8 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CEP290	CEP290 isoform 5. (2454 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	HESX1	Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity). (185 aa)
	TCAP	TCAP isoform 1. (167 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGF10	FGF8	ENSPTRP00000083399	ENSPTRP00000075677	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.549
FGF10	FGFR2	ENSPTRP00000083399	ENSPTRP00000005308	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.996
FGF10	SOX9	ENSPTRP00000083399	ENSPTRP00000016293	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.536
FGF8	FGF10	ENSPTRP00000075677	ENSPTRP00000083399	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.549
FGF8	FGFR2	ENSPTRP00000075677	ENSPTRP00000005308	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.969
FGF8	SOX9	ENSPTRP00000075677	ENSPTRP00000016293	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.484
FGFR2	FGF10	ENSPTRP00000005308	ENSPTRP00000083399	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.996
FGFR2	FGF8	ENSPTRP00000005308	ENSPTRP00000075677	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.969
SOX9	FGF10	ENSPTRP00000016293	ENSPTRP00000083399	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.536
SOX9	FGF8	ENSPTRP00000016293	ENSPTRP00000075677	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.484