STRINGSTRING
TBR1 TBR1 RERE RERE POU4F1 POU4F1 HSPA5 HSPA5 LMX1A LMX1A KIF14 KIF14 PLXNA2 PLXNA2 EGR2 EGR2 KNDC1 KNDC1 KCNC1 KCNC1 FZD4 FZD4 CD3E CD3E WNT1 WNT1 FAIM2 FAIM2 CEP290 CEP290 LHX5 LHX5 KDM2B KDM2B PSEN1 PSEN1 CKB CKB TTBK2 TTBK2 ALDH1A2 ALDH1A2 HERC1 HERC1 IGF1R IGF1R ABAT ABAT CBLN1 CBLN1 RPGRIP1L RPGRIP1L TP53 TP53 SEZ6 SEZ6 HAP1 HAP1 KAT2A KAT2A NAGLU NAGLU HOXB1 HOXB1 HOXB2 HOXB2 NOG NOG PTPRS PTPRS ATF5 ATF5 OTX1 OTX1 SEMA4C SEMA4C TTC21B TTC21B SERPINE2 SERPINE2 GBX2 GBX2 ATRN ATRN NANOS1 NANOS1 BMP7 BMP7 CBS CBS TTLL1 TTLL1 ARL13B ARL13B PHOX2B PHOX2B GSX2 GSX2 HNRNPD HNRNPD SEC24B SEC24B EGF EGF SMAD1 SMAD1 CPLANE1 CPLANE1 SLC25A46 SLC25A46 AIF1 AIF1 LRRC1 LRRC1 BMP5 BMP5 PDSS2 PDSS2 AHI1 AHI1 DIXDC1 DIXDC1 DLL1 DLL1 HOXA2 HOXA2 OGDH OGDH SMO SMO DLC1 DLC1 KLHL4 KLHL4 LDB1 LDB1 GLI2 GLI2 NLGN4X NLGN4X SPTBN2 SPTBN2 ATIC ATIC GDF10 GDF10 COQ8B COQ8B MTPN MTPN CTNNB1 CTNNB1 GART GART NEUROD2 NEUROD2 CRKL CRKL PHOX2A PHOX2A CEND1 CEND1 EN1 EN1 PROX1 PROX1 MAFB MAFB DAB1 DAB1 EPHB2 EPHB2 CDK5R1 CDK5R1 ATP1B2 ATP1B2 AARS1 AARS1 GATA2 GATA2 LHX1 LHX1 EPHB1 EPHB1 NFIB NFIB NEUROG3 NEUROG3 PTPN11 PTPN11 CK820_G0012168 CK820_G0012168 SCRIB SCRIB CLP1 CLP1 HOXB3 HOXB3 LOC100609513 LOC100609513 LPAR1 LPAR1 CK820_G0054728 CK820_G0054728 ATF2 ATF2 HES1 HES1 ATP7A ATP7A WNT7A WNT7A FOXC1 FOXC1 KLHL5 KLHL5 MYO16 MYO16 ENSPTRP00000067174 ENSPTRP00000067174 SMO-2 SMO-2 WHRN WHRN SSTR1 SSTR1 AGTPBP1 AGTPBP1 SSTR3 SSTR3 SCN5A SCN5A ITGB1 ITGB1 ENSPTRP00000070307 ENSPTRP00000070307 ENSPTRP00000070863 ENSPTRP00000070863 ENSPTRP00000071105 ENSPTRP00000071105 EN2 EN2 WLS WLS ABL1 ABL1 NRXN1 NRXN1 EN2-2 EN2-2 PTPN11-2 PTPN11-2 ENSPTRP00000074763 ENSPTRP00000074763 CNTN1 CNTN1 SHH SHH CTNNA2 CTNNA2 UQCRQ UQCRQ ENSPTRP00000077189 ENSPTRP00000077189 ENSPTRP00000077211 ENSPTRP00000077211 EZH2 EZH2 ASCL1 ASCL1 ENSPTRP00000078003 ENSPTRP00000078003 GLI1 GLI1 PSMG1 PSMG1 ARCN1 ARCN1 LOC107974864 LOC107974864 LEF1 LEF1 ENSPTRP00000080117 ENSPTRP00000080117 CDK5 CDK5 SEZ6L2 SEZ6L2 ENSPTRP00000081136 ENSPTRP00000081136 FAM205A FAM205A MECP2 MECP2 SSTR2 SSTR2 GRID2 GRID2 GART-2 GART-2 PTF1A PTF1A CRK CRK NHLH2 NHLH2 MDK MDK ENSPTRP00000085189 ENSPTRP00000085189 B4GALT2 B4GALT2 ENSPTRP00000086358 ENSPTRP00000086358 SDF4 SDF4 RORA RORA ZNF365 ZNF365 PTBP2 PTBP2 CDK5R2 CDK5R2 KLHL1 KLHL1 OPHN1 OPHN1 NAV2 NAV2 ENSPTRP00000089450 ENSPTRP00000089450 BCL2 BCL2 EZH2-2 EZH2-2 TRNP1 TRNP1 ENSPTRP00000092364 ENSPTRP00000092364 ENSPTRP00000092702 ENSPTRP00000092702 SCRIB-2 SCRIB-2 NCSTN NCSTN GNPAT GNPAT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBR1T-box brain transcription factor 1. (682 aa)
REREArginine-glutamic acid dipeptide (RE) repeats. (1566 aa)
POU4F1POU domain protein. (350 aa)
HSPA5Heat shock 70kDa protein 5 (Glucose-regulated protein, 78kDa); Belongs to the heat shock protein 70 family. (654 aa)
LMX1ALIM homeobox transcription factor 1 alpha. (382 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1648 aa)
PLXNA2PLXNA2 isoform 1. (1909 aa)
EGR2Early growth response 2. (476 aa)
KNDC1KNDC1 isoform 1. (1672 aa)
KCNC1Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family. (585 aa)
FZD4FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
CD3ECD3E isoform 2. (207 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
FAIM2FAIM2 isoform 2; Belongs to the BI1 family. (316 aa)
CEP290CEP290 isoform 5. (2454 aa)
LHX5LHX5 isoform 2. (402 aa)
KDM2BLysine (K)-specific demethylase 2B. (1336 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
CKBCreatine kinase, brain; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
TTBK2TTBK2 isoform 2; Belongs to the intermediate filament family. (1649 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
HERC1Hect (Homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1. (4861 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (515 aa)
CBLN1Cerebellin 1 precursor. (193 aa)
RPGRIP1LRPGRIP1L isoform 4. (1269 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
SEZ6Seizure related 6 homolog. (994 aa)
HAP1HAP1 isoform 2. (667 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (743 aa)
HOXB1Homeobox protein Hox-B1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures (By similarity); Belongs to the Antp homeobox family. Labial subfamily. (301 aa)
HOXB2HOXB2 isoform 1. (356 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1948 aa)
ATF5ATF5 isoform 1. (282 aa)
OTX1Orthodenticle homeobox 1. (354 aa)
SEMA4CSEMA4C isoform 2; Belongs to the semaphorin family. (833 aa)
TTC21BTetratricopeptide repeat domain 21B. (1316 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
ATRNATRN isoform 1. (1429 aa)
NANOS1Nanos C2HC-type zinc finger 1; Belongs to the nanos family. (290 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (551 aa)
TTLL1Tubulin tyrosine ligase-like family, member 1. (404 aa)
ARL13BADP ribosylation factor like GTPase 13B. (428 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
GSX2GSX2 isoform 2. (304 aa)
HNRNPDHNRNPD isoform 1. (356 aa)
SEC24BSEC24B isoform 1. (1286 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
SMAD1Mothers against decapentaplegic homolog. (469 aa)
CPLANE1Ciliogenesis and planar polarity effector 1. (3197 aa)
SLC25A46Solute carrier family 25, member 46; Belongs to the mitochondrial carrier (TC 2.A.29) family. (418 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
PDSS2Prenyl (Decaprenyl) diphosphate synthase, subunit 2; Belongs to the FPP/GGPP synthase family. (399 aa)
AHI1Abelson helper integration site 1. (1196 aa)
DIXDC1DIX domain containing 1. (683 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
HOXA2HOXA2 isoform 1. (376 aa)
OGDHOxoglutarate dehydrogenase. (1038 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
DLC1DLC1 Rho GTPase activating protein. (1528 aa)
KLHL4Kelch like family member 4. (718 aa)
LDB1LIM domain binding 1. (411 aa)
GLI2GLI family zinc finger 2. (1587 aa)
NLGN4XNeuroligin 4 X-linked. (817 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2390 aa)
ATIC5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (592 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
COQ8BAarF domain containing kinase 4. (544 aa)
MTPNMTPN isoform 1. (118 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
GARTTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa)
NEUROD2Neurogenic differentiation factor. (382 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
PHOX2APaired like homeobox 2A. (284 aa)
CEND1Cell cycle exit and neuronal differentiation 1. (149 aa)
EN1Homeobox protein engrailed-like. (396 aa)
PROX1Prospero homeobox 1. (737 aa)
MAFBV-maf musculoaponeurotic fibrosarcoma oncogene homolog B (Avian). (323 aa)
DAB1DAB adaptor protein 1. (588 aa)
EPHB2EPH receptor B2. (1055 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
AARS1Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
GATA2GATA binding protein 2. (480 aa)
LHX1LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
EPHB1EPH receptor B1. (984 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
NEUROG3NEUROG3 isoform 1. (214 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
SCRIBSCRIB isoform 8. (959 aa)
CLP1Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (425 aa)
HOXB3HOXB3 isoform 13. (431 aa)
LOC10060951378 kDa glucose-regulated protein pseudogene. (617 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CK820_G0054728MECP2 isoform 14. (493 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
ATP7AATPase, Cu++ transporting, alpha polypeptide. (1500 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
FOXC1FOXC1 isoform 1. (550 aa)
KLHL5Kelch like family member 5. (757 aa)
MYO16MYO16 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1903 aa)
ENSPTRP00000067174annotation not available (502 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
WHRNWHRN isoform 2. (907 aa)
SSTR1Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (391 aa)
AGTPBP1ATP/GTP binding protein 1. (1290 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (418 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ENSPTRP00000070307annotation not available (237 aa)
ENSPTRP00000070863annotation not available (261 aa)
ENSPTRP00000071105annotation not available (376 aa)
EN2Engrailed homeobox 2. (338 aa)
WLSWnt ligand secretion mediator. (543 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
NRXN1NRXN1 isoform 9. (1547 aa)
EN2-2Homeobox protein engrailed-like. (336 aa)
PTPN11-2Protein tyrosine phosphatase non-receptor type 11. (579 aa)
ENSPTRP00000074763annotation not available (520 aa)
CNTN1CNTN1 isoform 1. (1028 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
CTNNA2CTNNA2 isoform 11. (953 aa)
UQCRQUbiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa. (82 aa)
ENSPTRP00000077189annotation not available (276 aa)
ENSPTRP00000077211annotation not available (269 aa)
EZH2Enhancer of zeste homolog 2. (754 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
ENSPTRP00000078003annotation not available (847 aa)
GLI1GLI family zinc finger 1. (1106 aa)
PSMG1Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2. (288 aa)
ARCN1Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (552 aa)
LOC107974864Cytochrome b-c1 complex subunit 8. (82 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
ENSPTRP00000080117annotation not available (567 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
SEZ6L2Seizure related 6 homolog-like 2. (923 aa)
ENSPTRP00000081136LOW QUALITY PROTEIN: uncharacterized protein LOC100614654. (148 aa)
FAM205AFAM205A isoform 1. (1298 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
SSTR2Somatostatin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (1007 aa)
GART-2annotation not available (1010 aa)
PTF1APancreas associated transcription factor 1a. (328 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
NHLH2Nescient helix-loop-helix 2. (135 aa)
MDKMidkine (Neurite growth-promoting factor 2). (143 aa)
ENSPTRP00000085189annotation not available (1896 aa)
B4GALT2B4GALT2 isoform 6. (398 aa)
ENSPTRP00000086358annotation not available (72 aa)
SDF4Stromal cell derived factor 4. (407 aa)
RORARAR-related orphan receptor A. (555 aa)
ZNF365Zinc finger protein 365. (407 aa)
PTBP2Polypyrimidine tract binding protein 2. (543 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (367 aa)
KLHL1Kelch like family member 1. (748 aa)
OPHN1Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre- synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). (810 aa)
NAV2Neuron navigator 2. (2488 aa)
ENSPTRP00000089450annotation not available (303 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
EZH2-2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
TRNP1TMF1-regulated nuclear protein 1. (227 aa)
ENSPTRP00000092364annotation not available (574 aa)
ENSPTRP00000092702annotation not available (482 aa)
SCRIB-2Scribbled homolog. (1662 aa)
NCSTNNCSTN isoform 1. (721 aa)
GNPATDihydroxyacetone phosphate acyltransferase. (691 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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