDF3	Growth differentiation factor 3. (364 aa)
	FOXJ2	FOXJ2 isoform 1. (573 aa)
	ACVRL1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
	SPRY2	Sprouty homolog 2. (338 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	SPRED1	Sprouty-related, EVH1 domain containing 1. (444 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	SPRED3-2	Sprouty related EVH1 domain containing 3. (454 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	XDH	XDH isoform 1. (1333 aa)
	SIX2	SIX homeobox 2. (291 aa)
	REG3A	Regenerating family member 3 alpha. (175 aa)
	IL1A	Interleukin-1; Belongs to the IL-1 family. (271 aa)
	FRZB	Frizzled-related protein. (325 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	ENSPTRP00000023194	annotation not available (180 aa)
	YAP1	Yes-associated protein 1. (508 aa)
	NODAL	NODAL isoform 2. (347 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	ID1-2	Inhibitor of DNA binding 1, HLH protein. (155 aa)
	CCND1	CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
	LOC100615593	Serine/arginine-rich splicing factor 6 pseudogene. (291 aa)
	EZH2-2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
	STAT1	Signal transducer and activator of transcription. (758 aa)
	OVOL2	Ovo like zinc finger 2. (275 aa)
	SPRED3	Sprouty related EVH1 domain containing 3. (410 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	SPRED2	SPRED2 isoform 3. (432 aa)
	SMO-2	Smoothened, frizzled class receptor. (786 aa)
	SRSF6	Serine and arginine rich splicing factor 6. (344 aa)
	EZH2	Enhancer of zeste homolog 2. (754 aa)
	HES5-2	Hes family bHLH transcription factor 5. (165 aa)
	SPRY1	Sprouty homolog 1, antagonist of FGF signaling. (319 aa)
	MMP9	Matrix metallopeptidase 9. (699 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	FST	FST isoform 1. (344 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	SMO	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	GRHL2	Grainyhead like transcription factor 2. (625 aa)
	NOTCH1	NOTCH1 isoform 1. (2555 aa)
	HES5	Hes family bHLH transcription factor 5. (165 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAV1	CTNNB1	ENSPTRP00000033587	ENSPTRP00000044466	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.558
CAV1	SPRED1	ENSPTRP00000033587	ENSPTRP00000011790	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Sprouty-related, EVH1 domain containing 1.	0.787
CCND1	CTNNB1	ENSPTRP00000086048	ENSPTRP00000044466	CCND1 isoform 1; Belongs to the cyclin family.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.777
CCND1	EZH2	ENSPTRP00000086048	ENSPTRP00000077344	CCND1 isoform 1; Belongs to the cyclin family.	Enhancer of zeste homolog 2.	0.482
CCND1	EZH2-2	ENSPTRP00000086048	ENSPTRP00000090461	CCND1 isoform 1; Belongs to the cyclin family.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.484
CCND1	JAG1	ENSPTRP00000086048	ENSPTRP00000022729	CCND1 isoform 1; Belongs to the cyclin family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.627
CCND1	KRAS	ENSPTRP00000086048	ENSPTRP00000084588	CCND1 isoform 1; Belongs to the cyclin family.	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.	0.686
CCND1	MMP9	ENSPTRP00000086048	ENSPTRP00000023334	CCND1 isoform 1; Belongs to the cyclin family.	Matrix metallopeptidase 9.	0.656
CCND1	NOTCH1	ENSPTRP00000086048	ENSPTRP00000036924	CCND1 isoform 1; Belongs to the cyclin family.	NOTCH1 isoform 1.	0.760
CCND1	SMO	ENSPTRP00000086048	ENSPTRP00000033707	CCND1 isoform 1; Belongs to the cyclin family.	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.414
CCND1	SOX9	ENSPTRP00000086048	ENSPTRP00000016293	CCND1 isoform 1; Belongs to the cyclin family.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.403
CCND1	STAT1	ENSPTRP00000086048	ENSPTRP00000090934	CCND1 isoform 1; Belongs to the cyclin family.	Signal transducer and activator of transcription.	0.686
CCND1	YAP1	ENSPTRP00000086048	ENSPTRP00000007247	CCND1 isoform 1; Belongs to the cyclin family.	Yes-associated protein 1.	0.438
CCND1	ZEB1	ENSPTRP00000086048	ENSPTRP00000062768	CCND1 isoform 1; Belongs to the cyclin family.	Zinc finger E-box binding homeobox 1.	0.590
CTNNB1	CAV1	ENSPTRP00000044466	ENSPTRP00000033587	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.558
CTNNB1	CCND1	ENSPTRP00000044466	ENSPTRP00000086048	Catenin (Cadherin-associated protein), beta 1, 88kDa.	CCND1 isoform 1; Belongs to the cyclin family.	0.777
CTNNB1	DLL1	ENSPTRP00000044466	ENSPTRP00000032142	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.535
CTNNB1	EZH2	ENSPTRP00000044466	ENSPTRP00000077344	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Enhancer of zeste homolog 2.	0.787
CTNNB1	EZH2-2	ENSPTRP00000044466	ENSPTRP00000090461	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.787
CTNNB1	FGF10	ENSPTRP00000044466	ENSPTRP00000083399	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.512