Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKAP8 | AKAP8L | ENSPTRP00000083023 | ENSPTRP00000083207 | A kinase (PRKA) anchor protein 8; Belongs to the AKAP95 family. | A kinase (PRKA) anchor protein 8-like; Belongs to the AKAP95 family. | 0.480 |
| AKAP8L | AKAP8 | ENSPTRP00000083207 | ENSPTRP00000083023 | A kinase (PRKA) anchor protein 8-like; Belongs to the AKAP95 family. | A kinase (PRKA) anchor protein 8; Belongs to the AKAP95 family. | 0.480 |
| APLNR | ARRB1 | ENSPTRP00000006308 | ENSPTRP00000043134 | APLNR isoform 1; Belongs to the G-protein coupled receptor 1 family. | ARRB1 isoform 1. | 0.503 |
| ARID5A | SMARCB1 | ENSPTRP00000020966 | ENSPTRP00000040536 | AT rich interactive domain 5A (MRF1-like). | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. | 0.535 |
| ARRB1 | APLNR | ENSPTRP00000043134 | ENSPTRP00000006308 | ARRB1 isoform 1. | APLNR isoform 1; Belongs to the G-protein coupled receptor 1 family. | 0.503 |
| ARRB1 | CTNNB1 | ENSPTRP00000043134 | ENSPTRP00000044466 | ARRB1 isoform 1. | Catenin (Cadherin-associated protein), beta 1, 88kDa. | 0.557 |
| ARRB1 | GCG | ENSPTRP00000043134 | ENSPTRP00000049083 | ARRB1 isoform 1. | GCG isoform 1. | 0.486 |
| ARRB1 | MAPK3 | ENSPTRP00000043134 | ENSPTRP00000053615 | ARRB1 isoform 1. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.978 |
| ARRB1 | RTF1 | ENSPTRP00000043134 | ENSPTRP00000011849 | ARRB1 isoform 1. | Rtf1, Paf1/RNA polymerase II complex component, homolog. | 0.447 |
| ARRB1 | SNCA | ENSPTRP00000043134 | ENSPTRP00000090843 | ARRB1 isoform 1. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.469 |
| ATG5 | IL1B | ENSPTRP00000031526 | ENSPTRP00000021191 | Autophagy protein 5; Involved in autophagic vesicle formation. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.461 |
| ATG5 | MAPK8 | ENSPTRP00000031526 | ENSPTRP00000040692 | Autophagy protein 5; Involved in autophagic vesicle formation. | Mitogen-activated protein kinase. | 0.413 |
| ATG5 | PINK1 | ENSPTRP00000031526 | ENSPTRP00000000500 | Autophagy protein 5; Involved in autophagic vesicle formation. | PTEN induced putative kinase 1. | 0.576 |
| ATG5 | SIRT1 | ENSPTRP00000031526 | ENSPTRP00000004394 | Autophagy protein 5; Involved in autophagic vesicle formation. | SIRT1 isoform 2. | 0.690 |
| ATG5 | SIRT1-2 | ENSPTRP00000031526 | ENSPTRP00000093057 | Autophagy protein 5; Involved in autophagic vesicle formation. | Sirtuin 1. | 0.690 |
| ATG5 | SNCA | ENSPTRP00000031526 | ENSPTRP00000090843 | Autophagy protein 5; Involved in autophagic vesicle formation. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.426 |
| ATG5 | TP53 | ENSPTRP00000031526 | ENSPTRP00000014836 | Autophagy protein 5; Involved in autophagic vesicle formation. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.575 |
| ATM | ATRX | ENSPTRP00000054216 | ENSPTRP00000087577 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Transcriptional regulator ATRX; Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase a [...] | 0.736 |
| ATM | BRCA1 | ENSPTRP00000054216 | ENSPTRP00000070120 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.999 |
| ATM | CDK9 | ENSPTRP00000054216 | ENSPTRP00000036573 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily. | 0.403 |
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